Results 81 to 90 of about 792,108 (354)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Adipokines and the blood-brain barrier [PDF]

Peptides, 2007
Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interact with the BBB and exert potent CNS
Weihong, Pan, Abba J, Kastin
openaire   +2 more sources

Functionalized Nanomaterials Capable of Crossing the Blood–Brain Barrier

ACS Nano
The blood–brain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels.
Shuai Zha, Haitao Liu, Hengde Li, Haolan Li, Ka-Leung Wong, A. All   +5 more
semanticscholar   +1 more source

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

Nature Communications, 2019
Microglia survey brain parenchyma, responding to injury and infections. Microglia also respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this process remains unclear.
Koichiro Haruwaka, Ako Ikegami, Y. Tachibana, N. Ohno, Hiroyuki Konishi, Akari Hashimoto, Mami Matsumoto, D. Kato, Riho Ono, H. Kiyama, A. Moorhouse, J. Nabekura, H. Wake   +12 more
semanticscholar   +1 more source

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Pharmaceutics
Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption.
Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N. Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza   +10 more
doaj   +1 more source

Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier

Fluids and Barriers of the CNS, 2018
This review considers efflux of substances from brain parenchyma quantified as values of clearances (CL, stated in µL g−1 min−1). Total clearance of a substance is the sum of clearance values for all available routes including perivascular pathways and ...
Stephen B. Hladky, Margery A. Barrand
doaj   +1 more source

Blood-Brain Barrier, Blood-Brain Tumor Barrier, and Fluorescence-Guided Neurosurgical Oncology: Delivering Optical Labels to Brain Tumors

Frontiers in Oncology, 2020
Recent advances in maximum safe glioma resection have included the introduction of a host of visualization techniques to complement intraoperative white-light imaging of tumors.
Evgenii Belykh, Kurt V. Shaffer, Chaoqun Lin, Vadim A. Byvaltsev, Mark C. Preul, Lukui Chen   +5 more
doaj   +1 more source

The blood brain barrier and Lina Solomonovna Stern (Shtern)

Advances in Clinical Neuroscience & Rehabilitation, 2022
The blood–brain barrier (BBB) regulates the transport of molecules between the central nervous system (CNS) and blood. It consists of two components: the vascular endothelial cells forming so–called tight junctions, and the blood–cerebrospinal fluid ...
JMS Pearce
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cortical organotypic slice cultures as a tool to analyze the neurovascular unit in hypoxia/ischemia and hypothermia-induced neuroprotection [PDF]

, 2013
Neurons and glial cells of the central nervous system (CNS) communicate and work together to function and execute an array of complex tasks. In addition to them a third cell type which also works to keep the brain alive are the cerebral endothelial cells
Chip, Sophorn
core   +1 more source