Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. [PDF]
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Susanne MA van der Pol +52 more
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PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells [PDF]
Interactions between leukocytes and vascular endothelial cells are mediated by a complex set of membrane adhesion molecules which transduce bi-directional signals in both cell types.
Laran-Chich, M.-P. +13 more
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Ictal lack of binding to brain parenchyma suggests integrity of the blood-brain barrier for 11C-dihydroergotamine during glyceryl trinitrate-induced migraine. [PDF]
SEE DREIER DOI 101093/AWW112 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: For many decades a breakdown of the blood-brain barrier has been postulated to occur in migraine.
Schankin, Christoph +23 more
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Computational design of drugs for Epilepsy using a novel guided evolutionary algorithm for enhanced Blood Brain Barrier permeability [PDF]
Epilepsy is a common disorder of the Central Nervous System. Although several drugs are available for treatment of epilepsy, none of them are applicable for all cases, and some have serious adverse affects. The rational design of small molecule drugs for
Sekhar, Talluri
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Physiology of Blood Brain Barrier
This thesis takes on the theme of blood-brain barrier. Blood-brain barrier is a physiological barrier, that divides the circulatory system from brain, in place of their konfrontation.
Kellner, Patrik
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Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy
Blood–brain barrier dysfunction is implicated in various neurological conditions. Modulating the blood–brain barrier may have therapeutic value. Progress is hindered by our limited understanding of the pathophysiology of the blood–brain barrier in humans,
Martinian, L. +7 more
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Plasma membrane monoamine transporter (PMAT) is a polyspecific organic cation transporter that is highly expressed in the central nervous system. This study aimed to investigate the effect of lipopolysaccharide on PMAT expression at the blood-brain ...
Wu, Kuo-Chen;Lu, Ya-Hsuan;Peng, Yi-Hsuan;Hsu, Lih-Ching;Lin, Chun-Jung +1 more
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Use of the MicroSiM (µSiM) Barrier Tissue Platform for Modeling the Blood-Brain Barrier. [PDF]
The microSiM (µSiM) is a membrane-based culture platform for modeling the blood-brain barrier (BBB). Unlike conventional membrane-based platforms, the µSiM provides experimentalists with new capabilities, including live cell imaging, unhindered paracrine
Trempel, Michelle +8 more
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Blood-brain barrier derangement after electrical brain stimulation [PDF]
Noninvasive brain stimulation methods, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation (tDCS), have received considerable attention in recent years for use in the study and treatment of neurological ...
Nik Abd Rahman, Nik Mohd Afizan +2 more
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Ryszard Pluta, Marzena UtamekLaboratory of Ischemic and Neurodegenerative Brain Research, Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, PolandAbstract: The development of neuronal death and ...
Ryszard Pluta, Poland, Marzena Utamek
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