Results 31 to 40 of about 301,934 (303)

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources

Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling

Current Research in Pharmacology and Drug Discovery
Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-β/AMPK/SIRT-1/ERK-dependent mechanisms ...
Apiwan Arinno, Pichayapa Sukmak, Purisha Kulworasreth, Thaniya Sricharunrat, Chutima S. Vaddhanaphuti, Pawin Pongkorpsakol   +5 more
doaj   +1 more source

Claudin-2-dependent paracellular channels are dynamically gated

eLife, 2015
Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels has never been measured.
Christopher R Weber, Guo Hua Liang, Yitang Wang, Sudipto Das, Le Shen, Alan S L Yu, Deborah J Nelson, Jerrold R Turner   +7 more
doaj   +1 more source

Tight junction protein ZO-1 in Kawasaki disease

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +1 more source

HSP105 inhibition downregulates store-operated calcium entry and promotes acute UVB-induced tight junction disruption.

PLoS ONE
BackgroundTight junction abnormalities are a common feature of inflammatory skin diseases such as psoriasis and atopic dermatitis and contribute to systemic immune responses.
Kaiyi Zhou, Siyu Luo, Qinxiao Wang, Qian Ye, Sheng Fang   +4 more
doaj   +1 more source

Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability

Biology Open, 2016
Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse reaction of the heart in response to certain drugs. Current in vitro approaches to assess cardiotoxicity have focused on analysing cardiomyocytes.
Emma L. Wilkinson, James E. Sidaway, Michael J. Cross   +2 more
doaj   +1 more source

Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes

Membranes, 2022
The epithelial barrier is crucial for proper gastrointestinal function, preventing the unwanted passage of solutes and therefore representing a prerequisite for vectorial transport.
Laura Stein, Nora Brunner, Salah Amasheh
doaj   +1 more source

Backward diode composed of a metallic and semiconducting nanotube

, 2001
The conditions necessary for a nanotube junction connecting a metallic and semiconducting nanotube to rectify the current are theoretically investigated.
A. Bachtold, A.A. Farajian, A.A. Odintsov, B.I. Dunlap, D. Orlikowski, F. Leonard, H. Matsumura, J. Ma, J. Taylor, J.C. Charlier, J.W. Mintmire, K. Harigaya, L. Chico, L. Chico, M.P. Anantram, M.S. Ferreira, N. Hamada, R. Saito, R. Saito, R. Tamura, R. Tamura, R. Tamura, R. Tamura, R.D. Antonov, Ryo Tamura, S. Iijima, S. Iijima, S. Sanvito, S.J. Tans, S.J. Tans, V. Meunier, X. Blase, Z. Yao   +32 more
core   +1 more source

The kidney tight junction [PDF]

, 2014
The tight junction is an important subcellular organelle which plays a vital role in epithelial barrier function. Claudin, as the integral membrane component of tight junctions, creates a paracellular transport pathway for various ions to be reabsorbed ...
Hou, Jianghui
core   +2 more sources

Tight junctions: Closing in on the seal [PDF]

Current Biology, 1999
The claudins have recently been identified as a large family of transmembrane proteins located at tight junctions between epithelial cells; they create the paracellular diffusion barrier and, surprisingly, may also confer channel-like selectivity for passage of solutes through the tissue barrier.
Anderson, James Melvin, Van Itallie, Christina M.   +1 more
openaire   +2 more sources