Results 11 to 20 of about 130,820 (264)
Renal Failure, 2017 Tight junction plays important roles in regulating paracellular transports and maintaining cell polarity. Calcium oxalate monohydrate (COM) crystals, the major crystalline composition of kidney stones, have been demonstrated to be able to cause tight ...
Lei Yu, Xiuguo Gan, Xukun Liu, Ruihua An
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Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. [PDF]
PLoS ONE, 2017 The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space.
Hui Yan, Kolapo M Ajuwon
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Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components
Frontiers in Physiology, 2018 Tight junctions seal off physical barriers, regulate fluid and solute flow, and protect the endoneurial microenvironment of the peripheral nervous system. Physical barriers in the peripheral nervous system were disrupted after nerve injury.
Xinghui Wang +8 more
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Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. [PDF]
PLoS ONE, 2015 Tight junctions are complex membrane structures that regulate paracellular movement of material across epithelia and play a role in cell polarity, signaling and cytoskeletal organization.
Karin Fredriksson +5 more
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Cell Reports, 2017 Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz +7 more
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Structural dynamics of tight junctions modulate the properties of the epithelial barrier.
PLoS ONE, 2019 Tight junctions are dynamic structures that are crucial in establishing the diffusion and electrical barrier of epithelial monolayers. Dysfunctions in the tight junctions can impede this barrier function and lead to many pathological conditions ...
Aapo Tervonen +3 more
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The mechanobiology of tight junctions [PDF]
Biophysical Reviews, 2019 Tight junctions (TJ) play a central role in the homeostasis of epithelial and endothelial tissues, by providing a semipermeable barrier to ions and solutes, by contributing to the maintenance of cell polarity, and by functioning as signaling platforms.
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Molecules, 2023 Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and promotes inflammatory responses.
Vishnu Raj +7 more
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Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. [PDF]
PLoS ONE, 2017 SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types.
Karin Fredriksson-Lidman +3 more
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Journal of Inflammation Research, 2021 Dong Zhang,1 Jin-tao Zhang,1 Yun Pan,1 Xiao-fei Liu,1 Jia-wei Xu,2 Wen-jing Cui,1 Xin-rui Qiao,1 Liang Dong1,2 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China ...
Zhang D +7 more
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