Results 21 to 30 of about 14,079 (176)

Treatment with placental growth factor attenuates myocardial ischemia/reperfusion injury. [PDF]

PLoS ONE, 2018
Studies have established that oxidative stress plays an important role in the pathology of myocardial ischemia/reperfusion injury (MIRI). Vascular endothelial growth factor receptor 1 (VEGFR1) activation was reported to reduce oxidative stress and ...
Yabing Zhang, Chang Cao, Juan Xin, Peilin Lv, Dongxu Chen, Shiyue Li, Hui Yang, Chan Chen, Bin Liu, Qian Li   +9 more
doaj   +1 more source

Flt1/VEGFR1 heterozygosity causes transient embryonic edema [PDF]

Scientific Reports, 2016
AbstractVascular endothelial growth factor-A is a major player in vascular development and a potent vascular permeability factor under physiological and pathological conditions by binding to a decoy receptor Flt1 and its primary receptor Flk1.
Otowa, Yasunori, Moriwaki, Kazumasa, Sano, Keigo, Shirakabe, Masanori, Yonemura, Shigenobu, Shibuya, Masabumi, Rossant, Janet, Suda, Toshio, Kakeji, Yoshihiro, Hirashima, Masanori   +9 more
openaire   +3 more sources

Interaction between PD-L1 and soluble VEGFR1 in glioblastoma-educated macrophages

BMC Cancer, 2023
Purpose The combined application of immune checkpoint inhibitors (ICIs) and anti-angiogenesis therapy has shown synergistic effects on glioblastoma (GBM).
Xin Liu, Zhenke Li, Jinxing Sun, Zhijie Zhang, Weiguo Li   +4 more
doaj   +1 more source

VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation.

PLoS ONE, 2009
The role of vascular endothelial growth factor receptor 1 (VEGFR1/Flt1) in tumor metastasis remains incompletely characterized. Recent reports suggested that blocking VEGFR1 activity or the interaction with its ligands (VEGF and PlGF) has anti-tumor ...
Michelle R Dawson, Dan G Duda, Sung-Suk Chae, Dai Fukumura, Rakesh K Jain   +4 more
doaj   +1 more source

Inhibition of cell proliferation and increased-apoptosis of AGS and SNU-5 cancer cells following small interfering RNA (siRNA)-mediated down-regulation of vascular endothelial growth factor receptor 1 (VEGFR1)

Chronic Diseases Journal, 2018
BACKGROUND: Angiogenesis is vital for development of normal tissue and wound healing; but it play an important role in development of some diseases such as different types of cancer.
Esmaeil Rahimi, Saman Esmaeilnejad, Iman Sadeghi   +2 more
doaj   +1 more source

VEGF Receptor 1 Promotes Hypoxia-Induced Hematopoietic Progenitor Proliferation and Differentiation

Frontiers in Immunology, 2022
Although it is well known that hypoxia incites unleashed cellular inflammation, the mechanisms of exaggerated cellular inflammation in hypoxic conditions are not known. We observed augmented proliferation of hematopoietic stem and progenitor cells (HSPC),
Jonathan Florentin, Scott P. O’Neil, Lee L. Ohayon, Afaz Uddin, Sathish Babu Vasamsetti, Anagha Arunkumar, Samit Ghosh, Jennifer C. Boatz, Justin Sui, Corrine R. Kliment, Stephen Y. Chan, Partha Dutta, Partha Dutta   +12 more
doaj   +1 more source

Trafficking dynamics of VEGFR1, VEGFR2, and NRP1 in human endothelial cells

PLOS Computational Biology, 2022
The vascular endothelial growth factor (VEGF) family of cytokines are key drivers of blood vessel growth and remodeling. These ligands act via multiple VEGF receptors (VEGFR) and co-receptors such as Neuropilin (NRP) expressed on endothelial cells. These membrane-associated receptors are not solely expressed on the cell surface, they move between the ...
Sarvenaz Sarabipour, Karina Kinghorn, Kaitlyn M. Quigley, Anita Kovacs-Kasa, Brian H. Annex, Victoria L. Bautch, Feilim Mac Gabhann   +6 more
openaire   +4 more sources

Altered levels of circulating natural antibodies against VEGFR1-derived peptide in atherosclerosis

Journal of International Medical Research, 2020
Background Several lines of evidence have pointed to a protective role of natural antibodies in chronic diseases like atherosclerosis and cancer. Vascular endothelial growth factor receptor 1 (VEGFR1) and VEGFR2 are important regulators of angiogenesis ...
Peng Wang, Siqi Liu, Zhenqi Wang, Huan Zhao, Xuan Zhang   +4 more
doaj   +1 more source

VEGF receptor heterodimers and homodimers are differentially expressed in neuronal and endothelial cell types.

PLoS ONE, 2022
PurposeWe have previously reported that VEGF-B is more potent than VEGF-A in mediating corneal nerve growth in vitro and in vivo, and this stimulation of nerve growth appears to be different from stimulation of angiogenesis by these same ligands, at ...
Joy Sarkar, Yuncin Luo, Qiang Zhou, Evguenia Ivakhnitskaia, Daniel Lara, Eitan Katz, Michael G Sun, Victor Guaiquil, Mark Rosenblatt   +8 more
doaj   +1 more source

Lymphangiogenesis induced by vascular endothelial growth factor receptor 1 signaling contributes to the progression of endometriosis in mice

Journal of Pharmacological Sciences, 2020
Lymphangiogenesis is related to the growth of endometriosis. Here, we examined whether vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling plays a role in lymphangiogenesis during endometriosis.
Kyoko Hattori, Yoshiya Ito, Masako Honda, Kazuki Sekiguchi, Kanako Hosono, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +7 more
doaj   +1 more source