Results 21 to 30 of about 60,331 (176)

Research Progress of Combination Therapy of Apatinib on Tumor

Zhongliu Fangzhi Yanjiu, 2019
Angiogenesis plays an important role in tumor growth and metastasis, and vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulatory factor in the process of angiogenesis.
WU Shan, HUA Zhan, LI Jianchen, ZHOU Jianjun, WANG Zai   +4 more
doaj   +1 more source

VEGFR2 translocates to the nucleus to regulate its own transcription. [PDF]

PLoS ONE, 2011
Vascular Endothelial Growth Factor Receptor-2 (VEGFR2) is the major mediator of the angiogenic effects of VEGF. In addition to its well known role as a membrane receptor that activates multiple signaling pathways, VEGFR2 also has a nuclear localization ...
Inês Domingues, José Rino, Jeroen A A Demmers, Primal de Lanerolle, Susana Constantino Rosa Santos   +4 more
doaj   +1 more source

Inhibition of LPA-LPAR1 and VEGF-VEGFR2 Signaling in IPF Treatment

Drug Design, Development and Therapy, 2023
Ya-Li Luo,* Yan Li,* Wen Zhou, Si-Yu Wang, Yong-Qi Liu Gansu University Key Laboratory for Molecular Medicine and Chinese Medicine Prevention and Treatment of Major Diseases, Gansu University of Chinese Medicine, Lanzhou, 730000, People’s ...
Luo YL, Li Y, Zhou W, Wang SY, Liu YQ
doaj  

Differentiation and subpopulation composition of VEGFR2+ cells in the blood and bone marrow in ischemic cardiomyopathy

Бюллетень сибирской медицины, 2022
Aim. To identify disturbances of differentiation and subpopulation composition of VEGFR2+ cells in the blood and bone marrow associated with the features of the cytokine profile in the blood and bone marrow in patients with coronary artery disease (CAD ...
S. P. Chumakova, O. I. Urazova, V. M. Shipulin, O. A. Denisenko, T. E. Kononova, K. V. Nevskaya, S. L. Andreev   +6 more
doaj   +1 more source

Apatinib has anti-tumor effects and induces autophagy in lung cancer cells with high expression of VEGFR-2 [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study investigated the inhibitory effect of apatinib on lung cancer cells with high expression of vascular endothelial growth factor-2 (VEGFR-2) and on inducing cellular autophagy and drug resistance.
Mingtao Liu, Hui Li
doaj   +1 more source

Prognostic significance of AKT/mTOR signaling pathway components, transcription factors, and growth factors in the development of skin melanoma recurrence

Южно-Российский онкологический журнал
Purpose of the study. Was to investigate the prognostic significance of the AKT/mTOR signaling pathway components, transcription, and growth factors in the development of skin melanoma recurrence.Patients and methods.
V. A. Bogdanova, L. V. Spirina, S. Yu. Chizhevskaya, I. V. Kovaleva, K. V. Nikulnikov, E. D. Merkulov   +5 more
doaj   +1 more source

S1PR1 and VEGFR2 – a synergy that promotes tumor angiogenesis?

Molecular & Cellular Oncology, 2020
We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1−/- mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling ...
Vijay Avin Balaji Ragunathrao, Vigneshwaran Vellingiri, Mumtaz Anwar, Md Zahid Akhter, Dolly Mehta   +4 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Anti-VEGFR2 F(ab′)2 drug conjugate promotes renal accumulation and glomerular repair in diabetic nephropathy

Nature Communications, 2023
Poor renal distribution of antibody-based drugs is the key factor contributing to low treatment efficiency for renal diseases and side effects. Here, we prepare F(ab′)2 fragmented vascular endothelial growth factor receptor 2 antibody (anti-VEGFR2 (F(ab′)
Di Liu, Yanling Song, Hui Chen, Yuchan You, Luwen Zhu, Jucong Zhang, Xinyi Xu, Jiahao Hu, Xiajie Huang, Xiaochuan Wu, Xiaoling Xu, Saiping Jiang, Yongzhong Du   +12 more
doaj   +1 more source

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source