Results 11 to 20 of about 632,604 (307)

Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/NLRP3 Inflammasome Pathway

Toxics, 2022
Inflammation leads to porcine tight junction disruption of small intestinal epithelial cells, resulting in intestinal dysfunction. Herein, we established lipopolysaccharide (LPS)-induced in-vivo and in-vitro inflammatory models. The results revealed that
Jian Kang, Yanhong Zhou, Chunyang Zhu, Tian Ren, Yong Zhang, Longfei Xiao, Binghu Fang   +6 more
doaj   +1 more source

Tight junctions at a glance [PDF]

Journal of Cell Science, 2008
Tight junctions (TJs) are morphologically distinct and highly regulated areas of close contact between the plasma membranes of neighbouring epithelial and endothelial cells. They are the most apical component of the epithelial junctional complex (which also includes adherens junctions and ...
Maria S, Balda, Karl, Matter
openaire   +2 more sources

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Frontiers in Physiology, 2020
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation.
Jeffrey J. Lochhead, Junzhi Yang, Patrick T. Ronaldson, Thomas P. Davis   +3 more
doaj   +1 more source

20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3

Neurobiology of Disease, 2023
Cerebral cavernous malformation type-3 (CCM3) is a type of brain vascular malformation caused by mutations in programmed cell death protein-10 (PDCD10).
Chelsea M. Phillips, Allison M. Johnson, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic   +4 more
doaj   +1 more source

Regulation of tight junction assembly and epithelial morphogenesis by the heat shock protein Apg-2 [PDF]

, 2007
Background: Tight junctions are required for epithelial barrier formation and participate in the regulation of signalling mechanisms that control proliferation and differentiation.
Aijaz Saima, Sanchez-Heras Elena, Balda, MS, Matter Karl, Matter, K, Balda Maria S, Sanchez-Heras, E, Aijaz, S   +7 more
core   +1 more source

STAT3 pathway is involved in interleukin-22 promoting expression of tight junction protein in human colorectal cancer cell line HT29 [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the effect of interleukin-22(IL-22) on intestinal epithelial barrier tight junction and its mechanism. Methods Human colon cancer HT29 cells were divided into control group, IL-22 group(100 ng/mL), FLLL32 group(pretreatment ...
SONG Qian, HUANG Xue, QIN Meng-bin, ZHANG Jun-hong, JING Jie, LUO Yi-hua, LI Yu-xin
doaj  

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family [PDF]

, 2009
Background: Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge.
Rodrigues, N.T.L., Maria S Balda, Nelio TL Rodrigues, Matter Karl, Balda Maria S, Karl Matter, Steed, E., Balda, M.S., Matter, K., Steed Emily, Rodrigues Nelio TL, Emily Steed   +11 more
core   +1 more source

Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo [PDF]

, 2004
We have investigated the contribution of the tight junction (TJ) transmembrane protein junction-adhesion-molecule 1 (JAM-1) to trophectoderm epithelial differentiation in the mouse embryo.
Fay C. Thomas, Dejana, E., Bhavwanti Sheth, Tom P. Fleming, Fleming, T.P., Sheth, B., Judith J. Eckert, Gianfranco Bazzoni, Elisabetta Dejana, Bazzoni, G., Thomas, F.C., Eckert, J.J.   +11 more
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Astrocytes and pericytes attenuate severely injured patient plasma mediated expression of tight junction proteins in endothelial cells.

PLoS ONE, 2022
Blood Brain Barrier (BBB) breakdown is a secondary form of brain injury which has yet to be fully elucidated mechanistically. Existing research suggests that breakdown of tight junction proteins between endothelial cells is a primary driver of increased ...
Preston Stafford, Sanchayita Mitra, Margot Debot, Patrick Lutz, Arthur Stem, Jamie Hadley, Patrick Hom, Terry R Schaid, Mitchell J Cohen   +8 more
doaj   +1 more source

ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions

Cells, 2022
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how tight ...
Alexis J. Haas, Ceniz Zihni, Susanne M. Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria S. Balda, Karl Matter   +8 more
doaj   +1 more source