Results 91 to 100 of about 5,847,660 (310)

Apical and basolateral localisation of GLUT2 transporters in human lung epithelial cells [PDF]

, 2008
Glucose concentrations of normal human airway surface liquid are approximately 12.5 times lower than blood glucose concentrations indicating that glucose uptake by epithelial cells may play a role in maintaining lung glucose homeostasis.
Baines, DL, Ratoff, JC, Medina, RA, Rice, S, Suman Rice, Deborah L. Baines, Barbara J. Philips, Wood, DM, David M. Wood, Baker, EH, Kameljit K. Kalsi, Emma H. Baker, Kalsi, KK, Philips, BJ, Jonathan C. Ratoff, Rodolfo A. Medina   +15 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer [PDF]

, 2011
The epithelial to mesenchymal transition (EMT) is a developmental program in which epithelial cells down-regulate their cell-cell junctions, acquire spindle cell morphology and exhibit cellular motility.
Richard R. Meehan, Caldwell Helen, Dubois-Marshall, Sylvie, Sylvie Dubois-Marshall, Helen Caldwell, Sims, Andrew H., Sims Andrew H., Elad Katz, Katz Elad, Elad Katz, Meehan Richard R., Meehan, Richard R, Richard R Meehan, Gautier Philippe, David J. Harrison, Richard R, Harrison David J., Gautier, Philippe, Dubois-Marshall Sylvie, Sims, Andrew H, Philippe Gautier, Harrison, David J, David J Harrison, Katz, Elad, Andrew H. Sims, Meehan, Richard R., Andrew H Sims, Caldwell, Helen, Harrison, David J.   +28 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The Influence of extracellular matrix on lens epithelial cell viability [PDF]

, 2006
Posterior capsular opacification is the main complication of cataract surgery and results from the proliferation, migration and differentiation of lens epithelial cells remaining in the capsular bag. To better understand this pathological cell behaviour,
Frederique, M D Tholozan, Frederique, M.D. Tholozan   +1 more
core  

HMGB-1 - a novel mediator of inflammatory-induced renal epithelial mesenchymal transition [PDF]

, 2010
Background: High mobility group box protein 1 (HMGB-1) is a chromatin binding protein that bends DNA thereby facilitating gene transcription. HMGB-1 has also been observed as an extracellular secreted protein in serum of patients with sepsis and has ...
Ryan, Michael P., Michael P. Ryan, Slattery, Craig, Tara McMorrow, Nolan, Stephen, Ronan Feighery, Craig Slattery, Feighery, Ronan, Stephen Nolan, Julie Lynch, Lynch, Julie, McMorrow, Tara   +11 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]

, 2010
Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde, Wade Bushman, Travis J. Jerde, Zhong Wu, Dan Theodorescu   +4 more
core   +1 more source

Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling

Cell Reports, 2018
Summary: Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest.
Chengkang Zhang, Hyung Joo Lee, Anura Shrivastava, Ruipeng Wang, Travis J. McQuiston, Sharon S. Challberg, Brian A. Pollok, Ting Wang   +7 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source