Results 1 to 10 of about 60,331 (176)

GV21 enables ultrasound molecular imaging of tumor cell-associated VEGFR2 for early therapy assessment. [PDF]

Mater Today Bio
Vascular endothelial growth factor receptor 2 (VEGFR2) plays a crucial role in tumor growth through accelerating tumor angiogenesis. Recently, increasing evidence indicates that VEGFR2 is also overexpressed on tumor cells in multiple cancers ...
Liang X, Lu S, Yang L, Zhou J, Yan F.
europepmc   +2 more sources

Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent

Acta Pharmaceutica Sinica B, 2020
Angiogenesis is an essential process in tumor growth, invasion and metastasis. VEGF receptor 2 (VEGFR2) inhibitors targeting tumor angiogenic pathway have been widely used in the clinical cancer treatment.
Jing Liu, Qingsong Liu, Cheng Chen
exaly   +3 more sources

Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

Cell Reports, 2020
Summary: Anti-angiogenic treatment targeting vascular endothelial growth factor (VEGF)-VEGFR2 signaling has shown limited efficacy in lung cancer patients.
Sven Borchmann, Daniel Rauh, Alexandra Florin   +2 more
exaly   +3 more sources

Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling

Cell Reports, 2019
Summary: The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs).
Vijay Avin Balaji Ragunathrao, Kishore K Wary, Md Zahid Akhter   +2 more
exaly   +3 more sources

Increased Vascular Endothelial Growth Factor Receptor 2 Levels Are Associated With a Higher Occurrence of Coronary Artery Disease in Patients With Obstructive Sleep Apnea. [PDF]

Rev Cardiovasc Med
Background: Obstructive sleep apnea (OSA) has become a vital risk factor for coronary artery disease (CAD). Vascular endothelial growth factor receptor 2 (VEGFR2) participates in the mediation of atherosclerosis, the main underlying ...
Zhu J, Wu D, Chen S, Pan Y, Jiao X, Fu G.   +5 more
europepmc   +2 more sources

Expression of Diverse Angiogenesis Factor in Different Stages of the 4T1 Tumor as a Mouse Model of Triple-Negative Breast Cancer [PDF]

Advanced Pharmaceutical Bulletin, 2020
Purpose: Triple-negative breast cancer (TNBC) is specified by high vascularity and repetitious metastasis. Although several studies have indicated that angiogenesis has an important role in invasive breast cancer, a suitable model of TNBC that can show ...
Saba Malekian, Marveh Rahmati, Soyar Sari, Monireh Kazemimanesh, Raheleh Kheirbakhsh, Ahad Muhammadnejad, Saeid Amanpour   +6 more
doaj   +1 more source

Analysis of VEGF-A/VEGFR1/VEGFR2 gene expression in patients with myelodysplastic syndrome [PDF]

Терапевтический архив, 2017
Aim. To assess the significance of gene expression of the vascular endothelial growth factor-A (VEGF-A) and its interacting receptors VEGFR1 and VEGFR2 as potential diagnostic and prognostic molecular markers in patients with myelodysplastic syndrome ...
N N Kalitin, G A Dudina, S V Semochkin, A F Karamysheva   +3 more
doaj   +1 more source

Key VEGF signaling system components and matrix metalloproteinases in the diagnosis and prognosis of overall survival of patients with renal cell cancer

Alʹmanah Kliničeskoj Mediciny, 2020
Background: Evaluation and search for new molecular markers of renal cell cancer, first of all, associated with angiogenic and invasive activity, continue to be highly relevant.
N. E. Kushlinskii, E. S. Gershtein, A. V. Kolpakov, S. D. Bezhanova, V. V. Mushtenko, E. A. Korotkova, D. Yu. Pushkar, V. V. Bazaev   +7 more
doaj   +1 more source

Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways

Biology Open, 2021
The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required for angiogenesis resulting in sprouting and pruning of vessels to generate mature arborizing structures.
Grace X. Li, Shaobing Zhang, Ren Liu, Bani Singh, Sukhmani Singh, David I. Quinn, Gage Crump, Parkash S. Gill   +7 more
doaj   +1 more source

Adropin exerts neuroprotection in an experimental rat model of Parkinson’s disease [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study was planned to elucidate the mechanism of the protective effect of adropin in an experimental rat model of Parkinson’s Disease (PD).
Ayse Ozkan, Hande Parlak, Osman Sinen, Mehmet Bulbul, Mutay Aydin Aslan, Aysel Ağar   +5 more
doaj   +1 more source