Results 101 to 110 of about 79,602 (359)

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Claudin-1 localisation at the tight junctions is disrupted by PAF and restored by BML-111.

, 2023
Composite X/Y confocal images of 16HBE14o- polarised monolayers untreated (control) or treated with P. aeruginosa filtrate (PAF) for 24h or PAF + 200 nmol/L BML-111 (BML) immunostained for (A) ZO-1 (red), (B) Claudin-1 (red), (C) E-cadherin (red). Nuclei
Sonya Jackson (3179151), Deborah L. Baines (11105430), Kameljit K. Kalsi (16496511)   +2 more
core   +1 more source

The Claudin Megatrachea Protein Complex [PDF]

Journal of Biological Chemistry, 2012
Claudins are integral transmembrane components of the tight junctions forming trans-epithelial barriers in many organs, such as the nervous system, lung, and epidermis. In Drosophila three claudins have been identified that are required for forming the tight junctions analogous structure, the septate junctions (SJs).
Jaspers, Martin H. J., Nolde, Kai, Behr, Matthias, Joo, Seol-hee, Plessmann, Uwe, Nikolov, Miroslav, Urlaub, Henning, Schuh, Reinhard   +7 more
openaire   +4 more sources

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

Plasma Levels of Occludin and Claudin-5 in Acute Stroke Are Correlated with the Type and Location of Stroke but Not with the Neurological State of Patients—Preliminary Data

Brain Sciences, 2020
The blood–brain barrier is the structure (BBB), which isolates the central nervous system from the external environmental. During a stroke, the BBB gets damaged, which is accompanied by changes in the concentrations and distributions of claudin-5 ...
Anetta Lasek-Bal, Anna Kokot, Daria Gendosz de Carrillo, Sebastian Student, Katarzyna Pawletko, Aleksandra Krzan, Przemysław Puz, Wiesław Bal, Halina Jędrzejowska-Szypułka   +8 more
doaj   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

HDAC3 regulates the diurnal rhythms of claudin expression and intestinal permeability

Frontiers in Epigenetics and Epigenomics
Circadian rhythms play an essential role in the regulation of intestinal absorption and barrier function. Tight junctions, including claudins, are fundamental components of the intestinal epithelial barrier.
Hunter Christopher, Jianglin Zhang, Sarah Olanrewaju Oladejo, Samskrathi Aravinda Sharma, Zheng Kuang   +4 more
doaj   +1 more source

Claudin-2: Roles beyond Permeability Functions

International Journal of Molecular Sciences, 2019
Claudin-2 is expressed in the tight junctions of leaky epithelia, where it forms cation-selective and water permeable paracellular channels. Its abundance is under fine control by a complex signaling network that affects both its synthesis and turnover ...
Shruthi Venugopal, Shaista Anwer, K. Szászi   +2 more
semanticscholar   +1 more source

Claudin-11 immunohistochemistry in pre- and peripubertal WT and SCCx43KO^-/- mice.

, 2018
(A, C, E, G, I, K) Testes of SCCx43KO-/- mice; (B, D, F, H, J, L) testes of WT mice. Postnatal development in days: Aged 2 (A and B), aged 8 (C and D), aged 12 (E and F), aged 14 (G and H), aged 16 (I and J) and aged 23 (K and L). (A and B) At the age of
Hagen Gasse (745678), Klaus Jung (65489), Ralph Brehm (494774), Julia Hollenbach (4245319), Joanna Noelke (5328341), Christiane Pfarrer (3135114), Mirja Koy (3583109)   +6 more
core   +1 more source