Results 21 to 30 of about 352,933 (230)

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Fluids and Barriers of the CNS, 2019
Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang, Joel S. Pachter   +5 more
doaj   +1 more source

Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis

Neurobiology of Disease, 2017
Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is a neuroinflammatory, demyelinating disease widely recognized as an animal model of multiple ...
Bandana Shrestha, Xi Jiang, Shujun Ge, Debayon Paul, Peter Chianchiano, Joel S. Pachter   +5 more
doaj   +1 more source

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Frontiers in Cell and Developmental Biology, 2023
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu, Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Lu Chen, Wanlin Ye, Wanlin Ye, Yi Kang, Yi Kang, Guo Chen, Guo Chen, Tao Zhu, Tao Zhu   +13 more
doaj   +1 more source

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source

MOESM1 of Kv1.3 channel blocker (ImKTx88) maintains bloodâ brain barrier in experimental autoimmune encephalomyelitis

, 2017
Additional file 1: Tables S1. ImKTx88 reduces clinical signs in EAE rats.
Huang, Jie, Han, Song, Sun, Qi, Yipeng Zhao, Junchen Liu, Xiaolu Yuan, Wenqian Mao, Biwen Peng, Wanhong Liu, Yin, Jun, Xiaohua He   +10 more
openaire   +1 more source

Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

MOESM1 of Accelerated differentiation of human induced pluripotent stem cells to bloodâ brain barrier endothelial cells

, 2017
Additional file 1. Additional characterization of iPSC-derived BMECsâ primary antibody and secondary antibody information, including recognized antigen, clone, vendor, and dilution, are listed in Tables S1 and S2, respectively. Immunocytochemical analysis of astrocytes and pericytes used in co-culture experiment are shown in Figure S1.
Hollmann, Emma, Bailey, Amanda, Potharazu, Archit, Neely, M., Bowman, Aaron, Lippmann, Ethan   +5 more
openaire   +1 more source

MOESM1 of The role of mutations associated with familial neurodegenerative disorders on bloodâ brain barrier function in an iPSC model

, 2019
Additional file 1: Figure S1. Phase images of differentiation of iPSCs. Figure S2. Western blots. Figure S3. Expression of individual proteins and genes across all disease lines. Figure S4. Protein and gene expression by disease. Figure S5. Gene expression normalized to WT2 and iPS12 lines. Figure S6. Additional stains: ZO-1. Figure S7.
Katt, Moriah, Mayo, Lakyn, Ellis, Shannon, Mahairaki, Vasiliki, Rothstein, Jeffrey, Cheng, Linzhao, Searson, Peter   +6 more
openaire   +1 more source

MOESM1 of Human ES-derived MSCs correct TNF-Îą-mediated alterations in a bloodâ brain barrier model

, 2019
Additional file 1: Table S1. List qRT-PCR human primer sequences.
Ge, Shujun, Jiang, Xi, Paul, Debayon, Song, Li, Wang, Xiaofang, Pachter, Joel   +5 more
openaire   +1 more source

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source