Results 41 to 50 of about 6,284,362 (305)
"In vitro" models of the blood-brain barrier : applications and evaluation of a new human immortalized brain capillary endothelial cell line [PDF]
, 2006 An optimal in vitro permeability screening model for the evaluation of BBB drug permeability accounts for active and passive transport processes, as well as for nondefined drug-cell interactions.
Kusch-Poddar, Manisha
core +1 more source
Journal of Neuroinflammation, 2023 Vascular endothelial function is challenged during cerebral ischemia and reperfusion. The endothelial responses are involved in inflammatory leukocyte attraction, adhesion and infiltration, blood–brain barrier leakage, and angiogenesis.
Maria Arbaizar-Rovirosa +11 more
doaj +1 more source
Brain homeostasis : VEGF receptor 1 and 2 ; two unequal brothers in mind [PDF]
, 2013 Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood.
Karl H. Plate +5 more
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Low dose cranial irradiation-induced cerebrovascular damage is reversible in mice. [PDF]
PLoS ONE, 2014 BACKGROUND: High-dose radiation-induced blood-brain barrier breakdown contributes to acute radiation toxicity syndrome and delayed brain injury, but there are few data on the effects of low dose cranial irradiation.
Nikolett Sándor +10 more
doaj +1 more source
"In vitro" evaluation of blood-brain barrier transport [PDF]
, 2014 The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
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Pharmaceutics, 2020 Cell-surface proteins that can endocytose into brain microvascular endothelial cells serve as promising candidates for receptor-mediated transcytosis across the blood–brain barrier (BBB).
Shingo Ito +6 more
doaj +1 more source
Endothelial Glycocalyx on Brain Endothelial Cells is Lost in Experimental Cerebral Malaria [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2014 We hypothesized that the glycocalyx, which is important for endothelial integrity, is lost in severe malaria. C57BL/6 mice were infected with Plasmodium berghei ANKA, resulting in cerebral malaria, or P. chabaudi AS, resulting in uncomplicated malaria.
Hempel, Casper +2 more
openaire +3 more sources
Nanoparticle accumulation and transcytosis in brain endothelial cell layers [PDF]
Nanoscale, 2013 The blood-brain barrier (BBB) is a selective barrier, which controls and limits access to the central nervous system (CNS). The selectivity of the BBB relies on specialized characteristics of the endothelial cells that line the microvasculature, including the expression of intercellular tight junctions, which limit paracellular permeability.
Ye, Dong +6 more
openaire +5 more sources
Effects of Fullerenols on Mouse Brain Microvascular Endothelial Cells [PDF]
International Journal of Molecular Sciences, 2017 Fullerenols, water-soluble C60-fullerene derivatives, have been shown to exert neuroprotective effects in vitro and in vivo, most likely due to their capability to scavenge free radicals. However, little is known about the effects of fullerenols on the blood–brain barrier (BBB), especially on cerebral endothelial cells under inflammatory conditions ...
Schuhmann, Michael K., Fluri, Felix
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Genetic manipulation of brain endothelial cells in vivo
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2016 Abstract Brain endothelial cells take center stage of the blood–brain barrier. They maintain homeostasis in the central nervous system (CNS) and are involved in the pathophysiology of many neurological diseases. So far investigations of their function have largely depended on in vitro models that lack the important impact of other cells and ...
Assmann, Julian C. +2 more
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