Results 1 to 10 of about 304,379 (119)

The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. [PDF]

PLoS ONE, 2010
The blood-brain barrier (BBB) maintains brain homeostasis and limits the entry of toxins and pathogens into the brain. Despite its importance, little is known about the molecular mechanisms regulating the development and function of this crucial barrier.
Richard Daneman, Lu Zhou, Dritan Agalliu, John D Cahoy, Amit Kaushal, Ben A Barres   +5 more
doaj   +3 more sources

Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1

Cells, 2022
The transport of low-density lipoprotein (LDL) through the endothelium is a key step in the development of atherosclerosis, but it is notorious that phenotypic differences exist between endothelial cells originating from different vascular beds ...
Sofia Kakava, Eveline Schlumpf, Grigorios Panteloglou, Flavia Tellenbach, Arnold von Eckardstein, Jerome Robert   +5 more
doaj   +1 more source

Integrin binding peptides facilitate growth and interconnected vascular-like network formation of rat primary cortical vascular endothelial cells in vitro

Neural Regeneration Research, 2023
Neovascularization and angiogenesis in the brain are important physiological processes for normal brain development and repair/regeneration following insults.
Ram Kuwar, Xuejun Wen, Ning Zhang, Dong Sun   +3 more
doaj   +1 more source

Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells: Current Controversies

Frontiers in Physiology, 2021
Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis and regulation of interactions between the brain and immune system ...
Tyler M. Lu, Tyler M. Lu, José Gabriel Barcia Durán, Sean Houghton, Shahin Rafii, David Redmond, Raphaël Lis, Raphaël Lis   +7 more
doaj   +1 more source

Porphyromonas gingivalis Induces Proinflammatory Cytokine Expression Leading to Apoptotic Death through the Oxidative Stress/NF-κB Pathway in Brain Endothelial Cells

Cells, 2021
Porphyromonas gingivalis, a periodontal pathogen, has been proposed to cause blood vessel injury leading to cerebrovascular diseases such as stroke. Brain endothelial cells compose the blood-brain barrier that protects homeostasis of the central nervous ...
Vichuda Charoensaensuk, Yen-Chou Chen, Yun-Ho Lin, Keng-Liang Ou, Liang-Yo Yang, Dah-Yuu Lu   +5 more
doaj   +1 more source

Mechanisms of Candida albicans trafficking to the brain. [PDF]

PLoS Pathogens, 2011
During hematogenously disseminated disease, Candida albicans infects most organs, including the brain. We discovered that a C. albicans vps51Δ/Δ mutant had significantly increased tropism for the brain in the mouse model of disseminated disease.
Yaoping Liu, Rahul Mittal, Norma V Solis, Nemani V Prasadarao, Scott G Filler   +4 more
doaj   +1 more source

Established, New and Emerging Concepts in Brain Vascular Development

Frontiers in Physiology, 2021
In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta, Kevin R. Rarick, Ramani Ramchandran   +2 more
doaj   +1 more source

Thinking outside the black box: are the brain endothelial cells the new main target in Alzheimer’s disease?

Neural Regeneration Research, 2023
The blood-brain barrier is the interface through which the brain interacts with the milieu and consists mainly of a sophisticated network of brain endothelial cells that forms blood vessels and selectively moves molecules inside and outside the brain ...
Enrique Estudillo, Adolfo López-Ornelas, Alejandro Rodríguez-Oviedo, Neptali Gutiérrez de la Cruz, Marco Antonio Vargas-Hernández, Adriana Jiménez   +5 more
doaj   +1 more source

Differential Effects of Normoxic versus Hypoxic Derived Breast Cancer Paracrine Factors on Brain Endothelial Cells

Biology, 2021
Background: The blood-brain barrier (BBB) is a central nervous system protective barrier formed primarily of endothelial cells that regulate the entry of substances and cells from entering the brain.
Mariam Rado, Brian Flepisi, David Fisher
doaj   +1 more source

Activated Brain Endothelial Cells Cross-Present Malaria Antigen. [PDF]

PLoS Pathogens, 2015
In the murine model of cerebral malaria caused by P. berghei ANKA (PbA), parasite-specific CD8+ T cells directly induce pathology and have long been hypothesized to kill brain endothelial cells that have internalized PbA antigen.
Shanshan W Howland, Chek Meng Poh, Laurent Rénia   +2 more
doaj   +1 more source