Results 21 to 30 of about 1,372,494 (310)

Opening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration

open access: yesBiology Direct, 2023
Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca2+ signals through a mechanism organized in caveolar microdomains.
Hilda Espinoza, Xavier F. Figueroa
doaj   +1 more source

Isolation of equine endothelial cells and life cell angiogenesis assay [PDF]

open access: yes, 2014
Arterial or venous thromboses are frequent clinical complications with the risk of fatal progression. Recent studies suggest the disruption of angiogenesis in the course of thrombus resolution as the underlying pathomechanism.
Dietze, Kathrin   +5 more
core   +1 more source

VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration

open access: yesBiology Open, 2015
Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist but their physiological significance is unclear.
Gareth W. Fearnley   +3 more
doaj   +1 more source

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. [PDF]

open access: yes, 2019
Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease.
Aydin, Sidar   +16 more
core   +1 more source

Tumor Endothelial Cells [PDF]

open access: yesCold Spring Harbor Perspectives in Medicine, 2011
The vascular endothelium is a dynamic cellular “organ” that controls passage of nutrients into tissues, maintains the flow of blood, and regulates the trafficking of leukocytes. In tumors, factors such as hypoxia and chronic growth factor stimulation result in endothelial dysfunction.
openaire   +2 more sources

Scavenger Receptors and Their Potential as Therapeutic Targets in the Treatment of Cardiovascular Disease

open access: yesInternational Journal of Hypertension, 2010
Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of ...
Sam L. Stephen   +7 more
doaj   +1 more source

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking

open access: yesCells, 2018
Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis
William R. Critchley   +5 more
doaj   +1 more source

Endothelial cells, endoplasmic reticulum stress and oxysterols [PDF]

open access: yes, 2017
Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis.
Canonico, B.   +10 more
core   +3 more sources

Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation

open access: yesFrontiers in Physiology, 2022
Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of ion channels that contribute to Cell-Cell communication in the microcirculation.
William F. Jackson
doaj   +1 more source

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]

open access: yes, 2019
Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An   +8 more
core   +2 more sources

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