Results 31 to 40 of about 14,079 (176)

VEGF Receptor 1-Expressing Macrophages Recruited from Bone Marrow Enhances Angiogenesis in Endometrial Tissues

Scientific Reports, 2019
Angiogenesis is critical in maintenance of endometrial tissues. Here, we examined the role of VEGF receptor 1 (VEGFR1) signaling in angiogenesis and tissue growth in an endometriosis model. Endometrial fragments were implanted into the peritoneal wall of
Kazuki Sekiguchi, Yoshiya Ito, Kyoko Hattori, Tomoyoshi Inoue, Kanako Hosono, Masako Honda, Akiko Numao, Hideki Amano, Masabumi Shibuya, Nobuya Unno, Masataka Majima   +10 more
doaj   +1 more source

Changes in VEGFR1 and VEGFR2 expression and endothelial cell maturity in laboratory animals with a model of Alzheimer’s disease

Бюллетень сибирской медицины
Aim. To evaluate the expression of VEGFR1 and VEGFR2 and the maturity of endothelial cells in neurogenic niches in the model of Alzheimer’s disease.Materials and methods. The study was carried out on 6-month-old male C57BL/6 mice. The experimental group (
M. V. Kukla, A. S. Averchuk, A. V. Stavrovskaya, N. A. Rozanova, A. K. Berdnikov, N. A. Kolotyeva, A. B. Salmina   +6 more
doaj   +1 more source

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1 [PDF]

Nature Communications, 2017
Abstract Pericytes adhere to the abluminal surface of endothelial tubules and are required for the formation of stable vascular networks. Defective endothelial cell-pericyte interactions are frequently observed in diseases characterized by compromised vascular integrity such as diabetic retinopathy.
Hanna M. Eilken, Rodrigo Diéguez-Hurtado, Inga Schmidt, Masanori Nakayama, Hyun-Woo Jeong, Hendrik Arf, Susanne Adams, Napoleone Ferrara, Ralf H. Adams   +8 more
openaire   +6 more sources

Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration

Cell Reports, 2019
Summary: After a peripheral nerve lesion, distal ends of injured axons disintegrate into small fragments that are subsequently cleared by Schwann cells and later by macrophages.
Adrien Vaquié, Alizée Sauvain, Mert Duman, Gianluigi Nocera, Boris Egger, Felix Meyenhofer, Laurent Falquet, Luca Bartesaghi, Roman Chrast, Christophe Maurice Lamy, Seokyoung Bang, Seung-Ryeol Lee, Noo Li Jeon, Sophie Ruff, Claire Jacob   +14 more
doaj   +1 more source

Binding of VEGF-A to canine cancer cells with preferential expression of VEGFR1 [PDF]

Veterinary World, 2014
Aim: Despite encouraging results in syngeneic and xenografts cancer models with various inhibitors of vascular endothelial growth factor (VEGF) or its receptors (VEGFRs), beneficial effects have not been consistently translated to the clinic ...
Antonella Borgatti, , Megan Duckett, , Charles Spangler , Jaime F. Modiano   +3 more
doaj   +1 more source

The importance of markers of osteolysis and osteogenesis in the pathogenesis of cephalohematoma in newborns

Acta Biomedica Scientifica
Background. Of particular importance in the repair process for cephalohematomas is the pathological remodeling of the bones of the cranial vault. Local changes in the bones of the skull are accompanied by the processes of osteolysis and osteogenesis and ...
R. A. Sushchenko, A. S. Panchenko
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Targeting Anti-Angiogenic VEGF₁₆₅b–VEGFR1 Signaling Promotes Nitric Oxide Independent Therapeutic Angiogenesis in Preclinical Peripheral Artery Disease Models

Cells, 2022
Nitric oxide (NO) is the critical regulator of VEGFR2-induced angiogenesis. Neither VEGF-A over-expression nor L-Arginine (NO-precursor) supplementation has been effective in helping patients with Peripheral Artery Disease (PAD) in clinical trials.
Sivaraman Kuppuswamy, Brian H. Annex, Vijay C. Ganta   +2 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source