Results 71 to 80 of about 792,108 (354)

How anti-brain antibodies access the bran and alter behavior and cognition

Journal of Affective Disorders Reports, 2023
Antibodies can target brain antigens but are not harmful to the host unless they enter brain parenchyma. An adult human or mouse has a blood brain barrier that excludes immunoglobulin from entering brain parenchyma.
Betty Diamond, MD
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease

Brain : a journal of neurology, 2022
Alzheimer’s disease is a neurodegenerative disorder that causes age-dependent neurological and cognitive declines. The treatments for Alzheimer’s disease pose a significant challenge, because the mechanisms of disease are not being fully understood ...
Qi Wang, Xiaomin Huang, Yixun Su, Guowei Yin, Shouyu Wang, Bin Yu, Hui Li, Junhua Qi, Hui Chen, Wen Zeng, Kai Zhang, A. Verkhratsky, Jianqin Niu, Chenju Yi   +13 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin b1 receptor agonist in a glioma rat model

, 2012
Treatment of malignant glioma with chemotherapy is limited mostly because of delivery impediment related to the blood-brain tumor barrier (BTB). B1 receptors (B1R), inducible prototypical G-protein coupled receptors (GPCR) can regulate permeability of ...
Neugebauer Witold, Audrey Fortier, Martin Savard (163526), David Fortin (163586), Tsanaclis Ana-Maria, Céléna Dubuc, Jérôme Côté (163514), Céléna Dubuc (163533), Audrey Fortier (163543), Dubuc Céléna, Gobeil, Fernand, Müller-Esterl Werner, Fortin David, Neugebauer, Witold, Werner Müller-Esterl, Gobeil Fernand, Martin Savard, Fortier, Audrey, Tsanaclis, Ana-Maria, Witold Neugebauer (163552), Fernand Gobeil, Tremblay Luc, Luc Tremblay (163561), Lepage, Martin, Veronica Bovenzi (163520), Müller-Esterl, Werner, Bovenzi Veronica, David Fortin, Jérôme Côté, Ana-Maria Tsanaclis, Martin Lepage (125474), Fernand Gobeil Jr (163594), Savard Martin, Fortier Audrey, Dubuc, Céléna, Tremblay, Luc, Lepage Martin, Côté, Jérôme, Luc Tremblay, Martin Lepage, Ana-Maria Tsanaclis (163574), Bovenzi, Veronica, Savard, Martin, Veronica Bovenzi, Côté Jérôme, Fortin, David, Werner Müller-Esterl (37090), Witold Neugebauer   +47 more
core   +1 more source

Contribution of Matrix Metalloproteinase-9 to Cerebral Edema and Functional Outcome following Experimental Subarachnoid Hemorrhage [PDF]

, 2011
Background: Cerebral edema is an important risk factor for death and poor outcome following subarachnoid hemorrhage (SAH). However, underlying mechanisms are still poorly understood.
Karsten Schöller, Thal, Serge C., Zausinger, Stefan, Schöller, Karsten, Nikolaus Plesnila, Serge C. Thal, Stefan Zausinger, Feiler, Sergej, Plesnila, Nikolaus, Sergej Feiler   +9 more
core   +1 more source

Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment

Nature Neuroscience
Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19) pathogenesis and may predispose to the neurological sequelae associated with long COVID, yet it is unclear how blood–brain barrier (BBB) function is affected in these ...
C. Greene, Ruairi Connolly, Declan Brennan, A. Laffan, Eoin O’Keeffe, Lilia Zaporojan, Jeffrey O’Callaghan, Bennett Thomson, Emma Connolly, Ruth Argue, James F. M. Meaney, I. Martín-Loeches, A. Long, C. N. Cheallaigh, N. Conlon, Colin P. Doherty, Matthew Campbell   +16 more
semanticscholar   +1 more source

The blood-brain barrier in systemic inflammation.

Brain, behavior, and immunity, 2017
The blood-brain barrier (BBB) plays a key role in maintaining the specialized microenvironment of the central nervous system (CNS), and enabling communication with the systemic compartment. BBB changes occur in several CNS pathologies.
A. Varatharaj, Ian Galea
semanticscholar   +1 more source

Investigation of Lysophospholipids-DHA transport across an in vitro human model of blood brain barrier

Heliyon
Several studies emphasized on the preventive and therapeutic potential of Docosahexaenoic Acid (DHA, 22:6n-3) supplementation in chronic and age-related disorders including neurodegenerative diseases.
Mayssa Hachem, Abdelmoneim H. Ali, Ibrahim Yildiz, Christophe Landry, Fabien Gosselet   +4 more
doaj   +1 more source

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Pharmaceutics, 2020
The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery. Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to disrupt the blood-brain barrier.
Ambre Dauba, Anthony Delalande, Hermes A. S. Kamimura, Allegra Conti, Benoit Larrat, Nicolas Tsapis, Anthony Novell   +6 more
doaj   +1 more source