Results 71 to 80 of about 5,847,660 (310)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Biological effects of cigarette smoke in cultured human retinal pigment epithelial cells. [PDF]

, 2012
The goal of the present study was to determine whether treatment with cigarette smoke extract (CSE) induces cell loss, cellular senescence, and extracellular matrix (ECM) synthesis in primary human retinal pigment epithelial (RPE) cells. Primary cultured
Johannes Burger, Yu, Alice L., Burger, Johannes, Welge-Lussen, Ulrich, Alice L Yu, Kerstin Birke, Birke, Kerstin, Alice L. Yu, Ulrich Welge-Lussen   +8 more
core   +2 more sources

Development and characterization of a polarized human endometrial cell epithelia in an air–liquid interface state

Stem Cell Research & Therapy, 2018
Human endometrial epithelia undergo injury repair and regeneration with the menstrual cycle; however, mechanisms underpinning the roles of endometrial epithelial cells in endometrial lesions and regeneration remain incompletely understood, mainly owing ...
Dandan Li, Hui Li, Ying Wang, Ahmed Eldomany, Jing Wu, Chao Yuan, Jing Xue, Juan Shi, Yuanyuan Jia, Chunfang Ha, Shuxia Han, Xiaoming Liu, Jiali Yang, Dan Liu   +13 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The apical submembrane cytoskeleton participates in the organization of the apical pole in epithelial cells [PDF]

, 1997
In a previous publication (Rodriguez, M.L., M. Brignoni, and P.J.I. Salas. 1994. J. Cell Sci. 107: 3145-3151), we described the existence of a terminal web-like structure in nonbrush border cells, which comprises a specifically apical cytokeratin ...
Ana L. Viciana, Viciana, A. L., Salas, Pedro J.I, Dora E. Vega-Salas, Hauri, H. P., Hans-Peter Hauri, Marcelo L. Rodriguez, Rodriguez, M. L., Hauri, Hans-Peter, Vega-Salas, D. E., Salas, P. J., Pedro J.I. Salas, Rodriguez, Marcelo L, Vega-Salas, Dora E, Viciana, Ana L   +14 more
core   +1 more source

Th2 Responses Elicited by Nasal Epithelial Cells Exposed to House Dust Mite Extract [PDF]

Clinical and Experimental Otorhinolaryngology, 2009
ObjectivesRespiratory epithelial cells are the first site of interaction of allergens with the immune system. The aim of this study was to examine the effect of epithelial cells, which were stimulated with house dust mite (HDM) extracts, on the immune ...
Seung-Heon Shin, Mi-Kyung Ye
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

TGF-beta 1-induced epithelial-to-mesenchymal transition and therapeutic intervention in diabetic nephropathy [PDF]

, 2010
Background/Aims: Epithelial-to-mesenchymal cell transformation (EMT) is the trans-differentiation of tubular epithelial cells into myofibroblasts, an event underlying progressive chronic kidney disease in diabetes, resulting in fibrosis.
Hills, Claire E., Squires, Paul E.
core   +1 more source

Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Respiratory Research, 2019
Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory ...
Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin, Sheng-xing Zheng   +7 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source