Results 11 to 20 of about 14,079 (176)
VEGFR1-tyrosine kinase signaling in pulmonary fibrosis [PDF]
Inflammation and Regeneration, 2021 Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano +4 more
doaj +3 more sources
Molecular basis of VEGFR1 autoinhibition at the plasma membrane
Nature Communications, 2023 Ligand-independent activation of VEGFRs is a hallmark of diabetes and several cancers. Like EGFR, VEGFR2 is activated spontaneously at high receptor concentrations. VEGFR1, on the other hand, remains constitutively inactive in the unligated state, making
Manas Pratim Chakraborty +6 more
doaj +3 more sources
Accelerated coronary angiogenesis by vegfr1-knockout endocardial cells. [PDF]
PLoS ONE, 2013 During mouse heart development, ventricular endocardial cells give rise to the coronary arteries by angiogenesis. Myocardially-derived vascular endothelial growth factor-a (Vegfa) regulates embryonic coronary angiogenesis through vascular endothelial ...
Zheng Zhang, Bin Zhou
doaj +4 more sources
VEGFR1 and VEGFR2 in Alzheimer’s Disease [PDF]
Journal of Alzheimer's Disease, 2017 Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. Despite upregulation of VEGF in the brain in Alzheimer’s disease (AD), probably in response to amyloid-β, vasoconstriction, and tissue hypoxia, there is no consequent increase in microvessel density.
Harris, Rachel +3 more
openaire +3 more sources
VEGFR1-activity-independent metastasis formation [PDF]
Nature, 2009 Molecules such as vascular endothelial growth factor (VEGF) or placental growth factor-critical regulators of tumour angiogenesis-are also thought to mobilize into blood circulation bone marrow-derived cells (BMDCs), which may subsequently be recruited to tumours and facilitate tumour growth and metastasis.
Michelle R, Dawson +3 more
openaire +2 more sources
On the relationship of LDL and VEGFR1: not just a family affair [PDF]
The EMBO Reports, 2007 In this issue of EMBO reports , Usui et al (2007) report their findings of ligand‐independent activation of vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) by low‐density lipoprotein (LDL). Thus far, VEGFR1 has been shown to be activated only by members of the VEGF ligand family, including VEGF‐A, VEGF‐B and placenta growth factor (PlGF).
Seppo, Ylä-Herttuala, Kari, Alitalo
openaire +2 more sources
Expression of VEGF receptors on endothelial cells in mouse skeletal muscle. [PDF]
PLoS ONE, 2012 VEGFR surface localization plays a critical role in converting extracellular VEGF signaling towards angiogenic outcomes, and the quantitative characterization of these parameters is critical for advancing computational models; however the levels of these
Princess I Imoukhuede +1 more
doaj +1 more source
VEGFR1 for Lymphangiogenesis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 The lymphatic vascular system is a conduit for interstitial fluid extravasated from blood vessels and also plays important roles in maintaining immune responses, lipid uptake, and tissue homeostasis. In recent years, much attention has been given to lymphangiogenesis, a formation of new lymphatic vessels, because lymphangiogenesis has been shown to be ...
openaire +1 more source
The Role of Vascular Endothelial Growth Factor Receptor-1 Signaling in the Recovery from Ischemia. [PDF]
PLoS ONE, 2015 Vascular endothelial growth factor (VEGF) is one of the most potent angiogenesis stimulators. VEGF binds to VEGF receptor 1 (VEGFR1), inducing angiogenesis through the receptor's tyrosine kinase domain (TK), but the mechanism is not well understood.
Hideki Amano +10 more
doaj +1 more source
VEGFR1 and VEGFR2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis. [PDF]
PLoS ONE, 2013 AIM: Accumulating evidence suggests that extracellular galectin-1 and galectin-3 promote angiogenesis. Increased expression of galectin-1 and/or galectin-3 has been reported to be associated with tumour progression. Thus, it is critical to identify their
Nicky D'Haene +7 more
doaj +1 more source