Results 101 to 110 of about 5,847,660 (310)

The role of TGF-β and epithelial-to mesenchymal transition in diabetic nephropathy [PDF]

, 2011
Transforming Growth Factor-beta (TGF-β) is a pro-sclerotic cytokine widely associated with the development of fibrosis in diabetic nephropathy. Central to the underlying pathology of tubulointerstitial fibrosis is epithelial-to-mesenchymal transition ...
Hills, Claire E., Paul E. Squires, Claire E. Hills, Squires, Paul E.   +3 more
core   +1 more source

IL-37 attenuated HPV induced inflammation and growth of oral epithelial cells via regulating autophagy

Heliyon
This study investigated the impact of Human Papillomavirus (HPV) on inflammation and growth in oral epithelial cells, with a focus on the role of Interleukin-37 (IL37). Oral epithelial cells, including HOEC and HSC-3 cells, were employed in the research.
Yahong Shi, Wenjing Wang, Yunfang Bai, Xiaoying Liu, Liwei Wu, Ning Liu   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

'Special K' and a loss of cell-to-cell adhesion in proximal tubule-derived epithelial cells : modulation of the adherens junction complex by ketamine [PDF]

, 2013
Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however,
Claire E Hills, Hills Claire E., Jefferson Kieran P., Squires, Paul E., Issac K-K Liu, Tianrong Jin (452021), Jefferson, Kieran P., Liu, Kuo-Kang, Siamantouras Eleftherios, Siamantouras, Eleftherios, Claire E. Hills (452020), Hills, Claire E., Jin, Tianrong, Eleftherios Siamantouras, Paul E. Squires (452025), Jin Tianrong, Issac K-K Liu (452023), Squires Paul E., Tianrong Jin, Paul E Squires, Liu Issac K-K, Kieran P Jefferson, Kieran P. Jefferson (452024), Eleftherios Siamantouras (452022)   +23 more
core   +1 more source

Epstein-Barr virus infection of polarized epithelial cells via the basolateral surface by memory B cell-mediated transfer infection.

PLoS Pathogens, 2011
Epstein Barr virus (EBV) exhibits a distinct tropism for both B cells and epithelial cells. The virus persists as a latent infection of memory B cells in healthy individuals, but a role for infection of normal epithelial is also likely.
Claire Shannon-Lowe, Martin Rowe
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Microrheology of human lung epithelial cells measured by atomic force microscopy [PDF]

, 2003
Lung epithelial cells are subjected to large cyclic forces from breathing. However, their response to dynamic stresses is poorly defined. We measured the complex shear modulus (G*(ω)) of human alveolar (A549) and bronchial (BEAS-2B) epithelial cells over
Farré, Ramon, Buscemi Estefanell, Lara, Trepat Guixer, Xavier, Alcaraz, Jordi, Farré Ventura, Ramon, Buscemi, Lara, Trepat, Xavier, Grabulosa Descals, Mireia, Alcaraz Casademunt, Jordi, Grabulosa, Mireia, Navajas, Daniel, Fabry, Ben, Navajas Navarro, Daniel   +12 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells [PDF]

, 2013
Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexinmediated intercellular communication in proximal tubule-derived epithelial cells.
Mark J. Wall, Hills, Claire E., Michael I. Kerr, Paul E. Squires, Claire E. Hills, Kerr, Michael I., Squires, Paul E., Wall, Mark J.   +7 more
core   +1 more source