Results 111 to 120 of about 80,593 (229)

Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. [PDF]

, 2020
Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in ...
Bangash, Maria, Cribbs, David H, Fisher, Mark, Floriolli, David, Lau, Wei Ling, Lertpanit, Long, Naqvi, Sameen, Nunes, Ane CF, Paganini-Hill, Annlia, Savoj, Javad, Shah, Krunal, Vasilevko, Vitaly, Vaziri, Nosratola D, Yao, Zhihui   +13 more
core  

Claudins and hepatocellular carcinoma

Biomedicine & Pharmacotherapy
Hepatocellular carcinoma (HCC) has a high incidence and dismal prognosis, making it a significant global health burden. To change this, the development of new therapeutic strategies is imminent. The claudin (CLDN) family, as key components of tight junctions (TJs), plays an important role in the initiation and development of cancer.
Wentao Wang, Yi Zhou, Wei Li, Chengshi Quan, Yanru Li   +4 more
openaire   +2 more sources

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

Pharmaceutics, 2019
The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study
Alexandra Bocsik, Ilona Gróf, Lóránd Kiss, Ferenc Ötvös, Ottó Zsíros, Lejla Daruka, Lívia Fülöp, Monika Vastag, Ágnes Kittel, Norbert Imre, Tamás A. Martinek, Csaba Pál, Piroska Szabó-Révész, Mária A. Deli   +13 more
doaj   +1 more source

Tight junctional protein family, Claudins in cancer and cancer metastasis

Frontiers in Oncology
Claudin (CLDN) family proteins are key components of tight junctions in epithelial and endothelial cells, crucial for controlling paracellular permeability and cell-cell adhesion.
Wenxiao Ji, Xinguo Zhuang, Xinguo Zhuang, Wen G. Jiang, Tracey A. Martin   +4 more
doaj   +1 more source

Tight junction protein expression from peritoneal dialysis effluent

Renal Failure, 2019
Background: We hypothesized that tight junction (TJ) proteins may have a role in paracellular transport of solute and water in peritoneal dialysis (PD) patients.
Sua Kim, Eun Young Choi, Chor Ho Jo, Gheun-Ho Kim   +3 more
doaj   +1 more source

Claudins [PDF]

Current Biology, 2004
Peter, Yakov, Goodenough, Daniel
openaire   +2 more sources

Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile–Young Adult Rats

Microorganisms, 2019
Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the ...
Janyerkye Tulyeu, Hideki Kumagai, Eriko Jimbo, Shinya Watanabe, Koji Yokoyama, Longzhu Cui, Hitoshi Osaka, Makiko Mieno, Takanori Yamagata   +8 more
doaj   +1 more source

Sensitivity of the stress response function to packing preparation

, 2005
A granular assembly composed of a collection of identical grains may pack under different microscopic configurations with microscopic features that are sensitive to the preparation history.
, A P F Atman, Allen M P, Atman A P F, Behringer R P, Cates M E, Christoffersen J, da Silveira R Vidalenc G Gay C, E Clément, G Combe, G Reydellet, Gland N Wang P Makse H A, Goldenberg C, Goldenberg C, Head D A, Herrmann H J, J Geng, Kasahara A Nakanishi H, Liu C-h, Moreau J-J, Moukarzel C F, Ostojic S Panja D, Ostojic S Panja D, P Brunet, P Claudin, R P Behringer, Radjai F, Rothenburg L Selvadurai A P S, Roux J-N, Savage S, Schneebeli G, Serero D, Spannuth M J Mueggenburg N W Jaeger H M Nagel S R, Šmíd J   +33 more
core   +2 more sources

Claudins in human cancer: a review.

Histology and histopathology, 2009
Claudins are tight junction proteins that are critical for the sealing of cellular sheets and controlling paracellular ion flux. The claudin family of proteins is composed of at least 24 closely related transmembrane proteins, most of them are well characterized at the gene and protein levels.
Ouban, Abderrahman, Ahmed, A.
openaire   +3 more sources