Results 11 to 20 of about 352,771 (231)
Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
Fluids and Barriers of the CNS, 2019 Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge +5 more
doaj +1 more source
Neurobiology of Disease, 2017 Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is a neuroinflammatory, demyelinating disease widely recognized as an animal model of multiple ...
Bandana Shrestha +5 more
doaj +1 more source
Research progress on perioperative blood-brain barrier damage and its potential mechanism
Frontiers in Cell and Developmental Biology, 2023 The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins.
Yong Qiu +13 more
doaj +1 more source
Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
Fluids and Barriers of the CNS, 2018 Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez +3 more
doaj +1 more source
Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
doaj +1 more source
Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective
Frontiers in Pharmacology, 2019 Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie +2 more
doaj +1 more source
, 2017 Additional file 1: Tables S1. ImKTx88 reduces clinical signs in EAE rats.
Huang, Jie +10 more
openaire +1 more source
, 2017 Additional file 1. Additional characterization of iPSC-derived BMECsâ primary antibody and secondary antibody information, including recognized antigen, clone, vendor, and dilution, are listed in Tables S1 and S2, respectively. Immunocytochemical analysis of astrocytes and pericytes used in co-culture experiment are shown in Figure S1.
Hollmann, Emma +5 more
openaire +1 more source
Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V
Molecules, 2015 α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch +7 more
doaj +1 more source
Cannabinoids, Blood–Brain Barrier, and Brain Disposition
Pharmaceutics, 2020 Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai +6 more
doaj +1 more source