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Endothelial Cell Transplantation
Cell Transplantation, 1995 Endothelial cells line the lumenal surface of al) elements of the vascular system. These cells exhibit numerous metabolic functions necessary for the maintenance of homeostasis. The critical role of endothelium in maintaining normal blood vessel function
Stuart K. Williams
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Endothelial Cell Metabolism [PDF]
Physiological Reviews, 2018 Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are active players in the formation of new blood vessels (angiogenesis) both in health and (life-threatening) diseases. Recently, a new concept arose by which EC metabolism drives angiogenesis in parallel to well-established angiogenic growth factors (e.g., vascular
Eelen, Guy +5 more
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Endothelial Progenitors Exist within the Kidney and Lung Mesenchyme [PDF]
, 2013 The renal endothelium has been debated as arising from resident hemangioblast precursors that transdifferentiate from the nephrogenic mesenchyme (vasculogenesis) and/or from invading vessels (angiogenesis).
Bates, CM +7 more
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Endothelial cell junctions [PDF]
The Journal of Cell Biology, 1975 In the course of a freeze-cleave study on intercellular junctions in the regenerating rat liver, we observed an unusual array of intramembranous particles located in regions of contact between endothelial cells lining the hepatic sinusoids. These arrays were characterized by an accumulation of particles which resembled a zonula occludens in their ...
Yee, Ann G., Revel, Jean-Paul
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Stem Cell Research & Therapy, 2020 Background Cell therapy has been evaluated pre-clinically and clinically as a means to improve wound vascularization and healing. While translation of this approach to clinical practice ideally requires the availability of clinical grade xenobiotic-free ...
Bart Vaes +3 more
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Matrix Stiffness Affects Glycocalyx Expression in Cultured Endothelial Cells
Frontiers in Cell and Developmental Biology, 2021 Rationale: The endothelial cell glycocalyx (GCX) is a mechanosensor that plays a key role in protecting against vascular diseases. We have previously shown that age/disease mediated matrix stiffness inhibits the glycocalyx glycosaminoglycan heparan ...
Marwa Mahmoud +2 more
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eLife, 2023 Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions.
Danielle B Buglak +16 more
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Epigenetic landscape reveals MECOM as an endothelial lineage regulator
Nature Communications, 2023 A comprehensive understanding of endothelial cell lineage specification will advance cardiovascular regenerative medicine. Recent studies found that unique epigenetic signatures preferentially regulate cell identity genes.
Jie Lv +19 more
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Positive and negative regulation of angiogenesis by soluble vascular endothelial growth factor receptor-1 [PDF]
, 2018 Vascular endothelial growth factor receptor (VEGFR)-1 exists in different forms, derived from alternative splicing of the same gene. In addition to the transmembrane form, endothelial cells produce a soluble VEGFR-1 (sVEGFR-1) isoform, whereas non ...
Carbo, Miriam +2 more
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Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function
Biology Open, 2017 Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined.
Gina A. Smith +6 more
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