Results 11 to 20 of about 858,060 (266)
Cells, 2014 Rab GTPases are implicated in endosome-to-plasma membrane recycling, but how such membrane traffic regulators control vascular endothelial growth factor receptor 2 (VEGFR2/KDR) dynamics and function are not well understood.
Helen M. Jopling +8 more
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The LOX-1 Scavenger Receptor and Its Implications in the Treatment of Vascular Disease
Cardiology Research and Practice, 2012 Cardiovascular disease is the leading cause of death. The disease is due to atherosclerosis which is characterized by lipid and fat accumulation in arterial blood vessel walls. A key causative event is the accumulation of oxidised low density lipoprotein
M. W Twigg +3 more
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Scavenger Receptor Structure and Function in Health and Disease
Cells, 2015 Scavenger receptors (SRs) are a ‘superfamily’ of membrane-bound receptors that were initially thought to bind and internalize modified low-density lipoprotein (LDL), though it is currently known to bind to a variety of ligands including endogenous ...
Izma Abdul Zani +6 more
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Endothelial Cell Heterogeneity [PDF]
Cold Spring Harbor Perspectives in Medicine, 2003 To review recent advances in the field of endothelial cell heterogeneity, and to apply this knowledge to an understanding of site-specific vasculopathy, including acute lung injury.Published research and review articles in the English language related to endothelial cell biology and endothelial cell heterogeneity.The results of published studies have ...
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VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
Biology Open, 2016 Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development.
Gareth W. Fearnley +11 more
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Neoplasia, 2006 Cancer, a proliferative disease hallmarked by abnormal cell growth and spread, is largely dependent on tumor neoangiogenesis, with evidence of vascular endothelial dysfunction. Novel ways to assess vascular function in cancer include measuring levels of circulating endothelial cells (CEC).
P.K.Y. Goon +4 more
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Biology Open, 2015 Vascular endothelial growth factor A (VEGF-A) regulates many aspects of vascular physiology such as cell migration, proliferation, tubulogenesis and cell-cell interactions. Numerous isoforms of VEGF-A exist but their physiological significance is unclear.
Gareth W. Fearnley +3 more
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International Journal of Hypertension, 2010 Scavenger receptors act as membrane-bound and soluble proteins that bind to macromolecular complexes and pathogens. This diverse supergroup of proteins mediates binding to modified lipoprotein particles which regulate the initiation and progression of ...
Sam L. Stephen +7 more
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Cells, 2018 Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis
William R. Critchley +5 more
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Endothelial Ion Channels and Cell-Cell Communication in the Microcirculation
Frontiers in Physiology, 2022 Endothelial cells in resistance arteries, arterioles, and capillaries express a diverse array of ion channels that contribute to Cell-Cell communication in the microcirculation.
William F. Jackson
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