Results 11 to 20 of about 792,108 (354)

The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, 2023
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates the pharmacotherapy for CNS disorders as the most chemical drugs and ...
Di Wu, Qi Chen, Xiaojie Chen, Feng Han, Zhong Chen, Yi Wang   +5 more
semanticscholar   +1 more source

Vesicular Trafficking, a Mechanism Controlled by Cascade Activation of Rab Proteins: Focus on Rab27

Biology, 2023
Vesicular trafficking is essential for the cell to internalize useful proteins and soluble substances, for cell signaling or for the degradation of pathogenic elements such as bacteria or viruses.
Camille Menaceur, Océane Dusailly, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol   +4 more
doaj   +1 more source

Highlighting In Vitro the Role of Brain-like Endothelial Cells on the Maturation and Metabolism of Brain Pericytes by SWATH Proteomics

Cells, 2023
Within the neurovascular unit, brain pericytes (BPs) are of major importance for the induction and maintenance of the properties of the blood-brain barrier (BBB) carried by the brain microvessel endothelial cells (ECs).
Camille Menaceur, Johan Hachani, Shiraz Dib, Sophie Duban-Deweer, Yannis Karamanos, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol   +9 more
doaj   +1 more source

Appearance of claudin-5+ leukocyte subtypes in the blood and CNS during progression of EAE

Journal of Neuroinflammation, 2021
Background Tight junctions (TJs) are membrane specializations characteristic of barrier-forming membranes, which function to seal the aqueous pathway between endothelial cells or epithelial cells and, thereby, obstruct intercellular solute and cellular ...
Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison, Joel S. Pachter   +4 more
doaj   +1 more source

RETRACTED ARTICLE: Secretome of endothelial progenitor cells from stroke patients promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage

Stem Cell Research & Therapy, 2021
Background Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term.
Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell, Fabien Gosselet   +14 more
doaj   +1 more source

Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?

Physiological Reports, 2021
Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to be a world‐wide pandemic with overwhelming socioeconomic impact.
Vardan T. Karamyan
doaj   +1 more source

A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

Fluids and Barriers of the CNS, 2020
The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function.
Hossam Kadry, Behnam Noorani, L. Cucullo
semanticscholar   +1 more source

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model

Fluids and Barriers of the CNS, 2019
Background Immune cell trafficking into the CNS is considered to contribute to pathogenesis in MS and its animal model, EAE. Disruption of the blood–brain barrier (BBB) is a hallmark of these pathologies and a potential target of therapeutics.
Shujun Ge, Xi Jiang, Debayon Paul, Li Song, Xiaofang Wang, Joel S. Pachter   +5 more
doaj   +1 more source

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro [PDF]

, 2013
Reproducing the characteristics and the functional responses of the blood–brain barrier (BBB) in vitro represents an important task for the research community, and would be a critical biotechnological breakthrough.
Eleanna Papa (441409), Rudini, Noemi, B. Engelhardt, Papa, Eleanna, E. Papa, M. Corada, Kavi Devraj, Pierre Olivier Couraud (383879), Couraud, Pierre Olivier, Luca Ferrarini, Monica Corada, Roberta Paolinelli, Pierre Olivier Couraud, K. Devraj, Luigi Maddaluno (441408), Cathrin J Czupalla, Engelhardt, Britta, Britta Engelhardt, Stefan Liebner (307398), R. Paolinelli, Noemi Rudini (441407), C. J. Czupalla, Cédric Artus, Luca Ferrarini (441403), E. Dejana, Elisabetta Dejana, C. Artus, Roberta Paolinelli (237864), Ferrarini, Luca, Devraj, Kavi, Dejana, Elisabetta, N. Rudini, Elisabetta Dejana (110746), Paolinelli, Roberta, Liebner, Stefan, Noemi Rudini, Monica Corada (217515), Cathrin J. Czupalla (441406), Kavi Devraj (441404), Artus, Cédric, Luigi Maddaluno, Cédric Artus (441405), Eleanna Papa, P. O. Couraud, Corada, Monica, Czupalla, Cathrin Jacqueline, Stefan Liebner, L. Maddaluno, Czupalla, Cathrin J., S. Liebner, Maddaluno, Luigi, Britta Engelhardt (307404), L. Ferrarini   +52 more
core   +1 more source

Blood–brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders

Nature Reviews Neurology, 2018
The blood–brain barrier (BBB) is a continuous endothelial membrane within brain microvessels that has sealed cell-to-cell contacts and is sheathed by mural vascular cells and perivascular astrocyte end-feet.
Melanie D. Sweeney, A. Sagare, B. Zlokovic   +2 more
semanticscholar   +1 more source