Results 51 to 60 of about 79,602 (359)
Frontiers in Pharmacology, 2016 Background: Alkali burn is a frequently occurring ocular injury that resembles ocular inflammation caused by eye allergies, infection, and refractive surgeries.Methods: We investigated the synergistic regenerative potential of dominant negative survivin ...
Kislay Roy +3 more
doaj +1 more source
Claudin-2 and occludin protein expressions.
, 2018 Western blot was used to measure claudin-2 (Fig 6A) and occludin (Fig 6B) protein expressions in intestine. The levels of claudin-2 and occludin in FF and BO groups were significantly decreased compared to the FO group. Claudin-2 and occludin levels were
David Clark (738) +9 more
core +1 more source
Heterogeneity of claudin 18.2 expression in metastatic gastric cancer
Scientific ReportsClaudin 18.2 has emerged as a viable therapeutic target in gastric cancer (GC), but little is known about the heterogeneity of its expression in GC. This study investigated the heterogeneity of claudin 18.2 expression in 166 patients with metastatic GC ...
Eugene Choi +4 more
semanticscholar +1 more source
Barriers built on claudins [PDF]
Journal of Cell Science, 2004 The fundamental functions of epithelia and endothelia in multicellular organisms are to separate compositionally distinct compartments and regulate the exchange of small solutes and other substances between them. Tight junctions (TJs) between adjacent cells constitute the barrier to the passage of ions and molecules through the paracellular pathway and
Kursad, Turksen, Tammy-Claire, Troy
openaire +2 more sources
Frontiers in Neuroscience, 2020 Neural tube defects (NTDs) are severe malformations of the central nervous system that affect 1–2 individuals per 2,000 births. Their etiology is complex and involves both genetic and environmental factors.
Amanda I. Baumholtz +6 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Sepsis is responsible for nearly 20% of deaths worldwide. Current therapy for sepsis is restricted to antibiotics directed toward the initiating pathogen, combined with non-specific supportive care.
Takehiko Oami +12 more
semanticscholar +1 more source
Claudins in lung diseases [PDF]
Respiratory Research, 2011 Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
openaire +3 more sources
MoleculesBackground: Considering the increasing worldwide prevalence of inflammatory bowel disease (IBD), the early diagnosis of this disease is extremely important.
Aleksandra Górecka +5 more
semanticscholar +1 more source
Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
Clinical and Translational Oncology, 2020 Introduction The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and ...
Alexander Arnold +7 more
semanticscholar +1 more source
Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Claudin (CLDN) proteins, a tetra-transmembrane family containing over 20 members, have been identified as key structural and functional components of intercellular seals, tight junctions (TJs). CLDNs are involved in the barrier and fence functions of TJs. Loosening the TJ barrier is one strategy for increasing drug absorption and delivery to the brain.
Yosuke, Hashimoto +7 more
openaire +2 more sources