Results 81 to 90 of about 56,637 (316)

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

All about claudins [PDF]

Tissue Barriers, 2013
Since the discovery of Claudins more than a decade ago, much has been learned about their structure-function relationships. Claudins are tetraspan membrane proteins responsible for the formation of tight junctions. In this capacity, Claudins form a tissue-specific selective permeability barrier that is critical for the function of the tissue.
openaire   +2 more sources

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

Plasma Levels of Occludin and Claudin-5 in Acute Stroke Are Correlated with the Type and Location of Stroke but Not with the Neurological State of Patients—Preliminary Data

Brain Sciences, 2020
The blood–brain barrier is the structure (BBB), which isolates the central nervous system from the external environmental. During a stroke, the BBB gets damaged, which is accompanied by changes in the concentrations and distributions of claudin-5 ...
Anetta Lasek-Bal, Anna Kokot, Daria Gendosz de Carrillo, Sebastian Student, Katarzyna Pawletko, Aleksandra Krzan, Przemysław Puz, Wiesław Bal, Halina Jędrzejowska-Szypułka   +8 more
doaj   +1 more source

Discovery, synthesis and biological evaluation of a series of N-(phenylcarbamothioyl)-2-napthamides as inhibitors of Claudin-1

, 2023
Colorectal cancer (CRC) remains a leading cause of cancer-related deaths worldwide, despite advancements in diagnosis. The main reason for this is that many newly diagnosed CRC patients will suffer from metastasis to other organs.
Corey, Hopkins, Thomas, Webster, Anish, Vadukoot, Kirsten, Tolentino, Princess, Simeon, Punita, Dhawan, Viktoriya, Mashinson, Iram, Fatima   +7 more
core   +1 more source

Dielectric Elastomer Actuators as Safe and Effective Tools for Mechanostimulation of Human Cells

Advanced Intelligent Systems, EarlyView.
Replicating physiological forces is crucial for realistic cell models. Dielectric elastomer actuators (DEAs) offer a soft alternative, though their high voltages raised toxicity concerns. We demonstrate that DEA stimulation causes no cell damage, cell death or cell‐cycle disruption, while activating mechanosensitive responses.
Simon Holzer, Chaimae Bahou, Noe Syfrig, Katia Monastyrskaya, Yoan Civet, Ali Hashemi Gheinani, Yves Perriard   +6 more
wiley   +1 more source

HDAC3 regulates the diurnal rhythms of claudin expression and intestinal permeability

Frontiers in Epigenetics and Epigenomics
Circadian rhythms play an essential role in the regulation of intestinal absorption and barrier function. Tight junctions, including claudins, are fundamental components of the intestinal epithelial barrier.
Hunter Christopher, Jianglin Zhang, Sarah Olanrewaju Oladejo, Samskrathi Aravinda Sharma, Zheng Kuang   +4 more
doaj   +1 more source

Claudin-11 immunohistochemistry in pre- and peripubertal WT and SCCx43KO^-/- mice.

, 2018
(A, C, E, G, I, K) Testes of SCCx43KO-/- mice; (B, D, F, H, J, L) testes of WT mice. Postnatal development in days: Aged 2 (A and B), aged 8 (C and D), aged 12 (E and F), aged 14 (G and H), aged 16 (I and J) and aged 23 (K and L). (A and B) At the age of
Hagen Gasse (745678), Klaus Jung (65489), Ralph Brehm (494774), Julia Hollenbach (4245319), Joanna Noelke (5328341), Christiane Pfarrer (3135114), Mirja Koy (3583109)   +6 more
core   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Novel syngeneic model of anti-mouse CLDN18.2 CAR -T therapy for gastric cancer demonstrates a synergy with TGF-β and PD-L1 inhibitors

Molecular Therapy: Oncology
There are very few syngeneic mouse cell line models available for gastric cancer owing to the rarity of stomach epithelium-specific promoter. Mouse cell line models are useful to study an immunologically intact tumor microenvironment, especially in the ...
Min-Jung Seo, Jin Hue Jeong, Han Na Park, In-Pyo Baek, Jun Won Park, Seo Young Kim, Yu Ri Choi, Seulki Choi, Seung Min Ham, Dongmin Park, Hye-Ran Kim, Ho Kyung Seo, Hark Kyun Kim   +12 more
doaj   +1 more source