Results 11 to 20 of about 414,704 (315)

Wnt/beta-catenin signaling controls development of the blood–brain barrier [PDF]

, 2008
The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial Wnt/beta-catenin (beta-cat) signaling regulates induction and ...
Fruttiger, Marcus, Hartwig Wolburg, Babbage, J., M. Corada, Taddei, A., Monica Corada, Babbage, Jane, Wolburg, Hartwig, Corada, M., Makoto M. Taketo, Plate, Karl, A. Felici, Wolburg, H., C. J. Czupalla, Karl Heinz Plate, Harald von Melchner, Reis, M., E. Dejana, Gerhardt, Holger, Elisabetta Dejana, Marcus Fruttiger, M. Fruttiger, Dejana, Elisabetta, Angelina Felici, Jane Babbage, Taddei, Andrea, Liebner, S., Taketo, Makoto Mark, Felici, A., Liebner, Stefan, K. H. Plate, Reis, Marco, Bangsow, T., Dejana, E., M. Reis, Marco Reis, Czupalla, C.J., T. Bangsow, Cathrin J. Czupalla, A. Taddei, Felici, Angelina, H. von Melchner, Andrea Taddei, H. Wolburg, Taketo, M.M., von Melchner, H., J. Babbage, H. Gerhardt, Plate, K.H., Corada, Monica, M. M. Taketo, Czupalla, Cathrin Jacqueline, Holger Gerhardt, Stefan Liebner, S. Liebner, Fruttiger, M., Gerhardt, H., Bangsow, Thorsten, Melchner, Harald von (Prof. Dr.), Thorsten Bangsow   +59 more
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What is the blood–brain barrier (not)? [PDF]

Trends in Immunology, 2007
In 1900, summarizing his experiments with toxins and Ehrlich's earlier observations with intravital dyes, the Berlin physician Lewandowski concluded that "brain capillaries must hold back certain molecules". Illustrating this phenomenon with persuasive beauty, the subsequently evolving metaphor of a 'Bluthirnschranke' (blood-brain barrier, BBB) gained ...
Ingo, Bechmann, Ian, Galea, V Hugh, Perry   +2 more
openaire   +2 more sources

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model [PDF]

, 2012
Background: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases.
Tikva Vogel, Zensi, Anja, von Briesen Hagen, Kreuter Jörg, Worek Franz, Tschickardt, Sabrina E., Sascha L Wien, Jörg Kreuter, Wien Sascha L., Vogel Tikva, Sabrina E Tschickardt, Wladislaw Maier, Vogel, Tikva, Sylvia Wagner, Claus U Pietrzik, Maier Wladislaw, Zensi Anja, Wien, Sascha L., Maier, Wladislaw, Tschickardt Sabrina E., Wagner, Sylvia, Pietrzik Claus U., Anja Zensi, Kreuter, Jörg, Worek, Franz, Hagen von Briesen, Pietrzik, Claus Ulrich, Briesen, Hagen von, Wagner Sylvia, Franz Worek   +29 more
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Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro [PDF]

, 2013
Reproducing the characteristics and the functional responses of the blood–brain barrier (BBB) in vitro represents an important task for the research community, and would be a critical biotechnological breakthrough.
Eleanna Papa (441409), Rudini, Noemi, B. Engelhardt, Papa, Eleanna, E. Papa, M. Corada, Kavi Devraj, Pierre Olivier Couraud (383879), Couraud, Pierre Olivier, Luca Ferrarini, Monica Corada, Roberta Paolinelli, Pierre Olivier Couraud, K. Devraj, Luigi Maddaluno (441408), Cathrin J Czupalla, Engelhardt, Britta, Britta Engelhardt, Stefan Liebner (307398), R. Paolinelli, Noemi Rudini (441407), C. J. Czupalla, Cédric Artus, Luca Ferrarini (441403), E. Dejana, Elisabetta Dejana, C. Artus, Roberta Paolinelli (237864), Ferrarini, Luca, Devraj, Kavi, Dejana, Elisabetta, N. Rudini, Elisabetta Dejana (110746), Paolinelli, Roberta, Liebner, Stefan, Noemi Rudini, Monica Corada (217515), Cathrin J. Czupalla (441406), Kavi Devraj (441404), Artus, Cédric, Luigi Maddaluno, Cédric Artus (441405), Eleanna Papa, P. O. Couraud, Corada, Monica, Czupalla, Cathrin Jacqueline, Stefan Liebner, L. Maddaluno, Czupalla, Cathrin J., S. Liebner, Maddaluno, Luigi, Britta Engelhardt (307404), L. Ferrarini   +52 more
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Spatiotemporal resolution of spinal meningeal and parenchymal inflammation during experimental autoimmune encephalomyelitis

Neurobiology of Disease, 2017
Experimental autoimmune encephalomyelitis (EAE) induced by active immunization of C57BL/6 mice with peptide from myelin oligodendrocyte protein (MOG35–55), is a neuroinflammatory, demyelinating disease widely recognized as an animal model of multiple ...
Bandana Shrestha, Xi Jiang, Shujun Ge, Debayon Paul, Peter Chianchiano, Joel S. Pachter   +5 more
doaj   +1 more source

Blood-Brain Barriers in Obesity [PDF]

The AAPS Journal, 2017
After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden.
Elizabeth M, Rhea, Therese S, Salameh, Aric F, Logsdon, Angela J, Hanson, Michelle A, Erickson, William A, Banks   +5 more
openaire   +2 more sources

"In vitro" evaluation of blood-brain barrier transport [PDF]

, 2014
The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
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Blood—Brain Barrier Genomics [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2001
The blood–brain barrier (BBB) is formed by the brain microvascular endothelium, and the unique transport properties of the BBB are derived from tissue-specific gene expression within this cell. The current studies developed a gene microarray approach specific for the BBB by purifying the initial mRNA from isolated rat brain capillaries to generate ...
J Y, Li, R J, Boado, W M, Pardridge
openaire   +2 more sources

The Blood-Brain Barrier in Psychosis [PDF]

, 2018
Blood-brain barrier pathology is recognised as a central factor in the development of many neurological disorders, but much less is known about the role of the blood-brain barrier in psychiatric disorders.
Thomas A Pollak, Svetlana Drndarski, N Joan Abbott, Stone, M.J., McGuire, P., Pollak, T.A., James M Stone, Drndarski, S., Philip McGuire, Abbott, N.J., David, A.S., Anthony S David   +11 more
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Structure and function of the blood–brain barrier

Neurobiology of Disease, 2010
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood–brain barrier (BBB), blood–CSF barrier and the arachnoid barrier.
N. Joan Abbott, Adjanie A.K. Patabendige, Diana E.M. Dolman, Siti R. Yusof, David J. Begley   +4 more
doaj   +1 more source