Results 101 to 110 of about 56,637 (316)

Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

Pharmaceutics, 2019
The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study
Alexandra Bocsik, Ilona Gróf, Lóránd Kiss, Ferenc Ötvös, Ottó Zsíros, Lejla Daruka, Lívia Fülöp, Monika Vastag, Ágnes Kittel, Norbert Imre, Tamás A. Martinek, Csaba Pál, Piroska Szabó-Révész, Mária A. Deli   +13 more
doaj   +1 more source

Development of Claudin 2 and Claudin 4 in Embryonic and Hatched Chick Intestine

, 2008
The epithelium of the vertebrate intestine is a dynamic structure, under constant renewal. The intestinal crypts represent a proliferative compartment that is monoclonal and is maintained by multiple stem cells.
Wingate, Marvin Jason
core  

Effect of Cyclic Heat Exposure on the Growth Performance and Metabolism of Broilers Fed Palm Kernel Meal

Animal Research and One Health, EarlyView.
The aim of our study is to evaluate the interaction between HS and the incorporation of PKM in broiler chicken diets, as well as its effect on growth performance and metabolism. Based on the results obtained, PKM supplementation failed to mitigate the adverse effects of heat stress in broiler chickens. ABSTRACT The aim of this study was to evaluate the
Ahmed Mijiyawa, Elham Ghashghaei, Okasha Hamada, Huimin Wang, Lijing Sun, Yendouhamtchié Nadiedjoa, Dan Wang, Zhengkai Yue, Clarice Maa Maa Temhoul, Maxwell Ansong Okai, Muhammad Faisal Riaz, Felix Kwame Amevor, Wéré Pitala, Hai Lin   +13 more
wiley   +1 more source

Tight junctional protein family, Claudins in cancer and cancer metastasis

Frontiers in Oncology
Claudin (CLDN) family proteins are key components of tight junctions in epithelial and endothelial cells, crucial for controlling paracellular permeability and cell-cell adhesion.
Wenxiao Ji, Xinguo Zhuang, Xinguo Zhuang, Wen G. Jiang, Tracey A. Martin   +4 more
doaj   +1 more source

Tight junction protein expression from peritoneal dialysis effluent

Renal Failure, 2019
Background: We hypothesized that tight junction (TJ) proteins may have a role in paracellular transport of solute and water in peritoneal dialysis (PD) patients.
Sua Kim, Eun Young Choi, Chor Ho Jo, Gheun-Ho Kim   +3 more
doaj   +1 more source

Claudins in human cancer: a review.

Histology and histopathology, 2009
Claudins are tight junction proteins that are critical for the sealing of cellular sheets and controlling paracellular ion flux. The claudin family of proteins is composed of at least 24 closely related transmembrane proteins, most of them are well characterized at the gene and protein levels.
Ouban, Abderrahman, Ahmed, A.
openaire   +3 more sources

Claudin-1 as a promoter of EMT in hepatocellular carcinoma

, 2013
Claudins are integral structural and functional components of apical cell adhesions (tight junctions). Loss of such adhesions has been associated with malignant transformation, a process most often accompanied by a concomitant loss of claudin expression.
J Stebbing (7628669), Georgios Giamas (4466365), A Filipovic (16220555)   +2 more
core  

Claudin-2 Expression Levels in Ulcerative Colitis: Development and Validation of an In-Situ Hybridisation Assay for Therapeutic Studies.

, 2016
Ulcerative colitis is a chronic inflammatory disease affecting the colon and is characterized by epithelial damage and barrier dysfunction. Upregulation of the tight junction protein claudin-2 by cytokines is hypothesized to contribute to the ...
Glen Hughes, Clare A Balendran, Gerhard Böttcher (483183), Kevin Randall (3106518), Sonia Eckersley (3106509), Kevin Randall, Gerhard Böttcher, Neil Henderson (3106512), Jaimini Reens, Jaimini Reens (3106521), Neil Henderson, Sonia Eckersley, Marie C. South (213182), Clare A. Balendran (3106524), Sally A Price, Ann-Christin Nyström (2532862), Sally A. Price (3106506), Ann-Christin Nyström, Marie C South, Glen Hughes (3106515)   +19 more
core   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile–Young Adult Rats

Microorganisms, 2019
Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the ...
Janyerkye Tulyeu, Hideki Kumagai, Eriko Jimbo, Shinya Watanabe, Koji Yokoyama, Longzhu Cui, Hitoshi Osaka, Makiko Mieno, Takanori Yamagata   +8 more
doaj   +1 more source