Results 31 to 40 of about 5,847,660 (310)

Injury and inflammation promote cancer progression at the anorectal junction

Cell Reports
Summary: In anorectal cancer, epithelial tumors frequently develop in transition zones (TZs) between the anal and the rectal epithelia, a region subjected to inflammation and wounds.
Chloé Petitpas, Louciné Mitoyan, Valentin Thevin, Marjorie Martin, Hector Hernandez-Vargas, Véronique Chevrier, Alexane Ollivier, Muge Kaya, Flora Poizat, Marie Heinisch, Magda Rodrigues, Laetitia Gameiro-Ferreira, Jean-Philippe Ratone, Fabrice Caillol, Yanis Dahel, Solène Hoibian, Marc Giovannini, Cécile de Chaisemartin, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Julien C. Marie, Géraldine Guasch   +21 more
doaj   +1 more source

Lens epithelial cells-induced pluripotent stem cells as a model to study epithelial-mesenchymal transition during posterior capsular opacification

Biochemistry and Biophysics Reports, 2019
The overall goal was to generate an epithelial-mesenchymal transition (EMT) model using lens epithelial cells-induced pluripotent stem cells to elucidate EMT-regulatory factors during posterior capsular opacification (PCO).
Roy Joseph, Katie Bales, Kiran Srivastava, Om Srivastava   +3 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Transforming growth factor-β signaling in thymic epithelial cells : its role in development, steady-state and immune reconstitution [PDF]

, 2010
The thymus constitutes the primary lymphoid organ responsible for the generation of naïve T cells. Its stromal compartment is composed of a scaffold of different subsets of epithelial cells that provide soluble and membrane-bound molecules essential for ...
Hauri-Hohl, Mathias Martin
core   +1 more source

The interplay of DNA damage, epigenetics and tumour heterogeneity in driving cancer cell fitness

Nature Communications
Intra-tumor heterogeneity is a primary cause of therapeutic failure, driving tumor progression. Within tumors, diverse cell states coexist, maintained by a specific chromatin landscape that influences various cell functions, including cancer stemness ...
Celia D. Rouault, Emmanuelle Charafe-Jauffret, Christophe Ginestier   +2 more
doaj   +1 more source

Research progress in the roles of airway epithelial cells in the pathogenesis of asthma

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Asthma is a common chronic respiratory disease, and as a heterogeneous disease, it is driven by a combination of immune, genetic, and environmental factors and involves multiple cells.
XU Yinglian, TIAN Jing, ZHANG Xiang, ZHAO Shunying   +3 more
doaj   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway [PDF]

, 1992
Gene-based therapies for a variety of inherited and acquired pulmonary diseases will require the development of vectors capable of safe and efficient transfer of DNA to the respiratory epithelium.
Boucher, R. C., Rømer, Maria Unni, Boucher, Richard C., Wagner, E., Wagner, Ernst, Birnstiel, Max L., Rømer, M. U., Cotten, Matt, Cotten, M., Agarwal, Santosh, Birnstiel, M. L., Curiel, David T., Agarwal, S., Romer, M., Curiel, D. T.   +14 more
core   +1 more source

The role and mechanisms of gingival epithelial cells in maintaining periodontal homeostasis [PDF]

口腔疾病防治
Periodontal homeostasis is regulated by the complex interplay between the gingival epithelial barrier, the extracellular matrix of soft tissues, the bone coupling system, and immune responses within the periodontal region.
WANG Xiao, WU Yajie, SU Zhifei, LI Jiyao
doaj   +1 more source