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Single-Cell Transcriptome Atlas of Murine Endothelial Cells

Cell, 2020
The heterogeneity of endothelial cells (ECs) across tissues remains incompletely inventoried. We constructed an atlas of >32,000 single-EC transcriptomes from 11 mouse tissues and identified 78 EC subclusters, including Aqp7+ intestinal capillaries and ...
Koen Veys, Charlotte Dubois, Peter Carmeliet   +2 more
exaly   +2 more sources

Endothelial cell infection and endotheliitis in COVID-19 [PDF]

The Lancet, 2020
www.thelancet.com Published online April 17, 2020 https://doi.org/10.1016/S0140-6736(20)30937-5 1 ventilation. Echocardiography showed reduced left ventricular ejection fraction.
Z. Varga, A. Flammer, P. Steiger, M. Haberecker, Rea Andermatt, A. Zinkernagel, M. Mehra, R. Schuepbach, F. Ruschitzka, H. Moch   +9 more
semanticscholar   +3 more sources

Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology

Frontiers in Physiology, 2021
The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood ...
Zarah B. Tabrizi, Nada S. Ahmed, Joseph L. Horder, Sarah J. Storr, Andrew V. Benest   +4 more
doaj   +1 more source

Effects of RIPC on the Metabolome in Patients Undergoing Vascular Surgery: A Randomized Controlled Trial

Biomolecules, 2022
Background: remote ischemic preconditioning (RIPC) is a phenomenon in which short episodes of ischemia are applied to distant organs to prepare target organs for more prolonged ischemia and to induce protection against ischemia-reperfusion injury.
Kadri Eerik, Teele Kasepalu, Karl Kuusik, Jaan Eha, Mare Vähi, Kalle Kilk, Mihkel Zilmer, Jaak Kals   +7 more
doaj   +1 more source

Metabolomics of Arterial Stiffness

Metabolites, 2022
Arterial stiffness (AS) is one of the earliest detectable signs of structural and functional alterations of the vessel wall and an independent predictor of cardiovascular events and death.
Kaido Paapstel, Jaak Kals
doaj   +1 more source

The onset of PI3K‐related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib

EMBO Molecular Medicine, 2022
Low‐flow vascular malformations are congenital overgrowths composed of abnormal blood vessels potentially causing pain, bleeding and obstruction of different organs.
Piotr Kobialka, Helena Sabata, Odena Vilalta, Leonor Gouveia, Ana Angulo‐Urarte, Laia Muixí, Jasmina Zanoncello, Oscar Muñoz‐Aznar, Nagore G Olaciregui, Lucia Fanlo, Anna Esteve‐Codina, Cinzia Lavarino, Biola M Javierre, Veronica Celis, Carlota Rovira, Susana López‐Fernández, Eulàlia Baselga, Jaume Mora, Sandra D Castillo, Mariona Graupera   +19 more
doaj   +1 more source

Exercise-Generated β-Aminoisobutyric Acid (BAIBA) Reduces Cardiomyocyte Metabolic Stress and Apoptosis Caused by Mitochondrial Dysfunction Through the miR-208b/AMPK Pathway

Frontiers in Cardiovascular Medicine, 2022
ObjectiveTo explore the cardioprotective effects of exercise-derived β-aminoisobutyric (BAIBA) on cardiomyocyte apoptosis and energy metabolism in a rat model of heart failure (HF).MethodsIn male Sprague-Dawley rats (8-week-old), myocardial infarction ...
Yanan Yu, Yanan Yu, Wewei Chen, Wewei Chen, Ming Yu, Ming Yu, Jinsha Liu, Jinsha Liu, Huan Sun, Huan Sun, Ping Yang, Ping Yang   +11 more
doaj   +1 more source

Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing

Stem Cell Research & Therapy, 2020
Background Cell therapy has been evaluated pre-clinically and clinically as a means to improve wound vascularization and healing. While translation of this approach to clinical practice ideally requires the availability of clinical grade xenobiotic-free ...
Bart Vaes, Ellen Van Houtven, Ellen Caluwé, Aernout Luttun   +3 more
doaj   +1 more source

The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction

Cardiovascular Diabetology, 2023
Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which leads to microangiopathy and macroangiopathy and ultimately increases the mortality of diabetic patients.
Ying An, Bu-Tuo Xu, Sheng-rong Wan, Xiu M. Ma, Yang Long, Yong Xu, Zong-Zhe Jiang   +6 more
semanticscholar   +1 more source

Cerebral and systemic endothelial dysfunction in migraine: Current knowledge and perspective [PDF]

Romanian Journal of Neurology, 2021
Migraine still causes a high rate of disability and is reported to increase the risk of cardiovascular and cerebrovascular diseases. Endothelial dysfunction is considered to be one of the underlying mechanisms linking migraine and vascular disorders ...
I Made Oka Adnyana, Valentina Tjandra Dewi   +1 more
doaj   +1 more source