Results 31 to 40 of about 56,078 (308)

Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage [PDF]

, 2015
Aminosalicylates, corticosteroids and immunosuppressants are currently the therapeutic choices in inflammatory bowel diseases (IBD), however, with limited remission and often serious side effects.
Brun, Paola, Caparrotta, Laura, Carrara, Maria, Castagliuolo, Ignazio, Catanzaro, Daniela, Dall'Acqua, Stefano, Giron, Maria Cecilia, Montopoli, Monica, Orso, Genny, Ragazzi, Eugenio, Serena, Rancan   +10 more
core   +6 more sources

P16INK4a Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency

Frontiers in Cell and Developmental Biology, 2021
This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier destruction and microbiota dysfunction, which members of the microbial community alter barrier function with age, and whether p16INK4a deletion could reverse ...
Jiawen Zhou, Chenxing Hou, Haiyun Chen, Ziyue Qin, Zi’an Miao, Jingyu Zhao, Qiuyi Wang, Min Cui, Chunfeng Xie, Rong Wang, Qing Li, Guoping Zuo, Dengshun Miao, Dengshun Miao, Jianliang Jin   +14 more
doaj   +1 more source

Artificial rearing influences the morphology, permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets [PDF]

, 2017
Background: In this study the physiological implications of artificial rearing were investigated. Low (LBW) and normal birth weight (NBW) piglets were compared as they might react differently to stressors caused by artificial rearing.
Casteleyn, Christophe, De Smet, Stefaan, Degroote, Jeroen, Fransen, Erik, Michiels, Joris, Prims, Sara, Van Cruchten, Steven, Van Ginneken, Chris, Vergauwen, Hans, Wang, Wei   +9 more
core   +1 more source

Occludin: a gatekeeper of brain Infection by HIV-1

Fluids and Barriers of the CNS, 2023
AbstractCompromised structure and function of the blood-brain barrier (BBB) is one of the pathological hallmarks of brain infection by HIV-1. BBB damage during HIV-1 infection has been associated with modified expression of tight junction (TJ) proteins, including occludin. Recent evidence indicated occludin as a redox-sensitive, multifunctional protein
Silvia Torices, Leah Daire, Sierra Simon, Oandy Naranjo, Luisa Mendoza, Timea Teglas, Nikolai Fattakhov, Daniel Adesse, Michal Toborek   +8 more
openaire   +3 more sources

Pengaruh Pemberian Probiotik Terhadap Integritas Usus pada Obesitas: Uji Coba pada Tikus Sprague Dawley

Sari Pediatri, 2022
Latar belakang. Obesitas berhubungan dengan perubahan komposisi mikrobiota usus yang dapat mengganggu integritas usus. Protein pengikat tight junction, occludin, ekspresinya berkurang saat integritas usus terganggu. Probiotik dilaporkan dapat memperbaiki
Mira Mariana Ulfah, Ninung Rose Diana Kusumawati   +1 more
doaj   +1 more source

Occludin is overexpressed in Alzheimer's disease and vascular dementia [PDF]

Journal of Cellular and Molecular Medicine, 2007
AbstractThe tight junctions (TJs) are key players in the control of blood‐brain barrier (BBB) properties, the most complex TJs in the vascular system being found in the endothelial cells of brain capillaries. One of the main TJs proteins is occludin, which anchors plasma membranes of neighbour cells and is present in large amounts in the brain ...
Romanitan, Mihaela Oana, Popescu, Bogdan O, Winblad, Bengt, Bajenaru, Ovidiu Alexandru, Bogdanovic, Nenad   +4 more
openaire   +2 more sources

Evaluation of LncRNA uc.173 and Occludin in Iranian Patients with Inflammatory Bowel Disease Compared with Healthy Individuals [PDF]

Journal of Advanced Biomedical Sciences, 2022
Background & Objective: Inflammatory bowel disease (IBD) is characterized by the chronic gastrointestinal inflammation. The two common forms of IBD are ulcerative colitis (UC) and Crohn’s disease (CD) that are distinguished by their location and depth of
Vahid Chaleshi, Saeideh Oloumi Kalantar, Iman Salahshourifar, Shabnam Shahrokh, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali   +5 more
doaj  

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. [PDF]

, 2018
BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain ...
Cespedes, Juan Carlos, Ford, Byron, Liu, Mingli, Solomon, Wesley, Stiles, Jonathan K, Wilson, Nana O   +5 more
core   +1 more source

Occludin Localizes to Centrosomes and Modifies Mitotic Entry [PDF]

Journal of Biological Chemistry, 2011
Proper control of cell cycle progression and barrier function are essential processes to the maintenance of epithelial cell homeostasis. The contribution of tight junction proteins to barrier function is well established, whereas their contribution to cell cycle control is only beginning to be understood.
E Aaron, Runkle, Jeffrey M, Sundstrom, Kristin B, Runkle, Xuwen, Liu, David A, Antonetti   +4 more
openaire   +2 more sources

Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis [PDF]

, 2017
Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized ...
Brilha, Sara, Couraud, Pierre-Olivier, Friedland, Jon S, Ong, Catherine W M, Romero, Nacho, Weksler, Babette   +5 more
core   +3 more sources