Antioxidants, 2022 Zonula occludens-1 (ZO-1) is a tight junction protein in the cerebrovascular endothelium, responsible for blood–brain barrier function. Hydroxysafflor yellow A (HSYA) is a major ingredient of safflower (Carthamus tinctorius L.) with antioxidative ...
Yi Li +11 more
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ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. [PDF]
PLoS ONE, 2014 ZO-1, ZO-2 and ZO-3 are tight junction-associated scaffold proteins that bind to transmembrane proteins of tight junctions and the underlying cytoskeleton.
Shinsaku Tokuda +2 more
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Tight Junction Protein ZO-1 [PDF]
Definitions, 2020 Tight junction protein ZO-1 (1748 aa, ~195 kDa) is encoded by the human TJP1 gene. This protein plays a role in tight junction formation and signal transduction.
semanticscholar +2 more sources
CHILKBP protects against podocyte injury by preserving ZO-1 expression. [PDF]
Cell Mol Life Sci, 2022 Glomerular diseases afflict millions of people and impose an enormous burden on public healthcare costs worldwide. Identification of potential therapeutic targets for preventing glomerular diseases is of considerable clinical importance. CHILKBP is a focal adhesion protein and modulates a wide array of biological functions.
Guo C +15 more
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ZO-1/Tjp1 and ZO-2/Tjp2 deletion in retinal pigment epithelium causes progressive retinal degeneration [PDF]
iScienceSummary: Tight junction protein-1 and -2 (Tjp1/ZO-1 and Tjp2/ZO-2) function as scaffold proteins within the tight junction complexes of the blood-retinal barrier (BRB). Although the breakdown of the BRB is implicated in retinopathies, the contribution of
Safiah Mohamed Ali +20 more
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Molecular alterations associated with pathophysiology in liver-specific ZO-1 and ZO-2 knockout mice [PDF]
Cell Structure and FunctionThe liver is a complex organ with a highly organized structure in which tight junctions (TJs) play an important role in maintaining their function by regulating barrier properties and cellular polarity.
Masahiko Itoh +3 more
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Roles of claudin-2, ZO-1 and occludin in leaky HK-2 cells. [PDF]
PLoS ONE, 2017 Claudin-2, ZO-1, and occludin are major components of tight junctions (TJs) in the proximal tubule. However, their roles in maintaining paracellular permeability as leaky epithelia have yet to be defined.To investigate the contributory role of TJ ...
Sua Kim, Gheun-Ho Kim
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ZO-1 Regulates Hippo-Independent YAP Activity and Cell Proliferation via a GEF-H1- and TBK1-Regulated Signalling Network [PDF]
CellsTight junctions are a barrier-forming cell–cell adhesion complex and have been proposed to regulate cell proliferation. However, the underlying mechanisms are not well understood.
Alexis J. Haas +4 more
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miRNA-328-3p regulates ZO-1 expression and inhibits PEDV proliferation via the PLC-β1-PKC pathway. [PDF]
PLoS ONEPorcine epidemic diarrhea virus (PEDV) is a significant pathogen affecting swine, causing severe economic losses worldwide. This study explores the regulatory role of miRNA-328-3p to ZO-1 expression and its impact on PEDV proliferation via the PLC-β1-PKC
Han Zhao +13 more
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N-acetylglucosaminyltransferase V drives colorectal cancer metastasis by facilitating ZO-1 ubiquitination and degradation [PDF]
Cancer Cell InternationalIncreasing evidence supports the crucial role of Epithelial-Mesenchymal Transition (EMT) in cancer invasion and metastasis. N-acetylglucosaminyltransferase V (MGAT5), which is associated with multiantenna glycosylation, can contribute to tumorigenesis ...
Yueping Zhan +5 more
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