Results 31 to 40 of about 632,604 (307)

The Y-box factor ZONAB/DbpA associates with GEF-H1/Lfc and mediates Rho-stimulated transcription [PDF]

, 2009
Epithelial tight junctions recruit different types of signalling proteins that regulate cell proliferation and differentiation. Little is known about how such proteins interact functionally and biochemically with each other.
Leefa Chong San, I.V., Isabelle V Leefa Chong San, Maria S Balda, Saima Aijaz, Karl Matter, Nie, M., Aijaz, S., Mei Nie, Balda, M.S., Matter, K.   +9 more
core   +1 more source

Claudin-2-dependent paracellular channels are dynamically gated

eLife, 2015
Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels has never been measured.
Christopher R Weber, Guo Hua Liang, Yitang Wang, Sudipto Das, Le Shen, Alan S L Yu, Deborah J Nelson, Jerrold R Turner   +7 more
doaj   +1 more source

Tight junction protein ZO-1 in Kawasaki disease

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +1 more source

Dbl3 drives Cdc42 signaling at the apical margin to regulate junction position and apical differentiation [PDF]

, 2013
Epithelial cells develop morphologically characteristic apical domains that are bordered by tight junctions, the apical–lateral border. Cdc42 and its effector complex Par6–atypical protein kinase c (aPKC) regulate multiple steps during epithelial ...
Zihni, C., Keep, Nicholas H., Harris, J., Munro, P.M.G., Balda, M.S., Matter, K., Elbediwy, A., Terry, S.J.   +7 more
core   +3 more sources

HSP105 inhibition downregulates store-operated calcium entry and promotes acute UVB-induced tight junction disruption.

PLoS ONE
BackgroundTight junction abnormalities are a common feature of inflammatory skin diseases such as psoriasis and atopic dermatitis and contribute to systemic immune responses.
Kaiyi Zhou, Siyu Luo, Qinxiao Wang, Qian Ye, Sheng Fang   +4 more
doaj   +1 more source

Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability

Biology Open, 2016
Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse reaction of the heart in response to certain drugs. Current in vitro approaches to assess cardiotoxicity have focused on analysing cardiomyocytes.
Emma L. Wilkinson, James E. Sidaway, Michael J. Cross   +2 more
doaj   +1 more source

Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes

Membranes, 2022
The epithelial barrier is crucial for proper gastrointestinal function, preventing the unwanted passage of solutes and therefore representing a prerequisite for vectorial transport.
Laura Stein, Nora Brunner, Salah Amasheh
doaj   +1 more source

Paracellular Ion Channel at the Tight Junction [PDF]

, 2003
The tight junction of epithelial cells excludes macromolecules but allows permeation of ions. However, it is not clear whether this ion-conducting property is mediated by aqueous pores or by ion channels. To investigate the permeability properties of the
Tang, Vivian W., Goodenough, Daniel A.
core   +1 more source

Coffea arabica pulp aqueous extract exhibits the anti-colitogenic effect in mice: preventive efficacy and possible mechanisms of action

Biological Research
Inflammatory bowel disease (IBD) is a chronic inflammatory disease caused mainly by immune overactivation and intestinal mucosal barrier disruption. Coffea arabica pulp aqueous extract (CPE) contains a number of bioactive phenolic compounds that exhibit ...
Apiwan Arinno, Pichayapa Sukmak, Supisara Treveeravoot, Purit Kulworasreth, Pitsinee Supapol, Withsakorn Sangsuwan, Natnicha Teansuk, Wanapas Wachiradejkul, Jakkapong Inchai, Thaniya Sricharunrat, Kanthida Jangyubol, Patthadon Sanghong, Chutima S. Vaddhanaphuti, Chanat Aonbangkhen, Pawin Pongkorpsakol   +14 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source