Results 31 to 40 of about 1,684,780 (315)

Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy

Frontiers in Endocrinology, 2022
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury.
Jing Yang, Zhang-Suo Liu
semanticscholar   +1 more source

Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension

eLife, 2020
The lymphatic vasculature is involved in the pathogenesis of acute cardiac injuries, but little is known about its role in chronic cardiac dysfunction. Here, we demonstrate that angiotensin II infusion induced cardiac inflammation and fibrosis at 1 week ...
LouJin Song, Xian Chen, Terri A Swanson, Brianna LaViolette, Jincheng Pang, Teresa Cunio, Michael W Nagle, Shoh Asano, Katherine Hales, Arun Shipstone, Hanna Sobon, Sabra D Al-Harthy, Youngwook Ahn, Steven Kreuser, Andrew Robertson, Casey Ritenour, Frank Voigt, Magalie Boucher, Furong Sun, William C Sessa, Rachel J Roth Flach   +20 more
doaj   +1 more source

Spinal cord vascular degeneration impairs duloxetine penetration

Frontiers in Pain Research, 2023
IntroductionChronic pain is a prevalent physically debilitating health-related morbidity. Frontline analgesics are inadequate, providing only partial pain relief in only a proportion of the patient cohort.
M. E Da Vitoria Lobo, R Madden, S Liddell, M Hirashima, R. P Hulse, R. P Hulse   +5 more
doaj   +1 more source

Roles of Oxidative Stress and Inflammation in Vascular Endothelial Dysfunction-Related Disease

Antioxidants, 2022
Oxidative stress and chronic inflammation play an important role in the pathogenesis of atherosclerosis. Atherosclerosis develops as the first step of vascular endothelial dysfunction induced by complex molecular mechanisms.
Y. Higashi
semanticscholar   +1 more source

Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation

Cells, 2014
Rab GTPases are implicated in endosome-to-plasma membrane recycling, but how such membrane traffic regulators control vascular endothelial growth factor receptor 2 (VEGFR2/KDR) dynamics and function are not well understood.
Helen M. Jopling, Adam F. Odell, Caroline Pellet-Many, Antony M. Latham, Paul Frankel, Asipu Sivaprasadarao, John H. Walker, Ian C. Zachary, Sreenivasan Ponnambalam   +8 more
doaj   +1 more source

The acute effect of heat exposure on forearm macro‐ and microvascular function: Impact of measurement timing, heating modality and biological sex

Experimental Physiology, 2023
The aim of this study was to gain a better understanding of the acute effect of heat exposure on brachial artery flow‐mediated dilatation (FMD) and postocclusion reactive hyperaemia (PORH) by: characterizing the time course of changes post‐heating ...
Georgia K. Chaseling, Amélie Debray, Hugo Gravel, Nicholas Ravanelli, Audrey‐Ann Bartlett, Daniel Gagnon   +5 more
doaj   +1 more source

Skeletonema marinoi Extracts and Associated Carotenoid Fucoxanthin Downregulate Pro-Angiogenic Mediators on Prostate Cancer and Endothelial Cells

Cells, 2023
The exploration of natural preventive molecules for nutraceutical and pharmaceutical use has recently increased. In this scenario, marine microorganisms represent an underestimated source of bioactive products endowed with beneficial effects on health ...
Luana Calabrone, Valentina Carlini, Douglas M. Noonan, Marco Festa, Cinzia Ferrario, Danilo Morelli, Debora Macis, Angelo Fontana, Luigi Pistelli, Christophe Brunet, Clementina Sansone, Adriana Albini   +11 more
doaj   +1 more source

A new technique to salvage myocardium following the failure of thrombus aspiration in acute myocardial infarction: a case report

BMC Cardiovascular Disorders, 2018
Background The failure of aspiration thrombectomy may negatively impact outcomes in patients with acute myocardial infarction (AMI), but the available options are limited.
Daoyuan Si, Guohui Liu, Yaliang Tong, Cheng Zhang, Yuquan He   +4 more
doaj   +1 more source

Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis

Frontiers in Cell and Developmental Biology, 2021
During development and in several diseases, endothelial cells (EC) can undergo complete endothelial-to-mesenchymal transition (EndoMT or EndMT) to generate endothelial-derived mesenchymal cells.
Jennifer S. Fang, Nan W. Hultgren, Christopher C. W. Hughes, Christopher C. W. Hughes   +3 more
doaj   +1 more source

A new method for the assessment of endothelial function with peripheral arterial volume

BMC Cardiovascular Disorders, 2018
Background Currently, many methodological approaches have been developed to assess peripheral endothelial function. However, a development of the noninvasive and automated technique for routinely assessing endothelial function is still required.
Daoyuan Si, Lujia Ni, Yunfei Wang, Jinsha Liu, Jining Yang, Ping Yang   +5 more
doaj   +1 more source