Results 11 to 20 of about 6,284,362 (305)
Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells. [PDF]
PLoS ONE, 2012 Cryptococcosis is a life-threatening fungal disease with a high rate of mortality among HIV/AIDS patients across the world. The ability to penetrate the blood-brain barrier (BBB) is central to the pathogenesis of cryptococcosis, but the way in which this
Wilber Sabiiti, Robin C May
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Brain endothelial cells as phagocytes: mechanisms and implications. [PDF]
Fluids Barriers CNSAbstract Brain microvascular endothelial cells (BECs) lining the brain capillaries form the anatomical site of the blood-brain barrier (BBB), providing a highly selective barrier to support brain homeostasis and function. While the BBB acts as a barrier to immune cells and pathogens under normal conditions, BECs can facilitate their entry ...
Chang RT, Fisher MJ, Sumbria RK.
europepmc +5 more sources
Targeting of endothelial cells in brain tumours
Clinical and Translational Medicine, 2023 AbstractBackgroundAggressive brain tumours, whether primary gliomas or secondary metastases, are characterised by hypervascularisation and are fatal. Recent research has emphasised the crucial involvement of endothelial cells (ECs) in all brain tumour genesis and development events, with various patterns and underlying mechanisms identified.Main ...
Wenzhe Duan +5 more
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Apicobasal polarity of brain endothelial cells [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2015 Normal brain homeostasis depends on the integrity of the blood–brain barrier that controls the access of nutrients, humoral factors, and immune cells to the CNS. The blood–brain barrier is composed mainly of brain endothelial cells. Forming the interface between two compartments, they are highly polarized.
Worzfeld, T., Schwaninger, M.
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Bone marrow derived cells as endothelial precursors and the role of multi-potent progenitor cells in repairing ischaemic tissues. [PDF]
, 2007 PhDIntroduction: Atherosclerosis and its complications are a major cause of death and disability and it remains a major challenge to develop new therapies for patients with irreversible end organ damage and ongoing ischaemia.
Wragg, Andrew
core +4 more sources
Frontiers in Cell and Developmental Biology, 2021 Reports of APOE4-associated neurovascular dysfunction during aging and in neurodegenerative disorders has led to ongoing research to identify underlying mechanisms.
Felecia M. Marottoli +8 more
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PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]
, 2007 Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P. +13 more
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Neuregulin-1 Signaling in Brain Endothelial Cells [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2008 Neuregulin-1 (NRG1) signaling has multiple functions in neurons and glia. The data in this study show that NRG1 may also possess significant signaling and cytoprotective properties in human brain microvascular endothelial cells (BMECs).
Josephine, Lok +8 more
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Neural Regeneration Research, 2015 Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression
Qi-jin Yu +3 more
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Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone [PDF]
PeerJ, 2018 The blood–brain barrier (BBB), an interface between the systemic circulation and the nervous system, can be a target of cytokines in inflammatory conditions.
András Harazin +8 more
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