Results 1 to 10 of about 891,835 (120)

Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing

Stem Cell Research & Therapy, 2020
Background Cell therapy has been evaluated pre-clinically and clinically as a means to improve wound vascularization and healing. While translation of this approach to clinical practice ideally requires the availability of clinical grade xenobiotic-free ...
Bart Vaes, Ellen Van Houtven, Ellen Caluwé, Aernout Luttun   +3 more
doaj   +1 more source

Matrix Stiffness Affects Glycocalyx Expression in Cultured Endothelial Cells

Frontiers in Cell and Developmental Biology, 2021
Rationale: The endothelial cell glycocalyx (GCX) is a mechanosensor that plays a key role in protecting against vascular diseases. We have previously shown that age/disease mediated matrix stiffness inhibits the glycocalyx glycosaminoglycan heparan ...
Marwa Mahmoud, Limary Cancel, John M. Tarbell   +2 more
doaj   +1 more source

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

eLife, 2023
Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions.
Danielle B Buglak, Pauline Bougaran, Molly R Kulikauskas, Ziqing Liu, Elizabeth Monaghan-Benson, Ariel L Gold, Allison P Marvin, Andrew Burciu, Natalie T Tanke, Morgan Oatley, Shea N Ricketts, Karina Kinghorn, Bryan N Johnson, Celia E Shiau, Stephen Rogers, Christophe Guilluy, Victoria L Bautch   +16 more
doaj   +1 more source

Epigenetic landscape reveals MECOM as an endothelial lineage regulator

Nature Communications, 2023
A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine. Recent studies found that unique epigenetic signatures preferentially regulate cell identity genes.
Jie Lv, Shu Meng, Qilin Gu, Rongbin Zheng, Xinlei Gao, Jun-dae Kim, Min Chen, Bo Xia, Yihan Zuo, Sen Zhu, Dongyu Zhao, Yanqiang Li, Guangyu Wang, Xin Wang, Qingshu Meng, Qi Cao, John P. Cooke, Longhou Fang, Kaifu Chen, Lili Zhang   +19 more
doaj   +1 more source

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function

Biology Open, 2017
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined.
Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam   +6 more
doaj   +1 more source

Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation

Cells, 2014
Rab GTPases are implicated in endosome-to-plasma membrane recycling, but how such membrane traffic regulators control vascular endothelial growth factor receptor 2 (VEGFR2/KDR) dynamics and function are not well understood.
Helen M. Jopling, Adam F. Odell, Caroline Pellet-Many, Antony M. Latham, Paul Frankel, Asipu Sivaprasadarao, John H. Walker, Ian C. Zachary, Sreenivasan Ponnambalam   +8 more
doaj   +1 more source

Activation of the NFκB signaling pathway in IL6+CSF3+ vascular endothelial cells promotes the formation of keloids

Frontiers in Bioengineering and Biotechnology, 2022
Background: Keloid is a disease caused by abnormal proliferation of skin fibres, the causative mechanism of which remains unclear.Method: In this study, endothelial cells of keloids were studied using scRNAseq combined with bulk-RNAseq data from keloids.
Delin Liu, Delin Liu, Yidi Zhang, Lisha Zhen, Lisha Zhen, Rong Xu, Zhenling Ji, Zheng Ye   +7 more
doaj   +1 more source

The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease

Cardiology Research and Practice, 2012
Cardiovascular disease is the leading cause of death. The disease is due to atherosclerosis which is characterized by lipid and fat accumulation in arterial blood vessel walls. A key causative event is the accumulation of oxidised low density lipoprotein
M. W Twigg, K. Freestone, S. Homer-Vanniasinkam, S. Ponnambalam   +3 more
doaj   +1 more source

Scavenger Receptor Structure and Function in Health and Disease

Cells, 2015
Scavenger receptors (SRs) are a ‘superfamily’ of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous ...
Izma Abdul Zani, Sam L. Stephen, Nadeem A. Mughal, David Russell, Shervanthi Homer-Vanniasinkam, Stephen B. Wheatcroft, Sreenivasan Ponnambalam   +6 more
doaj   +1 more source

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

Biology Open, 2016
Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development.
Gareth W. Fearnley, Gina A. Smith, Izma Abdul-Zani, Nadira Yuldasheva, Nadeem A. Mughal, Shervanthi Homer-Vanniasinkam, Mark T. Kearney, Ian C. Zachary, Darren C. Tomlinson, Michael A. Harrison, Stephen B. Wheatcroft, Sreenivasan Ponnambalam   +11 more
doaj   +1 more source