Results 11 to 20 of about 1,684,780 (315)
Endothelial mechanobiology [PDF]
APL Bioengineering, 2020 Lining the luminal surface of the vasculature, endothelial cells (ECs) are in direct contact with and differentially respond to hemodynamic forces depending on their anatomic location. Pulsatile shear stress (PS) is defined by laminar flow and is predominantly located in straight vascular regions, while disturbed or oscillatory shear stress (OS) is ...
Ming He +4 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 The endothelium plays important roles in modulating vascular tone by synthesizing and releasing a variety of endothelium-derived relaxing factors, including vasodilator prostaglandins, NO, and endothelium-dependent hyperpolarization factors, as well as endothelium-derived contracting factors.
Shigeo, Godo, Hiroaki, Shimokawa
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Cardiovascular Research, 2005 Aging is considered to be the major risk factor for the development of atherosclerosis and, therefore, for coronary artery disease. Apart from age-associated remodeling of the vascular wall, which includes luminal enlargement, intimal and medial thickening, and increased vascular stiffness, endothelial function declines with age.
Ralf P, Brandes +2 more
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Flow-induced reprogramming of endothelial cells in atherosclerosis
Nature Reviews Cardiology, 2023 Atherosclerotic diseases such as myocardial infarction, ischaemic stroke and peripheral artery disease continue to be leading causes of death worldwide despite the success of treatments with cholesterol-lowering drugs and drug-eluting stents, raising the
I. Tamargo +4 more
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Metabolites, 2020 Metabolomic analysis is an emerging new diagnostic tool, which holds great potential for improving the understanding of osteoarthritis (OA)-caused metabolomic shifts associated with systemic inflammation and oxidative stress.
Kaspar Tootsi +5 more
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Pharmacological Reviews, 2021 The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and homeostasis. Endothelial functions in health include dynamic maintenance of vascular tone, angiogenesis, hemostasis, and the ...
Suowen Xu +14 more
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Journal of the American Society of Nephrology, 2004 Endothelial dysfunction is characterized by a shift of the actions of the endothelium toward reduced vasodilation, a proinflammatory state, and prothrombic properties. It is associated with most forms of cardiovascular disease, such as hypertension, coronary artery disease, chronic heart failure, peripheral artery disease, diabetes, and chronic renal ...
Dierk H, Endemann, Ernesto L, Schiffrin
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Endothelial metaplasia in the iridocorneal endothelial syndrome
American Journal of Ophthalmology, 1997 To test the hypothesis that the aberrant, cytokeratin-expressing cells that replace endothelium in the iridocorneal endothelial (ICE) syndrome are of endothelial origin.Corneas from four patients with Chandler's syndrome and three with essential iris atrophy were examined by two-color immunofluorescence for simultaneous expression of cytokeratins and ...
D N, Howell +3 more
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Systemic Inflammation, Endothelial Function, and Risk of Periodontitis in Overweight/Obese Adults
Biomedicines, 2023 The network interaction between systemic inflammatory mediators, endothelial cell adhesion function, and adiponectin as mediators of the association between metabolic diseases and periodontitis has not been evaluated.
Oelisoa M. Andriankaja +6 more
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ROS-triggered endothelial cell death mechanisms: Focus on pyroptosis, parthanatos, and ferroptosis
Frontiers in Immunology, 2022 The endothelium is a single layer of epithelium covering the surface of the vascular system, and it represents a physical barrier between the blood and vessel wall that plays an important role in maintaining intravascular homeostasis.
Dongdong Zheng +5 more
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