Results 21 to 30 of about 27,376,677 (317)

PEAK1 maintains tight junctions in intestinal epithelial cells and resists colitis by inhibiting autophagy-mediated ZO-1 degradation [PDF]

Nature Communications
Tight junctions are crucial for maintaining intestinal barrier homeostasis, but how organisms modulate these junctions remain unclear. Here, we show a role for PEAK1 at cell-cell contact sites, where it interacts with ZO-1 via a conserved region spanning
Zaikuan Zhang, Yajun Xie, Qiying Yi, Jianing Liu, Lin Yang, Runzhi Wang, Jing Cai, Xinyi Li, Xiaosong Feng, Shixiang Yao, Zheng Pan, Magdalena Paolino, Qin Zhou   +12 more
doaj   +2 more sources

Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]

, 2015
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola, Caparrotta, Laura, Carrara, Maria, Castagliuolo, Ignazio, Catanzaro, Daniela, Dall'Acqua, Stefano, Giron, Maria Cecilia, Montopoli, Monica, Orso, Genny, Ragazzi, Eugenio, Serena, Rancan   +10 more
core   +16 more sources

Dynamic changes of inducible nitric oxide synthase expression in rat’s retina and its role on blood-retinal barrier injury after acute high intraocular pressure [PDF]

International Journal of Ophthalmology, 2022
AIM: To clarify the role of inducible nitric oxide synthase (iNOS) in blood-retinal barrier (BRB) injury after acute high intraocular pressure (IOP) in rats. METHODS: Forty-two Sprague-Dawley (SD) rats were randomized into 7 groups [control (Cont), 3, 6,
Min Li, Ju-Fang Huang, Yi Li, Jing Shen, Lu-Jia Yang, Qian Chen, Quan-Peng Zhang, Xi-Nan Yi   +7 more
doaj   +1 more source

The tight junction protein ZO-1 is dispensable for barrier function but critical for effective mucosal repair.

Gastroenterology, 2021
BACKGROUND S AND AIMS: Increased permeability is implicated in the pathogenesis of intestinal disease. In vitro and in vivo studies have linked downregulation of the scaffolding protein ZO-1, encoded by the TJP1 gene, to increased tight junction ...
W. Kuo, Li Zuo, Matthew A. Odenwald, Shariq Madha, Gurminder Singh, C. Gurniak, C. Abraham, J. Turner   +7 more
semanticscholar   +1 more source

Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood–brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke

Journal of Nanobiotechnology, 2023
Background Blood–brain barrier (BBB) disruption is a major adverse event after ischemic stroke (IS). Caveolin-1 (Cav-1), a scaffolding protein, played multiple roles in BBB permeability after IS, while the pros and cons of Cav-1 on BBB permeability ...
Yiyang Li, Bowen Liu, Tingting Zhao, Xingping Quan, Yan Han, Yaxin Cheng, Yanling Chen, Xu Shen, Ying Zheng, Yonghua Zhao   +9 more
semanticscholar   +1 more source

Filtered Kombucha tea ameliorates the leaky gut syndrome in young and old mice model of colitis [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Zonula occludens proteins (ZO-1 and ZO-2) are important intracellular tight junction (TJ)-associated proteins that link the cell cytoskeleton to the trans-membrane TJ proteins.
Nafiseh Pakravan, Fatemeh Kkermanian, Elaheh Mahmoudi   +2 more
doaj   +1 more source

Cingulin binds to the ZU5 domain of scaffolding protein ZO-1 to promote its extended conformation, stabilization, and tight junction accumulation

Journal of Biological Chemistry, 2022
Zonula occludens-1 (ZO-1), the major scaffolding protein of tight junctions (TJs), recruits the cytoskeleton-associated proteins cingulin (CGN) and paracingulin (CGNL1) to TJs by binding to their N-terminal ZO-1 interaction motif.

semanticscholar   +1 more source

Dexmedetomidine may decrease the bupivacaine toxicity to heart

Open Medicine, 2021
The purpose of our study was to explore the effect of dexmedetomidine on cardiac tolerance to bupivacaine.
Jin Zhousheng, Xia Fangfang, Lin Tingting, Cai Yaoyao, Chen Hongfei, Wang Yuelan   +5 more
doaj   +1 more source

Zonula occludens-1 expression is reduced in nasal epithelial cells of allergic rhinitis patients [PDF]

PeerJ, 2022
Allergic rhinitis (AR) is a common allergic disease characterized by disruption of nasal epithelial barrier. In this study, we investigated the mRNA expression of zonula occludens-1 (ZO-1), ZO-2 and ZO-3 and histone deacetylase 1 (HDAC1) and HDAC2 in AR ...
Che Othman Siti Sarah, Siti Muhamad Nur Husna, Norasnieda Md. Shukri, Kah Keng Wong, Noor Suryani Mohd Ashari   +4 more
doaj   +2 more sources

STAT1/MUC4 activation promotes antimicrobial peptide production to reduce intestinal epithelium barrier injury caused by enteropathogenic Escherichia coli infection

Archives of Medical Science, 2023
Introduction Antimicrobial peptides (AMPs) are endogenous peptides that have been identified to alleviate intestinal epithelial barrier inflammation and dysfunction caused by enteropathogenic Escherichia coli (EPEC) infection; nonetheless, the upstream ...
Liu Pei, Zhigang Zuo, Meixiang Zhang, Likun Zhao, Kaishuang Li   +4 more
doaj   +1 more source