Results 91 to 100 of about 79,602 (359)

Claudin-1 protein expression levels determined by western blot.

, 2016
The relative folds changes of Claudin-1 in the SO, CPB, MHCA and DHCA groups were 1.000 ± 0.130, 0.992 ± 0.069, 0.956 ± 0.062 and 0.784 ± 0.054, respectively. Mean ± SD; n = 5. **P < 0.05 DHCA vs. CPB; ^ P < 0.05 DHCA vs. MHCA.
Mengya Liang (3186129), Zhixian Tang (3186135), Xiao Yang (19898), Jian Rong (598108), Weibin Lin (3186132), Guangxian Chen (3186126), Zhongkai Wu (2287063), Kangni Feng (3186123)   +7 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Which Russia, twenty years later?

Revista CIDOB d'Afers Internacionals, 2011
Russia is proud of its position among the emerging powers, of the strength provided by its ample energetic resources and its nuclear potential with which it can influence the world and always be taken into account. Nevertheless, the perception within the
Carmen Claudín
doaj  

Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas

Cancer Medicine, 2019
Claudin (CLDN) family comprises of protein that form a tight junction, and is involved in regulating polarity and differentiation of cells. Here, we aimed to investigate the effects of inhibiting CLDN4 in pancreatic ductal carcinomas (PDC).
Takamitsu Sasaki, Rina Fujiwara‐Tani, Shingo Kishi, Shiori Mori, Yi Luo, Hitoshi Ohmori, Isao Kawahara, Kei Goto, Yukiko Nishiguchi, Takuya Mori, Masayuki Sho, Masuo Kondo, Hiroki Kuniyasu   +12 more
doaj   +1 more source

Claudins

European Journal of Histochemistry, 2012
I am pretty sure that I don’t have to spend a single word to talk about the role played by tight junctions in biological processes and in keeping alive the cellular bases of life ! But I am sure as well that the readers should appreciate at least some sentences about this relatively new entry (Claudins have been discovered in 1998) in the world of the ...
openaire   +3 more sources

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Human Claudin-Derived Peptides Block the Membrane Fusion Process of Zika Virus and Are Broad Flavivirus Inhibitors

Microbiology Spectrum, 2022
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged in the Pacific islands in 2007 and spread to the Americas in 2015. The infection remains asymptomatic in most cases but can be associated with severe neurological disorders.
Jim Zoladek, Julien Burlaud-Gaillard, Maxime Chazal, Sophie Desgraupes, Patricia Jeannin, Antoine Gessain, Nathalie Pardigon, Mathieu Hubert, Philippe Roingeard, Nolwenn Jouvenet, Philippe V. Afonso   +10 more
doaj   +1 more source

Structure and function of claudins

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2008
Claudins are tetraspan transmembrane proteins of tight junctions. They determine the barrier properties of this type of cell-cell contact existing between the plasma membranes of two neighbouring cells, such as occurring in endothelia or epithelia. Claudins can completely tighten the paracellular cleft for solutes, and they can form paracellular ion ...
Krause, Gerd, Winkler, Lars, Mueller, Sebastian L., Haseloff, Reiner F., Piontek, Jörg, Blasig, Ingolf E.   +5 more
openaire   +2 more sources

Claudins in the Renal Collecting Duct [PDF]

International Journal of Molecular Sciences, 2019
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis. The collecting duct epithelium is comprised of a tight epithelial barrier resulting in a strict separation of intraluminal urine and the
Janna Leiz, Kai M. Schmidt-Ott
openaire   +3 more sources