Mechanisms of Thrombocytosis in Iron-Deficiency Anemia. [PDF]
Eur J HaematolABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
Facco JV, Krause DS, Olalla Saad ST.
europepmc +2 more sources
VEGFR Blockade Reduces <i>Mycobacterium tuberculosis</i>-Induced Lung Pathology in Immunocompromised Mice. [PDF]
CellsMycobacterium tuberculosis (Mtb) remains a significant public health threat, responsible for 1.6 million deaths in 2021. The development of new treatments is particularly urgent for immunocompromised individuals, including those with Mtb/HIV coinfection,
Herbath M +6 more
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FEBS Open Bio, 2020 We previously demonstrated that a deficiency of natural antibodies against CD25, Mucin 1 (MUC1), and vascular endothelial growth factor receptor 1 (VEGFR1) could contribute to high risk of non‐small cell lung cancer (NSCLC).
Xuan Zhang, Xuan Zhang, Quanhang Jiang
exaly +2 more sources
Methionine induced placental angiogenesis through activating WNT3A/CTNNB1-PIGF-VEGFR1 pathway. [PDF]
Cell Commun SignalBackground Placenta is highly susceptible to oxidative stress during pregnancy, which is a major cause of abnormal vascular development, fetal growth restriction and preterm birth.
Zou Y +9 more
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Expression of Diverse Angiogenesis Factor in Different Stages of the 4T1 Tumor as a Mouse Model of Triple-Negative Breast Cancer [PDF]
Advanced Pharmaceutical Bulletin, 2020 Purpose: Triple-negative breast cancer (TNBC) is specified by high vascularity and repetitious metastasis. Although several studies have indicated that angiogenesis has an important role in invasive breast cancer, a suitable model of TNBC that can show ...
Saba Malekian +6 more
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VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepatic ischemia/reperfusion injury. [PDF]
PLoS ONE, 2014 Liver repair after acute liver injury is characterized by hepatocyte proliferation, removal of necrotic tissue, and restoration of hepatocellular and hepatic microvascular architecture.
Hirotoki Ohkubo +9 more
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Analysis of VEGF-A/VEGFR1/VEGFR2 gene expression in patients with myelodysplastic syndrome [PDF]
Терапевтический архив, 2017 Aim. To assess the significance of gene expression of the vascular endothelial growth factor-A (VEGF-A) and its interacting receptors VEGFR1 and VEGFR2 as potential diagnostic and prognostic molecular markers in patients with myelodysplastic syndrome ...
N N Kalitin +3 more
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Alʹmanah Kliničeskoj Mediciny, 2020 Background: Evaluation and search for new molecular markers of renal cell cancer, first of all, associated with angiogenic and invasive activity, continue to be highly relevant.
N. E. Kushlinskii +7 more
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Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. [PDF]
PLoS Medicine, 2007 While vascular endothelial growth factor (VEGF) expression in breast tumors has been correlated with a poor outcome in the pathogenesis of breast cancer, the expression, localization, and function of VEGF receptors VEGFR1 (also known as FLT1) and VEGFR2 (
Tae-Hee Lee +6 more
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A paradoxical method to enhance compensatory lung growth: Utilizing a VEGF inhibitor. [PDF]
PLoS ONE, 2018 Exogenous vascular endothelial growth factor (VEGF) accelerates compensatory lung growth (CLG) in mice after unilateral pneumonectomy. In this study, we unexpectedly discovered a method to enhance CLG with a VEGF inhibitor, soluble VEGFR1. Eight-week-old
Duy T Dao +12 more
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