Results 61 to 70 of about 414,704 (315)

Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]

, 2011
Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller, Thal, Serge C., Zausinger, Stefan, Schöller, Karsten, Nikolaus Plesnila, Serge C. Thal, Stefan Zausinger, Feiler, Sergej, Plesnila, Nikolaus, Sergej Feiler   +9 more
core   +1 more source

Investigation of Lysophospholipids-DHA transport across an in vitro human model of blood brain barrier

Heliyon
Several studies emphasized on the preventive and therapeutic potential of Docosahexaenoic Acid (DHA, 22:6n-3) supplementation in chronic and age-related disorders including neurodegenerative diseases.
Mayssa Hachem, Abdelmoneim H. Ali, Ibrahim Yildiz, Christophe Landry, Fabien Gosselet   +4 more
doaj   +1 more source

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Pharmaceutics, 2020
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier.
Ambre Dauba, Anthony Delalande, Hermes A. S. Kamimura, Allegra Conti, Benoit Larrat, Nicolas Tsapis, Anthony Novell   +6 more
doaj   +1 more source

How anti-brain antibodies access the bran and alter behavior and cognition

Journal of Affective Disorders Reports, 2023
Antibodies can target brain antigens but are not harmful to the host unless they enter brain parenchyma. An adult human or mouse has a blood brain barrier that excludes immunoglobulin from entering brain parenchyma.
Betty Diamond, MD
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The cerebrovascular effects of adrenaline, noradrenaline and dopamine infusions under propofol and isoflurane anaesthesia in sheep [PDF]

, 2002
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsInfusions of catecholamines are frequently administered to patients receiving propofol or isoflurane anaesthesia.
Grant, C., Upton, R., Martinez, A., Myburgh, J.   +3 more
core   +2 more sources

An Induced Pluripotent Stem Cell-Derived Human Blood–Brain Barrier (BBB) Model to Test the Crossing by Adeno-Associated Virus (AAV) Vectors and Antisense Oligonucleotides [PDF]

, 2023
The blood-brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predictive ...
Bowerman, Melissa, Malerba, Alberto, Selvakumaran, Jamuna, Yáñez-Muñoz, Rafael J, Lu-Nguyen, Ngoc, Wood, Matthew J, Ursu, Simona   +6 more
core   +2 more sources

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Pharmaceutics
Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption.
Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N. Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza   +10 more
doaj   +1 more source

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Fluids and Barriers of the CNS, 2018
This review considers efflux of substances from brain parenchyma quantified as values of clearances (CL, stated in µL g−1 min−1). Total clearance of a substance is the sum of clearance values for all available routes including perivascular pathways and ...
Stephen B. Hladky, Margery A. Barrand
doaj   +1 more source

Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors

Frontiers in Oncology, 2020
Recent advances in maximum safe glioma resection have included the introduction of a host of visualization techniques to complement intraoperative white-light imaging of tumors.
Evgenii Belykh, Kurt V. Shaffer, Chaoqun Lin, Vadim A. Byvaltsev, Mark C. Preul, Lukui Chen   +5 more
doaj   +1 more source