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Oral Mucosal Epithelial Cells [PDF]

Frontiers in Immunology, 2019
Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the organism from chemical, microbial, and physical challenges which is indispensable for viability.
Sabine Groeger, Joerg Meyle
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Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative Processes

Cells, 2021
The gastrointestinal tract is a continuous series of organs from the mouth to the esophagus, stomach, intestine and anus that allows digestion to occur.
Alexane Ollivier, Maxime M. Mahe, Géraldine Guasch   +2 more
doaj   +1 more source

A stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration

Nature Communications, 2021
Transition zones connect distinct epithelia, contain cells expressing stem cell markers, and contribute to cancer development. Here, the authors examine the mouse anorectal junction, identifying a population of Krt17-positive basal cells that contribute ...
Louciné Mitoyan, Véronique Chevrier, Hector Hernandez-Vargas, Alexane Ollivier, Zeinab Homayed, Julie Pannequin, Flora Poizat, Cécile De Biasi-Cador, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Géraldine Guasch   +10 more
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Production of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors

STAR Protocols, 2023
Summary: Primary human mammary epithelial cells (pHMECs) are known to be remarkably difficult to engineer genetically. Here, we present a protocol for efficient transduction of pHMECs using a baboon retroviral envelope glycoprotein for pseudotyping of ...
Sonia Pastor, Julien Wicinski, Emmanuelle Charafe-Jauffret, Els Verhoeyen, Geoffrey Guittard, Christophe Ginestier   +5 more
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BMI1 nuclear location is critical for RAD51-dependent response to replication stress and drives chemoresistance in breast cancer stem cells

Cell Death and Disease, 2022
Replication stress (RS) has a pivotal role in tumor initiation, progression, or therapeutic resistance. In this study, we depicted the mechanism of breast cancer stem cells’ (bCSCs) response to RS and its clinical implication.
Violette Azzoni, Julien Wicinski, Manon Macario, Martin Castagné, Pascal Finetti, Katerina Ambrosova, Célia D. Rouault, Arnaud Sergé, Anne Farina, Emilie Agavnian, Sergiu Coslet, Emmanuelle Josselin, Arnaud Guille, José Adelaide, Emmanouil Zacharioudakis, Rémy Castellano, Francois Bertucci, Daniel Birnbaum, Raphael Rodriguez, Emmanuelle Charafe-Jauffret, Christophe Ginestier   +20 more
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Experimental and spontaneous metastasis assays can result in divergence in clonal architecture

Communications Biology, 2023
Intratumoural heterogeneity is associated with poor outcomes in breast cancer. To understand how malignant clones survive and grow in metastatic niches, in vivo models using cell lines and patient-derived xenografts (PDX) have become the gold standard ...
Antonin Serrano, Tom Weber, Jean Berthelet, Farrah El-Saafin, Sreeja Gadipally, Emmanuelle Charafe-Jauffret, Christophe Ginestier, John M. Mariadason, Samantha R. Oakes, Kara Britt, Shalin H. Naik, Delphine Merino   +11 more
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From Submerged Cultures to 3D Cell Culture Models: Evolution of Nasal Epithelial Cells in Asthma Research and Virus Infection

Viruses, 2021
Understanding the response to viral infection in the context of respiratory diseases is of significant importance. Recently, there has been more focus on the role of the nasal epithelium in disease modeling.
Malik Aydin, Ella A. Naumova, Aliyah Bellm, Ann-Kathrin Behrendt, Federica Giachero, Nora Bahlmann, Wenli Zhang, Stefan Wirth, Friedrich Paulsen, Wolfgang H. Arnold, Anja Ehrhardt   +10 more
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Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker

iScience, 2023
Summary: The conjunctival epithelium consists of conjunctival epithelial cells and goblet cells derived from conjunctival epithelial stem/progenitor cells.
Masahiro Kitao, Ryuhei Hayashi, Kimihito Nomi, Reiko Kobayashi, Tomohiko Katayama, Hiroshi Takayanagi, Akiko Oguchi, Yasuhiro Murakawa, Kohji Nishida   +8 more
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IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells. [PDF]

PLoS ONE, 2018
Alveolar epithelial cells are critical to the pathogenesis of pulmonary inflammation and fibrosis, which are associated with overexpression of type 2 cytokine IL-13.
Yoko Ito, Reem Al Mubarak, Nicole Roberts, Kelly Correll, William Janssen, James Finigan, Rangnath Mishra, Hong Wei Chu   +7 more
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Nasal epithelial cells can act as a physiological surrogate for paediatric asthma studies. [PDF]

PLoS ONE, 2014
INTRODUCTION: Differentiated paediatric epithelial cells can be used to study the role of epithelial cells in asthma. Nasal epithelial cells are easier to obtain and may act as a surrogate for bronchial epithelium in asthma studies.
Surendran Thavagnanam, Jeremy C Parker, Michael E McBrien, Grzegorz Skibinski, Michael D Shields, Liam G Heaney   +5 more
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