Results 31 to 40 of about 56,637 (316)

Claudins and the Kidney [PDF]

Journal of the American Society of Nephrology, 2015
Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. In the proximal tubule, claudins have a role in the bulk reabsorption of salt and water.
openaire   +2 more sources

Myrrh protects against IL-13-induced epithelial barrier breakdown in HT-29/B6 cells

Frontiers in Pharmacology, 2023
The oleoresin myrrh has been used for centuries as an anti-inflammatory remedy for a variety of diseases and is said to have a protective effect on the intestinal epithelium.
Helena Hader, Nina A. Hering, Jörg-Dieter Schulzke, Roland Bücker, Rita Rosenthal   +4 more
doaj   +1 more source

Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the BloodBrain Barrier

, 2021
Aging-induced alterations to the blood–brain barrier (BBB) are increasingly being seen as a primary event in chronic progressive neurological disorders that lead to cognitive decline.
Alex Vecchio, Saiprasad Gowrikumar (5581430), Forrest M. Kievit (1341276), Punita Dhawan (158034), Forrest M. Kievit, Connor C. Gee, Punita Dhawan, Sourav Roy, Evan T. Curtis (11663911), Hunter A. Miller, Saiprasad Gowrikumar, Badrul Alam Bony (11663902), Aria W. Tarudji, Connor C. Gee (11663914), Sourav Roy (389598), Hunter A. Miller (11663908), Alex Vecchio (11663917), Badrul Alam Bony, Evan T. Curtis, Aria W. Tarudji (11663905)   +19 more
core   +1 more source

The Expression and Localization of ZO-1, Claudin 1, and Claudin 4 in the Pig Epididymis

Journal of Animal Reproduction and Biotechnology, 2019
Tight junctions are constituents of the blood–epididymis barrier that play roles in regulating the unidirectional transcellular transport of ions, water, and solutes to maintain optimal conditions for sperm maturation and storage. Claudin 1 (Cldn1) and 4
Yun-Jae Park, Bongki Kim
doaj   +1 more source

Identification of key claudin genes associated with survival prognosis and diagnosis in colon cancer through integrated bioinformatic analysis

Frontiers in Genetics, 2023
The claudin multigene family is associated with various aberrant physiological and cellular signaling pathways. However, the association of claudins with survival prognosis, signaling pathways, and diagnostic efficacy in colon cancer remains poorly ...
Rana A. Alghamdi, Rana A. Alghamdi, Maryam H. Al-Zahrani   +2 more
doaj   +1 more source

The role and mechanism of claudins in cancer

Frontiers in Oncology, 2022
Claudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling ...
De-Wen Wang, De-Wen Wang, Wei-Han Zhang, Wei-Han Zhang, Galiullin Danil, Galiullin Danil, Galiullin Danil, Kun Yang, Kun Yang, Jian-Kun Hu, Jian-Kun Hu   +10 more
doaj   +1 more source

Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review

Pharmaceutics, 2020
The blood-brain barrier (BBB), which is composed of endothelial cells, pericytes, astrocytes, and neurons, separates the brain extracellular fluid from the circulating blood, and maintains the homeostasis of the central nervous system (CNS).
Keisuke Tachibana, Yumi Iwashita, Erika Wakayama, Itsuki Nishino, Taiki Nishikaji, Masuo Kondoh   +5 more
doaj   +1 more source

Barriers built on claudins [PDF]

Journal of Cell Science, 2004
The fundamental functions of epithelia and endothelia in multicellular organisms are to separate compositionally distinct compartments and regulate the exchange of small solutes and other substances between them. Tight junctions (TJs) between adjacent cells constitute the barrier to the passage of ions and molecules through the paracellular pathway and
Kursad, Turksen, Tammy-Claire, Troy
openaire   +2 more sources

cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids

Pharmaceutics, 2023
Claudins regulate paracellular permeability, contribute to epithelial polarization and are dysregulated during inflammation and carcinogenesis. Variants of the claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) are highly sensitive ...
Ayk Waldow, Laura-Sophie Beier, Janine Arndt, Simon Schallenberg, Claudia Vollbrecht, Philip Bischoff, Martí Farrera-Sal, Florian N. Loch, Christian Bojarski, Michael Schumann, Lars Winkler, Carsten Kamphues, Lukas Ehlen, Jörg Piontek   +13 more
doaj   +1 more source

Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn

Frontiers in Pharmacology, 2016
Background: Alkali burn is a frequently occurring ocular injury that resembles ocular inflammation caused by eye allergies, infection, and refractive surgeries.Methods: We investigated the synergistic regenerative potential of dominant negative survivin ...
Kislay Roy, Bhasker Sriramoju, Rupinder K. Kanwar, Jagat R. Kanwar   +3 more
doaj   +1 more source