Results 41 to 50 of about 60,331 (176)

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Galectin-3 Enhances Vascular Endothelial Growth Factor-A Receptor 2 Activity in the Presence of Vascular Endothelial Growth Factor

Frontiers in Cell and Developmental Biology, 2021
Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction.
Issahy Cano, Issahy Cano, Zhengping Hu, Zhengping Hu, Dina B. AbuSamra, Dina B. AbuSamra, Magali Saint-Geniez, Magali Saint-Geniez, Yin Shan Eric Ng, Yin Shan Eric Ng, Pablo Argüeso, Pablo Argüeso, Patricia A. D’Amore, Patricia A. D’Amore, Patricia A. D’Amore   +14 more
doaj   +1 more source

Molecular mechanism of Xanthotoxol against gastric cancer: A comprehensive study integrating network pharmacology, computer simulations, and experimental validation

Animal Models and Experimental Medicine, EarlyView.
Our study systematically explored the anti‐gastric cancer (GC) mechanism of Xanthotoxol (Xan), a natural active phytochemical, using an integrated strategy of network pharmacology, molecular simulation, and experimental validation. First, we identified 39 hub genes associated with gastric cancer using weighted gene co‐expression network analysis (WGCNA)
Yi Yang, Yu‐Hua Du, Chuang Song, Lan‐Nv Ma, Lin Luo, De‐Xu Xu, Xiao‐Yan Ma, Zi‐Ying Zhou, Yi Nan, Yi Yang, Ling Yuan   +10 more
wiley   +1 more source

MOLECULAR DOCKING ANALYSIS OF THE BIOACTIVE COMPOUND EMODIN WITH VEGFR2 IN CERVICAL CANCER

Jurnal Kedokteran dan Kesehatan
Cervical cancer remains a leading cause of cancer-related mortality among women and represents the third most common cancer globally. Elevated VEGF expression in cervical cancer is associated with poor prognosis, highlighting the relevance of anti-VEGF ...
Innayah Rania Farzana, Rara Inggarsih, Ziske Maritska, Ayeshah Augusta Rosdah, Soilia Fertilita   +4 more
doaj   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

The Protective Effects of Juglanin in Cerebral Ischemia Reduce Blood–Brain Barrier Permeability via Inhibition of VEGF/VEGFR2 Signaling

Drug Design, Development and Therapy, 2020
Jia Liu,1 Lei Chen,2 Xin Zhang,1 Lixiao Pan,1 Lili Jiang1 1Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, People’s Republic of China; 2Department of Integrated Management, The Affiliated ...
Liu J, Chen L, Zhang X, Pan L, Jiang L
doaj  

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

RETRACTED ARTICLE: SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis

Nature Communications, 2018
Regulation of VEGFR2 represents an important mechanism for the control of angiogenesis. VEGFR2 activity can be regulated by post-translational modifications such as ubiquitination and acetylation.
Huanjiao Jenny Zhou, Zhe Xu, Zongren Wang, Haifeng Zhang, Zhen W. Zhuang, Michael Simons, Wang Min   +6 more
doaj   +1 more source

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source