Results 101 to 110 of about 80,593 (229)

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors

Molecular Therapy: Oncology
There are very few syngeneic mouse cell line models available for gastric cancer owing to the rarity of stomach epithelium-specific promoter. Mouse cell line models are useful to study an immunologically intact tumor microenvironment, especially in the ...
Min-Jung Seo, Jin Hue Jeong, Han Na Park, In-Pyo Baek, Jun Won Park, Seo Young Kim, Yu Ri Choi, Seulki Choi, Seung Min Ham, Dongmin Park, Hye-Ran Kim, Ho Kyung Seo, Hark Kyun Kim   +12 more
doaj   +1 more source

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

The changes in biomarkers for necrotising enterocolitis in premature calves with respiratory distress syndrome

Veterinární Medicína, 2019
The aim of this study was to determine the changes of the biomarkers used for the diagnosis of necrotising enterocolitis of human neonates in premature calves with respiratory distress syndrome (RDS).
Ramazan Yildiz, Mahmut Ok, Merve Ider, Aybars Akar, Amir Naseri, Erman Koral   +5 more
doaj   +1 more source

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

Comparison of Tight Junction Protein-Related Gene mRNA Expression Levels between Male and Female Gastroesophageal Reflux Disease Patients

Gut and Liver, 2018
Background/AimsMale predominance has been observed in the erosive reflux disease (ERD), but reverse finding in nonerosive reflux disease (NERD). This suggests sex-specific medicine approach is needed but its mechanism is remained to be elucidated.
Jin Joo Kim, Nayoung Kim, Ji Hyun Park, Young Sun Kim, Sun Min Lee, Dong Ho Lee, Hyun Chae Jung   +6 more
doaj   +1 more source

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis [PDF]

, 2017
Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied.
Alessandro, Riccardo, Ciccia, Francesco, Cypers, Heleen, Di Benedetto, Paola, Elewaut, Dirk, Fasano, Alessio, Gabrielli, Armando, Guggino, Giuliana, Luchetti, Michele Maria, Milling, Simon, Rizzo, Aroldo, Saieva, Laura, Stampone, Tommaso, Triolo, Giovanni   +13 more
core   +2 more sources

Reduction of Ribonucleotide Reductase Subunit RRM2 Potentially Impairs Gut Function of Woody Breast Broilers

Animal Research and One Health, EarlyView.
Woody breast compromises meat quality leading to reduced consumer appeal. Although its causes are unclear, improvements observed with certain dietary supplements suggest that gut health may influence woody breast development. Ribonucleotide reductase subunit RRM2 is vital for mitochondrial function and gastrointestinal integrity, and alteration in its ...
Majid Shakeri, Elizabeth Ziabtchenko, Janghan Choi, Caitlin E. Harris, Richard J. Buhr, Trevor R. Mitchell, Byungwhi Kong, Hong Zhuang, Brian Bowker   +8 more
wiley   +1 more source

TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization

eLife, 2019
Dendritic arbors are crucial for nervous system assembly, but the intracellular mechanisms that govern their assembly remain incompletely understood.
Leo TH Tang, Carlos A Diaz-Balzac, Maisha Rahman, Nelson J Ramirez-Suarez, Yehuda Salzberg, Maria I Lázaro-Peña, Hannes E Bülow   +6 more
doaj   +1 more source

Stresses in silos: Comparison between theoretical models and new experiments

, 1999
We present precise and reproducible mean pressure measurements at the bottom of a cylindrical granular column. If a constant overload is added, the pressure is linear in overload and nonmonotonic in the column height. The results are {\em quantitatively}
A. V. Tkachenko, C. Eloy, C. F. Moukarzel, E. Clément, F. Radjai, H. A. Janssen, J. M. Rotter, J. Munch-Andersen, J. P. Wittmer, J. P. Wittmer, J. P. Wittmer, J. Šmíd, J. Šmíd, J.-P. Bouchaud, J.-P. Bouchaud, J.-Ph. Bouchaud, L. Vanel, L. Vanel, L. Vanel, M. E. Cates, M. E. Cates, M. E. Cates, P. Claudin, P. Claudin, P. Dantu, P. Evesque, P.-G. de Gennes, Ph. Claudin, R. Brockbank, R. L. Brown, R. M. Nedderman, S. F. Edwards, S. F. Edwards, W. H. Press   +33 more
core   +1 more source