Results 21 to 30 of about 130,820 (264)

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

BMC Microbiology, 2010
Background Intestinal barrier function is important for preserving health, as a compromised barrier allows antigen entry and can induce inflammatory diseases.
McCann Mark J, Park Zaneta, McNabb Warren C, Cookson Adrian L, Anderson Rachel C, Kelly William J, Roy Nicole C   +6 more
doaj   +1 more source

The ACE2 Receptor for Coronavirus Entry Is Localized at Apical Cell—Cell Junctions of Epithelial Cells

Cells, 2022
Transmembrane proteins of adherens and tight junctions are known targets for viruses and bacterial toxins. The coronavirus receptor ACE2 has been localized at the apical surface of epithelial cells, but it is not clear whether ACE2 is localized at apical
Florian Rouaud, Isabelle Méan, Sandra Citi   +2 more
doaj   +1 more source

Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability in vivo and its related intracellular signaling

Current Research in Pharmacology and Drug Discovery
Intestinal tight junction disruption contributes to the pathogenesis of inflammatory bowel diseases (IBD). We have recently reported that gallic acid was able to enhance intestinal tight junction assembly via CaMKK-β/AMPK/SIRT-1/ERK-dependent mechanisms ...
Apiwan Arinno, Pichayapa Sukmak, Purisha Kulworasreth, Thaniya Sricharunrat, Chutima S. Vaddhanaphuti, Pawin Pongkorpsakol   +5 more
doaj   +1 more source

Claudin-2-dependent paracellular channels are dynamically gated

eLife, 2015
Intercellular tight junctions form selectively permeable barriers that seal the paracellular space. Trans-tight junction flux has been measured across large epithelial surfaces, but conductance across individual channels has never been measured.
Christopher R Weber, Guo Hua Liang, Yitang Wang, Sudipto Das, Le Shen, Alan S L Yu, Deborah J Nelson, Jerrold R Turner   +7 more
doaj   +1 more source

Tight junction protein ZO-1 in Kawasaki disease

BMC Pediatrics, 2021
Background Kawasaki disease (KD) is a form of systemic febrile vasculitis that is complicated with coronary artery lesions (CAL). The tight junctions that maintain the intestinal barrier also play a role in systemic inflammatory diseases.
Wan-Tz Lai, Hung-Chang Lee, Ying-Hsien Huang, Mao-Hung Lo, Ho-Chang Kuo   +4 more
doaj   +1 more source

HSP105 inhibition downregulates store-operated calcium entry and promotes acute UVB-induced tight junction disruption.

PLoS ONE
BackgroundTight junction abnormalities are a common feature of inflammatory skin diseases such as psoriasis and atopic dermatitis and contribute to systemic immune responses.
Kaiyi Zhou, Siyu Luo, Qinxiao Wang, Qian Ye, Sheng Fang   +4 more
doaj   +1 more source

Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability

Biology Open, 2016
Cardiotoxicity induced by anti-cancer therapeutics is a severe, and potentially fatal, adverse reaction of the heart in response to certain drugs. Current in vitro approaches to assess cardiotoxicity have focused on analysing cardiomyocytes.
Emma L. Wilkinson, James E. Sidaway, Michael J. Cross   +2 more
doaj   +1 more source

Tight junctions: Closing in on the seal [PDF]

Current Biology, 1999
The claudins have recently been identified as a large family of transmembrane proteins located at tight junctions between epithelial cells; they create the paracellular diffusion barrier and, surprisingly, may also confer channel-like selectivity for passage of solutes through the tissue barrier.
Anderson, James Melvin, Van Itallie, Christina M.   +1 more
openaire   +2 more sources

Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes

Membranes, 2022
The epithelial barrier is crucial for proper gastrointestinal function, preventing the unwanted passage of solutes and therefore representing a prerequisite for vectorial transport.
Laura Stein, Nora Brunner, Salah Amasheh
doaj   +1 more source

Tight Junctions in Cell Proliferation [PDF]

International Journal of Molecular Sciences, 2019
Tight junction (TJ) proteins form a continuous intercellular network creating a barrier with selective regulation of water, ion, and solutes across endothelial, epithelial, and glial tissues. TJ proteins include the claudin family that confers barrier properties, members of the MARVEL family that contribute to barrier regulation, and JAM molecules ...
Mónica Díaz-Coránguez, Xuwen Liu, David A. Antonetti   +2 more
openaire   +2 more sources