Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
Fluids and Barriers of the CNS, 2018 Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez +3 more
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Transferrin Receptor Mediated Brain Uptake During Ischemia and Reperfusion
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Purpose. Drug delivery by transferrin receptor-mediated transport at the blood-brain barrier has shown beneficial effects in animal models of stroke, but it is unclear whether receptor mediated uptake remains functional in the ischemic tissue.
Jiukuan Hao, Ulrich Bickel
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What is the blood–brain barrier (not)? [PDF]
Trends in Immunology, 2007 In 1900, summarizing his experiments with toxins and Ehrlich's earlier observations with intravital dyes, the Berlin physician Lewandowski concluded that "brain capillaries must hold back certain molecules". Illustrating this phenomenon with persuasive beauty, the subsequently evolving metaphor of a 'Bluthirnschranke' (blood-brain barrier, BBB) gained ...
Ingo, Bechmann +2 more
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"In vitro" evaluation of blood-brain barrier transport [PDF]
, 2014 The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
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The embryonic blood-CSF barrier has molecular elements for specific glucose transport and for the general transport of molecules via transcellular routes. [PDF]
, 2010 In vertebrates, early brain development takes place at the expanded anterior end of the neural tube, which is filled with embryonic cerebrospinal fluid (E-CSF).
Bueno i Torrens, David, 1965- +3 more
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Harmful Effects of Smoking Cannabis: A Cerebrovascular and Neurological Perspective
Frontiers in Pharmacology, 2019 Apart from being used as a medicine, cannabis or marijuana is the most widely abused recreational drug all over the world. The legalization and decriminalization of cannabis in Canada and various states of USA may be the underlying reason of the ...
Sabrina Rahman Archie +2 more
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Accumulation of GD1α Ganglioside in MDA-MB-231 Breast Cancer Cells Expressing ST6GalNAc V
Molecules, 2015 α-Series gangliosides define a particular sub-class of glycosphingolipids containing sialic acid α2,6-linked to GalNAc residue that was isolated as a minor compound from the brain.
Sandy Vandermeersch +7 more
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MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation [PDF]
, 2014 This work was funded by the Multiple Sclerosis Society. Tissue samples and associated clinical and neuropathological data were supplied by the UK MS Tissue ...
Kay, O. +41 more
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Cannabinoids, Blood–Brain Barrier, and Brain Disposition
Pharmaceutics, 2020 Potential therapeutic actions of the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are based on their activity as analgesics, anti-emetics, anti-inflammatory agents, anti-seizure compounds.
Fabrizio Calapai +6 more
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Blood-Brain Barriers in Obesity [PDF]
The AAPS Journal, 2017 After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden.
Elizabeth M, Rhea +5 more
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