Results 51 to 60 of about 56,637 (316)

Claudins in lung diseases [PDF]

Respiratory Research, 2011
Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions.
openaire   +3 more sources

Claudin-16 and claudin-19 function in the thick ascending limb [PDF]

Current Opinion in Nephrology and Hypertension, 2010
Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport function for magnesium reabsorption in the TAL.Mutations in the genes encoding the tight junction proteins
Jianghui, Hou, Daniel A, Goodenough
openaire   +2 more sources

Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons

Frontiers in Molecular Neuroscience, 2018
In the retina of teleost fish, cell addition continues throughout life involving proliferation and axonal growth. To study how this is achieved in a fully functioning retina, we investigated the nerve fiber layer (NFL) of the cichlid fish Astatotilapia ...
Lidia Garcia-Pradas, Corinna Gleiser, Andrea Wizenmann, Hartwig Wolburg, Andreas F. Mack   +4 more
doaj   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

eLife, 2020
Diabetes mellitus is a known susceptibility factor for severe influenza virus infections. However, the mechanisms that underlie this susceptibility remain incompletely understood.
Katina D Hulme, Limin Yan, Rebecca J Marshall, Conor J Bloxham, Kyle R Upton, Sumaira Z Hasnain, Helle Bielefeldt-Ohmann, Zhixuan Loh, Katharina Ronacher, Keng Yih Chew, Linda A Gallo, Kirsty R Short   +11 more
doaj   +1 more source

The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]

, 2009
The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Nougayrède, Jean-Philippe, Oswald, Isabelle P, Moreno, Carolina, Marin, Daniela E., Loureiro-Bracarense, Ana-Paula, Ferrier, Laurent, Oswald, Isabelle P., Pinton, Philippe, Del Rio, Juan-Carlos, Kolf-Clauw, Martine, Bracarense, Ana-Paula   +10 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Early Radiation-Induced Changes in Lung Tissue and Intercellular Junctions: Implications for Tissue Repair and Fibrosis

Pathophysiology
Early changes in lung tissue following ionizing radiation (IR) initiate processes that may lead to either regeneration or fibrosis. Intercellular junction proteins play a crucial role in the organization and function of epithelial tissues, both under ...
Ekaterina S. Karetnikova, Alexandra A. Livanova, Arina A. Fedorova, Alexander G. Markov   +3 more
doaj   +1 more source

Identification of a claudin-low subtype in clear cell renal cell carcinoma with implications for the evaluation of clinical outcomes and treatment efficacy

Frontiers in Immunology, 2022
BackgroundIn bladder and breast cancer, the claudin-low subtype is widely identified, revealing a distinct tumor microenvironment (TME) and immunological feature.
Cuijian Zhang, Cuijian Zhang, Cuijian Zhang, Yifan Li, Yifan Li, Yifan Li, Jinqin Qian, Jinqin Qian, Jinqin Qian, Zhenpeng Zhu, Zhenpeng Zhu, Zhenpeng Zhu, Cong Huang, Cong Huang, Cong Huang, Zhisong He, Zhisong He, Zhisong He, Liqun Zhou, Liqun Zhou, Liqun Zhou, Yanqing Gong, Yanqing Gong, Yanqing Gong   +23 more
doaj   +1 more source

Claudins in the Renal Collecting Duct [PDF]

International Journal of Molecular Sciences, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis. The collecting duct epithelium is comprised of a tight epithelial barrier resulting in a strict separation of intraluminal urine and the
Janna Leiz, Kai M. Schmidt-Ott
openaire   +3 more sources