Results 41 to 50 of about 5,847,660 (310)

Classical Complement Pathway Inhibition in a Pediatric Patient With Refractory Immune Thrombocytopenia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric refractory immune thrombocytopenia (rITP) is generally characterized by persistent thrombocytopenia and failure to achieve a sustained response to multiple standard therapies. We report a 4‐year‐old female with congenital tufting enteropathy, post‐intestinal transplant patient on immunosuppressants, who developed severe rITP ...
Sarah Hsieh, Susmita Sarangi, Caileigh Pudela, Catherine M. Broome, Tara K. Suntum   +4 more
wiley   +1 more source

Inhibition of the STAT3/Fanconi anemia axis is synthetic lethal with PARP inhibition in breast cancer

Nature Communications
The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity.
Celia D. Rouault, Lucile Bansard, Elena Martínez-Balsalobre, Caroline Bonnet, Julien Wicinski, Shuheng Lin, Ludovic Colombeau, Sylvain Debieu, Guillaume Pinna, Marie Vandamme, Margot Machu, Olivier Rosnet, Véronique Chevrier, Cornel Popovici, Hagay Sobol, Rémy Castellano, Eddy Pasquier, Geraldine Guasch, Raphaël Rodriguez, Julie Pannequin, Jean-Marc Pascussi, Christophe Lachaud, Emmanuelle Charafe-Jauffret, Christophe Ginestier   +23 more
doaj   +1 more source

Bioinformatic Integration of Molecular Networks and Major Pathways Involved in Mice Cochlear and Vestibular Supporting Cells

Frontiers in Molecular Neuroscience, 2018
Background: Cochlear and vestibular epithelial non-hair cells (ENHCs) are the supporting elements of the cellular architecture in the organ of Corti and the vestibular neuroepithelium in the inner ear.
Teresa Requena, Alvaro Gallego-Martinez, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez, Jose A. Lopez-Escamez   +4 more
doaj   +1 more source

Subconfluent ARPE-19 Cells Display Mesenchymal Cell-State Characteristics and Behave like Fibroblasts, Rather Than Epithelial Cells, in Experimental HCMV Infection Studies

Viruses, 2023
Human cytomegalovirus (HCMV) has a broad cellular tropism and epithelial cells are important physiological targets during infection. The retinal pigment epithelial cell line ARPE-19 has been used to model HCMV infection in epithelial cells for decades ...
Preethi Golconda, Mariana Andrade-Medina, Adam Oberstein   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells. [PDF]

, 2011
Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis.
Friedman, N, Oliver Eickelberg, Yu, H, Richards, T., Kaplan, Tommy, Yingze Zhang, Kaplan, T, Pandit, Kusum V., Zhang, Y., Kusum V. Pandit, Richards, Thomas, Benos, Panayiotis V., Zeng, Q, Bais, A.S., Pandit, K.V., Kaminski, N., Handley, D, Bais, Abha S, Richards, T, Panayiotis V. Benos, Handley, Daniel, Richards Thomas, Haiying Yu, Bais, AS, Eickelberg, O, Benos, PV, Nir Friedman, Handley, D., Tommy Kaplan, Friedman, N., Pandit, Kusum V, Zeng, Q., Zhang, Yingze, Abha S Bais, Eickelberg, O., Kusum V Pandit, Bais Abha S., Zeng, Qilu, Yu, Haiying, Panayiotis V Benos, Kaplan, T., Eickelberg Oliver, Kaminski, N, Benos, Panayiotis V, Benos, P.V., Thomas Richards, Eickelberg, Oliver, Naftali Kaminski, Zeng Qilu, Daniel Handley, Pandit, KV, Bais, Abha S., Zhang, Y, Yu Haiying, Kaminski, Naftali, Yu, H., Qilu Zeng, Kaminski Naftali, Benos Panayiotis V., Handley Daniel, Friedman, Nir, Pandit Kusum V., Zhang Yingze, Kaplan Tommy, Friedman Nir, Abha S. Bais   +65 more
core   +1 more source

Oral Mucosal Epithelial Cells

Frontiers in Immunology, 2019
Cellular Phenotype and Apoptosis: The function of epithelial tissues is the protection of the organism from chemical, microbial, and physical challenges which is indispensable for viability.
Sabine Groeger, Joerg Meyle
doaj   +1 more source

Generation of stratified squamous epithelial progenitor cells from mouse induced pluripotent stem cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Application of induced pluripotent stem (iPS) cells in regenerative medicine will bypass ethical issues associated with use of embryonic stem cells.
Satoru Yoshida, Miyuki Yasuda, Hideyuki Miyashita, Yoko Ogawa, Tetsu Yoshida, Yumi Matsuzaki, Kazuo Tsubota, Hideyuki Okano, Shigeto Shimmura   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Human airway xenograft models of epithelial cell regeneration [PDF]

, 2000
Regeneration and restoration of the airway epithelium after mechanical, viral or bacterial injury have a determinant role in the evolution of numerous respiratory diseases such as chronic bronchitis, asthma and cystic fibrosis.
Puchelle Edith, Puchelle, Edith, Peault Bruno, Edith Puchelle, Bruno Peault, Peault, Bruno   +5 more
core   +1 more source