Results 81 to 90 of about 80,593 (229)
Advanced Science, EarlyView.A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li +6 more
wiley +1 more source
Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas
Cancer Medicine, 2019 Claudin (CLDN) family comprises of protein that form a tight junction, and is involved in regulating polarity and differentiation of cells. Here, we aimed to investigate the effects of inhibiting CLDN4 in pancreatic ductal carcinomas (PDC).
Takamitsu Sasaki +12 more
doaj +1 more source
Reconstitution of functional tight junctions with individual claudin subtypes in epithelial cells
Cell Structure and Function, 2022 The claudin family of membrane proteins is responsible for the backbone structure and function of tight junctions (TJs), which regulate the paracellular permeability of epithelia.
Mikio Furuse +8 more
doaj +1 more source
Rheology of dense granular flows for elongated particles [PDF]
, 2017 We study the rheology of dense granular flows for frictionless spherocylinders by means of 3D numerical simulations. As in the case of spherical particles, the effective friction $\mu$ is an increasing function of the inertial number $I$, and we ...
Börzsönyi, Tamás +3 more
core +1 more source
Tissue Barriers, 2013 Since the discovery of Claudins more than a decade ago, much has been learned about their structure-function relationships. Claudins are tetraspan membrane proteins responsible for the formation of tight junctions. In this capacity, Claudins form a tissue-specific selective permeability barrier that is critical for the function of the tissue.
openaire +2 more sources
Advanced Science, EarlyView.Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen +6 more
wiley +1 more source
Comment on "Minimal size of a barchan dune"
, 2007 It is now an accepted fact that the size at which dunes form from a flat sand bed as well as their `minimal size' scales on the flux saturation length.
B. Andreotti, J. E. Ungar, P. Claudin
core +3 more sources
Hepatoma cell density promotes claudin-1 and scavenger receptor BI expression and hepatitis C virus internalization. [PDF]
, 2009 Hepatitis C virus (HCV) entry occurs via a pH- and clathrin-dependent endocytic pathway and requires a number of cellular factors, including CD81, the tight-junction proteins claudin 1 (CLDN1) and occludin, and scavenger receptor class B member I (SR-BI).
Balfe, Peter +5 more
core +2 more sources
Advanced Science, EarlyView.Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk +9 more
wiley +1 more source
Footprints in Sand: The Response of a Granular Material to Local Perturbations
, 2001 We experimentally determine ensemble-averaged responses of granular packings to point forces, and we compare these results to recent models for force propagation in a granular material.
B. J. Miller +29 more
core +1 more source