Results 31 to 40 of about 79,602 (359)
The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
Cells, 2023 Cell adhesion molecules, including integrins, cadherins, and claudins (CLDNs), are known to activate Src-family kinases (SFKs) that organize a variety of physiological and pathological processes; however, the underlying molecular basis remains unclear ...
Naoki Ichikawa-Tomikawa +3 more
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Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently
Scientific Reports, 2020 The transmembrane protein claudin-1 is a major component of epidermal tight junctions (TJs), which create a dynamic paracellular barrier in the epidermis. Claudin-1 downregulation has been linked to atopic dermatitis (AD) pathogenesis but variable levels
Sophia Bergmann +15 more
semanticscholar +1 more source
Communications Biology, 2021 Claudin-2 promotes breast cancer liver metastasis by enabling seeding and early cancer cell survival. We now demonstrate that Claudin-2 is functionally required for colorectal cancer liver metastasis and that Claudin-2 expression in primary colorectal ...
S. Tabariès +21 more
semanticscholar +1 more source
Journal of the American Society of Nephrology, 2015 Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. In the proximal tubule, claudins have a role in the bulk reabsorption of salt and water.
openaire +2 more sources
Intestinal fluid absorption in anadromous salmonids: importance of tight junctions and aquaporins
Frontiers in Physiology, 2012 The anadromous salmonid life cycle includes both fresh water (FW) and seawater (SW) stages. The parr-smolt transformation (smoltification) pre–adapt the fish to SW while still in FW.
Kristina eSundell, Henrik eSundh
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Cells, 2020 The homologs EpCAM and TROP2, which both interact with claudin-1 and claudin-7, are frequently coexpressed in epithelia including skin. Intestine uniquely expresses high levels of EpCAM but not TROP2.
Chuan-Jin Wu +4 more
doaj +1 more source
JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function
Circulation Research, 2020 Supplemental Digital Content is available in the text. Rationale: Intercellular tight junctions are crucial for correct regulation of the endothelial barrier. Their composition and integrity are affected in pathological contexts, such as inflammation and
Nikolaos Kakogiannos +19 more
semanticscholar +1 more source
Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells
Nature Communications, 2021 Claudin-low breast cancer represents an aggressive molecular subtype that is comprised of mostly triple-negative mammary tumor cells that possess stem cell-like and mesenchymal features.
P. D. Rädler +9 more
semanticscholar +1 more source
American Journal of Physiology-Renal Physiology, 2008 Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule, and mutations in two claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review,
Susanne, Angelow +2 more
openaire +3 more sources
Journal of Clinical Investigation, 2020 The tight junction protein claudin-2 is upregulated in disease. Although many studies have linked intestinal barrier loss to local and systemic disease, these have relied on macromolecular probes.
Preeti Raju +9 more
semanticscholar +1 more source