Results 1 to 10 of about 2,075,044 (304)

CU104, a novel barrier function enhancer, improves colitis via modulation of barrier function and immune cell recruitment. [PDF]

Front Immunol
BackgroundInflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a chronic and relapsing condition with complex pathogenesis and limited therapeutic options.
Park IS, Kim JH, Kim D, Kim YW, Shin Y, Kim KB, Zhang H, Kim TI, Kim SW, Kwon YG, Cheon JH.   +10 more
europepmc   +2 more sources

Enhancing Extracellular Adenosine Levels Restores Barrier Function in Acute Lung Injury Through Expression of Focal Adhesion Proteins

Frontiers in Molecular Biosciences, 2021
Background: Acute respiratory distress syndrome (ARDS) is a clinical presentation of acute lung injury (ALI) with often fatal lung complication. Adenosine, a nucleoside generated following cellular stress provides protective effects in acute injury.
Wei Wang, Ning-yuan Chen, Dewei Ren, Jonathan Davies, Kemly Philip, Holger K. Eltzschig, Michael R. Blackburn, Michael R. Blackburn, Bindu Akkanti, Harry Karmouty-Quintana, Harry Karmouty-Quintana, Harry Karmouty-Quintana, Tingting Weng, Tingting Weng   +13 more
doaj   +1 more source

Sucrose-induced hyperglycemia dysregulates intestinal zinc metabolism and integrity: risk factors for chronic diseases

Frontiers in Nutrition, 2023
ObjectiveZinc is an essential micronutrient that is critical for many physiological processes, including glucose metabolism, regulation of inflammation, and intestinal barrier function.
Samuel Blake Mitchell, Yu-Han Hung, Yu-Han Hung, Trista Lee Thorn, Jiaqi Zou, Filiz Baser, Sukru Gulec, Celeste Cheung, Tolunay Beker Aydemir   +8 more
doaj   +1 more source

Plasmodium falciparum and TNF-α Differentially Regulate Inflammatory and Barrier Integrity Pathways in Human Brain Endothelial Cells

mBio, 2022
Cerebral malaria is a severe complication of Plasmodium falciparum infection characterized by the loss of blood-brain barrier (BBB) integrity, which is associated with brain swelling and mortality in patients. P.
Marisol Zuniga, Claudia Gomes, Ze Chen, Criseyda Martinez, Joseph Cooper Devlin, P’ng Loke, Ana Rodriguez   +6 more
doaj   +1 more source

Fumonisin B₁ Inhibits Cell Proliferation and Decreases Barrier Function of Swine Umbilical Vein Endothelial Cells

Toxins, 2021
The fumonisins are a group of common mycotoxins found around the world that mainly contaminate maize. As environmental toxins, they pose a threat to human and animal health. Fumonisin B1 (FB1) is the most widely distributed and the most toxic.
Qing Li, Qiaoling Yuan, Tianjie Wang, Yang Zhan, Lingchen Yang, Ying Fan, Hongyu Lei, Jianming Su   +7 more
doaj   +1 more source

A Protective Role of FAM13A in Human Airway Epithelial Cells Upon Exposure to Cigarette Smoke Extract

Frontiers in Physiology, 2021
BackgroundChronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by chronic inflammation upon inhalation of noxious particles, e.g., cigarette smoke.
Qing Chen, Qing Chen, Maaike de Vries, Maaike de Vries, Kingsley Okechukwu Nwozor, Kingsley Okechukwu Nwozor, Jacobien A. Noordhoek, Jacobien A. Noordhoek, Jacobien A. Noordhoek, Corry-Anke Brandsma, Corry-Anke Brandsma, H. Marike Boezen, H. Marike Boezen, Irene H. Heijink, Irene H. Heijink, Irene H. Heijink   +15 more
doaj   +1 more source

Effects of Bacillus licheniformis and Bacillus subtilis on Gut Barrier Function, Proinflammatory Response, ROS Production and Pathogen Inhibition Properties in IPEC-J2—Escherichia coli/Salmonella Typhimurium Co-Culture

Microorganisms, 2022
The emergence of antimicrobial resistance raises serious concerns worldwide. Probiotics offer a promising alternative to enhance growth promotion in farm animals; however, their mode of action still needs to be elucidated.
Nikolett Palkovicsné Pézsa, Dóra Kovács, Bence Rácz, Orsolya Farkas   +3 more
doaj   +1 more source

Chloride channels regulate differentiation and barrier functions of the mammalian airway. [PDF]

, 2020
The conducting airway forms a protective mucosal barrier and is the primary target of airway disorders. The molecular events required for the formation and function of the airway mucosal barrier, as well as the mechanisms by which barrier dysfunction ...
Caplan, Michael J, Chen, Yuzhang, Darmanis, Spyros, He, Mu, Jan, Lily Yeh, Jan, Yuh Nung, Le, Daniel D, Li, Ke-Xin, Neff, Norma, Padovano, Valeria, Sinclair, Adriane W, Sit, Rene, Tan, Michelle, Wu, Bing, Ye, Wenlei   +14 more
core   +2 more sources

Desmosomes as Signaling Hubs in the Regulation of Cell Behavior

Frontiers in Cell and Developmental Biology, 2021
Desmosomes are intercellular junctions, which preserve tissue integrity during homeostatic and stress conditions. These functions rely on their unique structural properties, which enable them to respond to context-dependent signals and transmit them to ...
Lisa Müller, Mechthild Hatzfeld, René Keil   +2 more
doaj   +1 more source

Controlling the Schottky barrier at MoS2|metal contacts by inserting a BN monolayer [PDF]

, 2015
Making a metal contact to the two-dimensional semiconductor MoS2 without creating a Schottky barrier is a challenge. Using density functional calculations we show that, although the Schottky barrier for electrons obeys the Schottky-Mott rule for high ...
Brocks, Geert, Farmanbar, Mojtaba
core   +13 more sources