Results 51 to 60 of about 80,593 (229)

Claudins in lung diseases [PDF]

open access: yesRespiratory Research, 2011
Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
openaire   +3 more sources

A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins

open access: yesToxins, 2023
Background: Clostridioides difficile toxins TcdA and TcdB are responsible for diarrhea and colitis. Lack of functional studies in organoid models of the gut prompted us to elucidate the toxin’s effects on epithelial barrier function and the molecular ...
Martina Schneemann   +9 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Selection of dune shapes and velocities. Part 1: Dynamics of sand, wind and barchans

open access: yes, 2002
Almost fifty years of investigations of barchan dunes morphology and dynamics is reviewed, with emphasis on the physical understanding of these objects. The characteristics measured on the field (shape, size, velocity) and the physical problems they rise
Andreotti, Bruno   +2 more
core   +3 more sources

Could an endoneurial endothelial crosstalk between Wnt/β-catenin and Sonic Hedgehog pathways underlie the early disruption of the infra-orbital blood-nerve barrier following chronic constriction injury? [PDF]

open access: yes, 2017
BackgroundBlood–nerve barrier disruption is pivotal in the development of neuroinflammation, peripheral sensitization, and neuropathic pain after peripheral nerve injury.
Boucher, Yves   +7 more
core   +4 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

open access: yesAdvanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi   +2 more
wiley   +1 more source

Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons

open access: yesFrontiers in Molecular Neuroscience, 2018
In the retina of teleost fish, cell addition continues throughout life involving proliferation and axonal growth. To study how this is achieved in a fully functioning retina, we investigated the nerve fiber layer (NFL) of the cichlid fish Astatotilapia ...
Lidia Garcia-Pradas   +4 more
doaj   +1 more source

Giant ripples on comet 67P/Churyumov-Gerasimenko sculpted by sunset thermal wind

open access: yes, 2017
Explaining the unexpected presence of dune-like patterns at the surface of the comet 67P/Churyumov-Gerasimenko requires conceptual and quantitative advances in the understanding of surface and outgassing processes. We show here that vapor flow emitted by
Andreotti, B., Claudin, P., Jia, P.
core   +3 more sources

Versatility of NaCl transport mechanisms in the cortical collecting duct [PDF]

open access: yes, 2017
Versatility of NaCl transport mechanisms in the cortical collecting duct. Am J Physiol Renal Physiol 313: F1254 –F1263, 2017. First published September 6, 2017; doi:10.1152/ajprenal.00369.2017.—The cortical collecting duct (CCD) forms part of the ...
Crambert, Gilles, Edwards, Aurelie
core   +1 more source

Claudins and gastric carcinogenesis

open access: yesExperimental Biology and Medicine, 2013
Gastric carcinoma arises from aberrant growth of normal gastric mucosa. There is increasing evidence that claudins (CLDNs) may play a critical role in the significant steps of gastric tumorigenesis, from metaplasia to metastasis. The CLDN family which consists of at least 27 member proteins is known to mediate selective permeability in cellular tight ...
Omid, Iravani   +4 more
openaire   +2 more sources

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