Results 21 to 30 of about 4,745,742 (154)
'Acanthamoeba' produces disseminated infection in locusts and traverses the locust blood-brain barrier to invade the central nervous system [PDF]
, 2010 BACKGROUND: Many aspects of Acanthamoeba granulomatous encephalitis remain poorly understood, including host susceptibility and chronic colonization which represent important features of the spectrum of host-pathogen interactions.
Mortazavi, Parisa Nakhostin +11 more
core +1 more source
"In vitro" evaluation of blood-brain barrier transport [PDF]
, 2014 The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
core +1 more source
The dynamic blood–brain barrier [PDF]
The FEBS Journal, 2015 With the endothelium as its central unit, the blood–brain barrier (BBB) is a complex multicellular structure separating the central nervous system (CNS) from the systemic circulation. Disruption of the BBB has now been implicated in a multitude of acute and chronic CNS disorders indicating the potentially devastating effects of BBB breakdown on brain ...
James, Keaney, Matthew, Campbell
openaire +2 more sources
Disruption of the blood-brain barrier in 22q11.2 deletion syndrome
, 2021 International audienceNeuroimmune dysregulation is implicated in neuropsychiatric disorders including schizophrenia. As the blood-brain barrier is the immunological interface between the brain and the periphery, we investigated whether this vascular ...
Kebir, Hania +31 more
core +1 more source
Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin b1 receptor agonist in a glioma rat model [PDF]
, 2012 Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of ...
Neugebauer Witold +47 more
core +2 more sources
Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown [PDF]
, 2010 Background: An inducible release of soluble junctional adhesion molecule-A (sJAM-A) under pro-inflammatory conditions was described in cultured non-CNS endothelial cells (EC) and increased sJAM-A serum levels were found to indicate inflammation in non ...
Romero, Ignacio +32 more
core +1 more source
Capsule independent uptake of the fungal pathogen Cryptococcus neoformans into brain microvascular endothelial cells. [PDF]
, 2012 Cryptococcosis is a life-threatening fungal disease with a high rate of mortality among HIV/AIDS patients across the world. The ability to penetrate the blood-brain barrier (BBB) is central to the pathogenesis of cryptococcosis, but the way in which this
May, Robin C +11 more
core +2 more sources
, 2004 The status of the blood-CNS barriers during morphine dependence or withdrawal is still unknown. Morphine-withdrawal is associated with profound stress response, immediate early gene expression in the CNS and alterations in neurochemical metabolism. Thus,
Sharma, Hari Shanker,
core +5 more sources
A breach in the blood-brain barrier [PDF]
Proceedings of the National Academy of Sciences, 2005 A fundamental problem affecting the efficacy of drugs is their ability to be delivered from the site of administration to the site of pathology. Nowhere is this issue a more confounding problem than for protein drugs designed to treat the neuropathology associated with many lysosomal storage diseases (LSDs) where the blood-brain barrier (BBB) stands in
openaire +2 more sources
In vivo approaches to assessing the blood-brain barrier
, 2014 Methods for in vivo assessment of blood-brain barrier (BBB) transport are presented, with their advantages and disadvantages. The methods described are brain uptake index, the i.v.
Hammarlund-Udenaes, Margareta,
core +1 more source