Results 91 to 100 of about 1,959,501 (356)

Th2 Responses Elicited by Nasal Epithelial Cells Exposed to House Dust Mite Extract [PDF]

Clinical and Experimental Otorhinolaryngology, 2009
ObjectivesRespiratory epithelial cells are the first site of interaction of allergens with the immune system. The aim of this study was to examine the effect of epithelial cells, which were stimulated with house dust mite (HDM) extracts, on the immune ...
Seung-Heon Shin, Mi-Kyung Ye
doaj   +1 more source

Phagocytic properties of lung alveolar wall cells [PDF]

, 1974
For the purpose to define the mechanism of heavy metal intoxication by inhalation, morphologic observations were made on rat lungs after nasal instillation of iron colloid particles of positive and negative electric charges. Histochemical observation was
Tanaka, Akisuke
core   +1 more source

Prostate epithelial stem cells [PDF]

Cell Proliferation, 2005
Abstract.   The prostate gland is the site of the most commonly diagnosed cancer in men in USA and UK, accounting for one in five of new cases of male cancer. Common with many other cancer types, prostate cancer is believed to arise from a stem cell that shares characteristics with the normal stem cell.
S, Rizzo, G, Attard, D L, Hudson
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial–mesenchymal transition

Respiratory Research, 2019
Background Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual anti-inflammatory and inflammatory ...
Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin, Sheng-xing Zheng   +7 more
doaj   +1 more source

Telomerase activity impacts on Epstein-Barr virus infection of AGS cells. [PDF]

PLoS ONE, 2015
The Epstein-Barr virus (EBV) is transmitted from host-to-host via saliva and is associated with epithelial malignancies including nasopharyngeal carcinoma (NPC) and some forms of gastric carcinoma (GC).
Jürgen Rac, Florian Haas, Andrina Schumacher, Jaap M Middeldorp, Henri-Jacques Delecluse, Roberto F Speck, Michele Bernasconi, David Nadal   +7 more
doaj   +1 more source

Pulmonary epithelial stem cells [PDF]

Cell Proliferation, 2004
Abstract.  Classically, the stem/progenitor cells of the pulmonary epithelium are considered to be the basal and mucous cells of the proximal airways, Clara cells in the bronchioles and type II pneumocytes in the alveoli. Recent data suggest that there is a variant of Clara cells, lying in pulmonary neuroendocrine bodies, that meets several stem cell ...
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rhinovirus Infection Drives Complex Host Airway Molecular Responses in Children With Cystic Fibrosis

Frontiers in Immunology, 2020
Early-life viral infections are responsible for pulmonary exacerbations that can contribute to disease progression in young children with cystic fibrosis (CF). The most common respiratory viruses detected in the CF airway are human rhinoviruses (RV), and
Kak-Ming Ling, Kak-Ming Ling, Kak-Ming Ling, Luke W. Garratt, Luke W. Garratt, Luke W. Garratt, Erin E. Gill, Amy H. Y. Lee, Patricia Agudelo-Romero, Patricia Agudelo-Romero, Erika N. Sutanto, Erika N. Sutanto, Thomas Iosifidis, Thomas Iosifidis, Tim Rosenow, Tim Rosenow, Stuart E. Turvey, Timo Lassmann, Robert E. W. Hancock, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick, Stephen M. Stick   +29 more
doaj   +1 more source

Development of an in vitro periodontal biofilm model for assessing antimicrobial and host modulatory effects of bioactive molecules [PDF]

, 2014
Background: Inflammation within the oral cavity occurs due to dysregulation between microbial biofilms and the host response. Understanding how different oral hygiene products influence inflammatory properties is important for the development of new ...
AK Joe, Andrew M Middleton, Anto Jose, BC Dickinson, D Herrera, D Vergara, David F Lappin, DF Lappin, Emma Millhouse, G Hajishengallis, G Ramage, GN Belibasakis, Gordon Ramage, I Palaska, J Pratten, JH Lee, JK Kundu, Jonathan Pratten, JY Jeong, K Boutaga, KJ Herbert, KJ Livak, L Sherry, Leighann Sherry, MA Dickson, MC Sanchez, MF Zarco, MM Chan, MM Tunney, MZ Casati, Nisha Patel, O Fujise, O Turkoglu, R Peyyala, RP Darveau, S Jenkins, S Offenbacher, S Periasamy, Shauna Culshaw, SL Erlandsen, SS Socransky, T Wollert, WA van der Reijden, WG Wade, Z Shan   +44 more
core   +1 more source