Results 31 to 40 of about 46,424 (193)

P16INK4a Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency

open access: yesFrontiers in Cell and Developmental Biology, 2021
This study aimed to determine whether Bmi-1 deficiency leads to intestinal epithelial barrier destruction and microbiota dysfunction, which members of the microbial community alter barrier function with age, and whether p16INK4a deletion could reverse ...
Jiawen Zhou   +14 more
doaj   +1 more source

Hemodynamic regulation of occludin and ZO-1: effect on barrier function [PDF]

open access: yes, 2006
The vascular endothelium constitutes a highly effective fluid and solute barrier through the regulated apposition of tight junction protein complexes between adjacent endothelial cells.
Collins, Nora
core   +2 more sources

Loss of Occludin Affects Tricellular Localization of Tricellulin [PDF]

open access: yesMolecular Biology of the Cell, 2008
The tricellular tight junction (tTJ) forms at the convergence of bicellular tight junctions (bTJs) where three epithelial cells meet in polarized epithelia, and it is required for the maintenance of the transepithelial barrier. Tricellulin is a four transmembrane domain protein recently identified as the first marker of tTJ, but little is known about ...
Junichi, Ikenouchi   +4 more
openaire   +2 more sources

Pengaruh Pemberian Probiotik Terhadap Integritas Usus pada Obesitas: Uji Coba pada Tikus Sprague Dawley

open access: yesSari Pediatri, 2022
Latar belakang. Obesitas berhubungan dengan perubahan komposisi mikrobiota usus yang dapat mengganggu integritas usus. Protein pengikat tight junction, occludin, ekspresinya berkurang saat integritas usus terganggu. Probiotik dilaporkan dapat memperbaiki
Mira Mariana Ulfah   +1 more
doaj   +1 more source

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. [PDF]

open access: yesThe Journal of cell biology, 1994
Occludin is an integral membrane protein localizing at tight junctions (TJ) with four transmembrane domains and a long COOH-terminal cytoplasmic domain (domain E) consisting of 255 amino acids. Immunofluorescence and laser scan microscopy revealed that chick full-length occludin introduced into human and bovine epithelial cells was correctly delivered ...
M, Furuse   +6 more
openaire   +2 more sources

Claudin and occludin expression and function in the seminiferous epithelium [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2010
Integral membrane proteins that contribute to function of the blood–testes barrier (BTB) in mice include claudins 3, 5 and 11 and occludin. Although claudin 11 is expressed throughout all stages of the seminiferous epithelial cycle, claudins 3 and 5 have specific expression at stage VIII.
Carla M K, Morrow   +3 more
openaire   +2 more sources

Cinnamon pretreatment modulates gene expression of tight junction proteins in a rat model of stroke [PDF]

open access: yesAvicenna Journal of Phytomedicine
Objective: Brain ischemia generally results in irreversible brain damage or death. One of the most important features of an ischemic stroke is disruption of the Blood-brain barrier (BBB).
Solmaz Najjary   +4 more
doaj   +1 more source

Brain blood vessel autoantibodies in patients with NMDA and GABAA receptor encephalitis: identification of unconventional Myosin-X as target antigen

open access: yesFrontiers in Cellular Neuroscience, 2023
Introduction: The antibody repertoire from CSF-derived antibody-secreting cells and memory B-cells in patients with encephalitis contains a considerable number of antibodies that do not target the disease-defining autoantigen such as the GABA or NMDA ...
Lucie Y. Li   +23 more
doaj   +1 more source

Occludin: One Protein, Many Forms [PDF]

open access: yesMolecular and Cellular Biology, 2012
Intercellular tight junctions (TJs) exhibit a complex molecular architecture involving the regulated cointeraction of cytoplasmic adaptor proteins (e.g., zonula occludens) and integral membrane linker proteins (e.g., occludin and claudins). They provide structural integrity to epithelial and endothelial tissues and create highly polarized barriers ...
openaire   +2 more sources

Serum Occludin Level Combined With NIHSS Score Predicts Hemorrhage Transformation in Ischemic Stroke Patients With Reperfusion

open access: yesFrontiers in Cellular Neuroscience, 2021
Hemorrhagic transformation (HT) is a severe complication following acute ischemic stroke, particularly with reperfusion interventions, leading to poor prognosis.
Shuhua Yuan   +7 more
doaj   +1 more source

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