Results 131 to 140 of about 79,602 (359)
Tight junction protein expression from peritoneal dialysis effluent
Background: We hypothesized that tight junction (TJ) proteins may have a role in paracellular transport of solute and water in peritoneal dialysis (PD) patients.
Sua Kim +3 more
doaj +1 more source
Analysis of Xenopus laevis claudin (Xcla) Tight Junction Genes in Development
Eight Xenopus laevis claudin genes, Xcla1, Xcla4B, Xcla5, Xcla6, Xcla12, Xcla16, Xcla18 and Xcla19, were cloned and sequenced. Their normal mRNA expression was determined from cleavage stage to tadpole stage by whole mount in situ hybridization.
Xie, Jianzhen
core
Mode of action of claudin peptidomimetics in the transient opening of cellular tight junction barriers [PDF]
In epithelial/endothelial barriers, claudins form tight junctions, seal the paracellular cleft, and limit the uptake of solutes and drugs. The peptidomimetic C1C2 from the C-terminal half of claudin-1's first extracellular loop increases drug delivery ...
Staat, Christian +7 more
core +1 more source
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang +12 more
wiley +1 more source
Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the ...
Janyerkye Tulyeu +8 more
doaj +1 more source
[Vente. Livres. 1887-03-30 - 1887-04-02. Paris][Collection. Livres. G***, A.. 1887]Référence bibliographique : Lugt, 46419Appartient à l’ensemble documentaire : VenteEST2Contient une table des matièresAvec mode ...
core
Claudin-5 subcellular localization along the oxygen-glucose deprivation (OGD) and medium exchange.
Figs A-C show antibody staining of Claudin-5 under the different treatments. Bars = 10 μm. N = 1; n = 3. (D) For each condition, the intracellular signal intensity was estimated using ImageJ as described in the “Materials and methods” section. Bar graphs
Erica Tornabene (7274117) +3 more
core +1 more source
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li +20 more
wiley +1 more source
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
The tight junction (TJ) and its adhesion molecules, claudins, are responsible for the barrier function of simple epithelia, but TJs have not been thought to play an important role in the barrier function of mammalian stratified epithelia, including the ...
M. Furuse +8 more
semanticscholar +1 more source

