Results 51 to 60 of about 1,959,501 (356)

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip [PDF]

, 2015
The intestinal epithelium is a critical component of the gut barrier. Composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, this delicate structure prevents the transfer of harmful microorganisms, antigens ...
A. J. M. Watson, B. J. Campbell, Beaulieu JF, Brown CC, C. A. Duckworth, Casellas F, D. M. Pritchard, Gelberg HB, J. M. Williams, Kaur P, Lee JS, Lobo SM, M. D. Burkitt, Mayhew TM, Moore R, Peschon JJ   +15 more
core   +4 more sources

Injury and inflammation promote cancer progression at the anorectal junction

Cell Reports
Summary: In anorectal cancer, epithelial tumors frequently develop in transition zones (TZs) between the anal and the rectal epithelia, a region subjected to inflammation and wounds.
Chloé Petitpas, Louciné Mitoyan, Valentin Thevin, Marjorie Martin, Hector Hernandez-Vargas, Véronique Chevrier, Alexane Ollivier, Muge Kaya, Flora Poizat, Marie Heinisch, Magda Rodrigues, Laetitia Gameiro-Ferreira, Jean-Philippe Ratone, Fabrice Caillol, Yanis Dahel, Solène Hoibian, Marc Giovannini, Cécile de Chaisemartin, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Julien C. Marie, Géraldine Guasch   +21 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The interplay of DNA damage, epigenetics and tumour heterogeneity in driving cancer cell fitness

Nature Communications
Intra-tumor heterogeneity is a primary cause of therapeutic failure, driving tumor progression. Within tumors, diverse cell states coexist, maintained by a specific chromatin landscape that influences various cell functions, including cancer stemness ...
Celia D. Rouault, Emmanuelle Charafe-Jauffret, Christophe Ginestier   +2 more
doaj   +1 more source

The role and mechanisms of gingival epithelial cells in maintaining periodontal homeostasis [PDF]

口腔疾病防治
Periodontal homeostasis is regulated by the complex interplay between the gingival epithelial barrier, the extracellular matrix of soft tissues, the bone coupling system, and immune responses within the periodontal region.
WANG Xiao, WU Yajie, SU Zhifei, LI Jiyao
doaj   +1 more source

Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study. [PDF]

PLoS ONE, 2013
Nasopharyngeal carcinoma (NPC) is common among southern Chinese including the ethnic Cantonese population living in Hong Kong. Epstein-Barr virus (EBV) infection is detected in all undifferentiated type of NPC in this endemic region.
Yim Ling Yip, Pei Shin Pang, Wen Deng, Chi Man Tsang, Musheng Zeng, Pok Man Hau, Cornelia Man, Yuesheng Jin, Anthony Po Wing Yuen, Sai Wah Tsao   +9 more
doaj   +1 more source

Scutoids are a geometrical solution to three-dimensional packing of epithelia [PDF]

, 2018
As animals develop, tissue bending contributes to shape the organs into complex three-dimensional structures. However, the architecture and packing of curved epithelia remains largely unknown. Here we show by means of mathematical modelling that cells in
Bermúdez Gallardo, Marina, Castro Rodríguez, Ana María, Escudero Cuadrado, Luis María, Forja Barbosa, Cristina, Grima Ruiz, Clara Isabel, Gómez Gálvez, Pedro, Letrán, Marta, Márquez Pérez, Alberto, Serrano Pérez-Higueras, Óscar, Tagua Jáñez, Antonio, Vicente Munuera, Pablo   +10 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Calu-3 epithelial cells exhibit different immune and epithelial barrier responses from freshly isolated primary nasal epithelial cells in vitro

Clinical and Translational Allergy, 2018
Epithelial cell lines are often used to evaluate the effect of exogenous/endogenous stimuli on epithelial barrier function and innate immune responses in allergic airway diseases, without clear view on differences between epithelial cell lines and ...
Katleen Martens, Peter W. Hellings, Brecht Steelant   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source