Results 21 to 30 of about 681,701 (257)

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Janssens, Yorick, Maes, Alex, Sathekge, Mike, Tack, Liesa, Van De Wiele, Christophe, Wynendaele, Evelien   +7 more
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Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis

Neurobiology of Disease, 2017
Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is a neuroinflammatory, demyelinating disease widely recognized as an animal model of multiple ...
Bandana Shrestha, Xi Jiang, Shujun Ge, Debayon Paul, Peter Chianchiano, Joel S. Pachter   +5 more
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Translocating the blood-brain barrier using electrostatics [PDF]

, 2012
Copyright © 2012 Ribeiro,Domingues, Freire,Santos and Castanho. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the ...
Castanho, Miguel A. R. B., Domingues, Marco M., Freire, João M., Ribeiro, Marta M. B., Santos, Nuno C.   +4 more
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Research progress on perioperative blood-brain barrier damage and its potential mechanism

Frontiers in Cell and Developmental Biology, 2023
The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu, Yong Qiu, Chunheng Mo, Shiyu Xu, Lu Chen, Lu Chen, Wanlin Ye, Wanlin Ye, Yi Kang, Yi Kang, Guo Chen, Guo Chen, Tao Zhu, Tao Zhu   +13 more
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Regulation of brain endothelial barrier function by microRNAs in health and neuroinflammation [PDF]

, 2016
Brain endothelial cells constitute the major cellular element of the highly specialized blood–brain barrier (BBB) and thereby contribute to CNS homeostasis by restricting entry of circulating leukocytes and blood-borne molecules into the CNS.
Arie Reijerkerk, Cheng W., Helga E. Vries, Heusschen R., Ignacio Andres Romero, Miguel Alejandro Lopez‐Ramirez, Waig S.   +6 more
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Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Fluids and Barriers of the CNS, 2018
Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez, Allison M. Andrews, Debayon Paul, Joel S. Pachter   +3 more
doaj   +1 more source

Real-time monitoring of human blood-brain barrier disruption [PDF]

, 2017
Chemotherapy aided by opening of the blood-brain barrier with intra-arterial infusion of hyperosmolar mannitol improves the outcome in primary central nervous system lymphoma.
Alahuhta, Seppo, Isokangas, Matti, Keinanen, Tuija, Kiviniemi, Vesa, Korhonen, Vesa, Kortelainen, Jukka, Kuittinen, Outi, Myllyla, Teemu, Nikkinen, Juha, Rytky, Seppo, Siniluoto, Topi, Sonkajarvi, Eila, Tervonen, Osmo, Tuovinen, Timo, Turpeenniemi-Hujanen, Taina, Voipio, Juha   +15 more
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Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion

Journal of Pharmacy & Pharmaceutical Sciences, 2013
Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj   +1 more source

Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective

Frontiers in Pharmacology, 2019
Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie, Luca Cucullo, Luca Cucullo   +2 more
doaj   +1 more source

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction [PDF]

, 2016
Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and ...
Abraham, Ahdieh, Ahles, Ahles, Al-Dasooqi, Al-Dasooqi, Al-Dasooqi, Alkam, Argaw, Argaw, Asahi, Ashburner, Bauer, Bercik, Blanco, Bona, Bourke, Boussios, Bowen, Bower, Brown, Brown, Brown, Caliceti, Capuron, Chen, Cheng, Chidlow, Chodobski, Collado-Hidalgo, Corps, Cummins, D'Alessio, Dantzer, Deprez, Deprez, Dietrich, Dietrich, Dietrich, Ferguson, Frank, Gahtan, Galvez, Gangloff, Gatti, Genschaft, Ginos, Goehler, Guo, Han, Henriksen, Higashida, Hjermstad, Holden, Holmes, Horky, in't Veld, Inagaki, Janelsins, Jenkins, Jenkins, Jiao, Jickling, Komaki, Krabbe, Krabbe, Laye, Lepage, Li, Lischper, Liu, Logan, Logan, McDonald, McDonald, Meyers, Minter, Mustian, Natah, Nokia, Nyuyki, Pan, Pan, Papadakis, Patel, Proescholdt, Quan, Riazi, Rochfort, Rodriguez, Roque, Schreibelt, Seigers, Seigers, Sharma, Sharma, Sharma, Simo, Sodeck, Sonis, Sparkman, Stringer, Stringer, Tannock, Trask, Vardy, Vermeer, Villena, Vink, Vries, Wang, Wardill, Wardill, Wardill, Wardill, Wardill, Wardill, Wardill, Wong, Wu, Zonis   +120 more
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