Results 21 to 30 of about 352,834 (131)

Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V

Molecules, 2015
α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch, Jorick Vanbeselaere, Clément P. Delannoy, Aurore Drolez, Caroline Mysiorek, Yann Guérardel, Philippe Delannoy, Sylvain Julien   +7 more
doaj   +1 more source

Additional file 1: of Mesenchymal stem cells decrease bloodâ brain barrier permeability in rats with severe acute pancreatitis

, 2019
Table of primers. (DOCX 15 kb)
Lin, Ronggui, Li, Ming, Luo, Meiqin, Teng, Tianhong, Pan, Yu, Huang, Heguang   +5 more
openaire   +1 more source

Cannabinoids, Blood–Brain Barrier, and Brain Disposition

Pharmaceutics, 2020
Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai, Luigi Cardia, Emanuela Elisa Sorbara, Michele Navarra, Sebastiano Gangemi, Gioacchino Calapai, Carmen Mannucci   +6 more
doaj   +1 more source

Additional file 1: of CXCL5 signaling is a shared pathway of neuroinflammation and bloodâ brain barrier injury contributing to white matter injury in the immature brain

, 2016
Supplementary methods. The measurement of cerebral ventricular size and quantification methods for gray matter injury and immunohistochemistry are described in detail here. (DOC 5563 kb)
Lin-Yu Wang, Tu, Yi-Fang, Yung-Chieh Lin, Chao-Ching Huang   +3 more
openaire   +1 more source

MOESM1 of Modeling and rescue of defective bloodâ brain barrier function of induced brain microvascular endothelial cells from childhood cerebral adrenoleukodystrophy patients

, 2018
Additional file 1: Table S1. Information on induced pluripotent stem cell (iPSC) lines used in study. Table S2. Primary antibodies used for immunocytochemistry. Table S3. Secondary antibodies used for immunocytochemistry. Table S4. Primers used for RT-PCR. Figure S1. Polymer characterization data. Figure S2. Representative immunocytochemistry images of
Lee, Catherine, Seo, Hannah, Armien, Anibal, Bates, Frank, Tolar, Jakub, Azarin, Samira   +5 more
openaire   +1 more source

High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro

Journal of Neuroinflammation, 2023
Introduction The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML).
Sasha Soldati, Alexander Bär, Mykhailo Vladymyrov, Dale Glavin, James L. McGrath, Fabien Gosselet, Hideaki Nishihara, Susan Goelz, Britta Engelhardt   +8 more
doaj   +1 more source

Dissecting gene expression at the blood-brain barrier

Frontiers in Neuroscience, 2014
The availability of genome-wide expression data for the blood-brain barrier is an invaluable resource that has recently enabled the discovery of several genes and pathways involved in the development and maintenance of the blood-brain barrier ...
Melanie A Huntley, Nga eBien-Ly, Richard eDaneman, Ryan J Watts   +3 more
doaj   +1 more source

Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Molecular Medicine
Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects.
Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Mazurek, Fabien Gosselet   +11 more
doaj   +1 more source

Organoid-engineered neurovascular units for drug discovery and neurodegeneration research [PDF]

BioImpacts
The highly selective permeability of the human blood-brain barrier presents a major obstacle to neurological disease modeling. Established 2D cell cultures and animal models are unable to accurately reproduce the physiological and molecular features of ...
Ailar Nakhlband
doaj   +1 more source

How anti-brain antibodies access the bran and alter behavior and cognition

Journal of Affective Disorders Reports, 2023
Antibodies can target brain antigens but are not harmful to the host unless they enter brain parenchyma. An adult human or mouse has a blood brain barrier that excludes immunoglobulin from entering brain parenchyma.
Betty Diamond, MD
doaj   +1 more source