Results 121 to 130 of about 80,593 (229)

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation [PDF]

, 2016
Plasticity in epithelial tissues relates to processes of embryonic development, tissue fibrosis and cancer progression. Pharmacological modulation of epithelial transitions during disease progression may thus be clinically useful.
Bellomo, C, Bickle, M, Carthy, JM, Gahman, TC, Heldin, A, Heldin, CH, Kardassis, D, Morén, A, Moustakas, A, Shiau, AK, Stöter, M, Vanlandewijck, M, Zerial, M   +12 more
core   +1 more source

Evidence to Date on the Therapeutic Potential of Zolbetuximab in Advanced Gastroesophageal Adenocarcinoma

Current Oncology
Gastric adenocarcinoma (GAC) continues to be a prevalent worldwide malignancy and a leading cause of cancer death, and it is frequently cited as incurable. Targeted therapy in GAC has lagged behind other solid tumors.
Jane E. Rogers, Jaffer Ajani
doaj   +1 more source

Celiac Disease Monocytes Induce a Barrier Defect in Intestinal Epithelial Cells [PDF]

, 2019
Intestinal epithelial barrier function in celiac disease (CeD) patients is altered. However, the mechanism underlying this effect is not fully understood.
Branchi, Federica, Cardoso-Silva, Danielle, Delbue, Deborah, Itzlinger, Alice, Letizia, Marilena, Schumann, Michael, Siegmund, Britta   +6 more
core   +1 more source

Jamming and Stress Propagation in Particulate Matter

, 1998
We present simple models of particulate materials whose mechanical integrity arises from a jamming process. We argue that such media are generically "fragile", that is, they are unable to support certain types of incremental loading without plastic ...
Alexander, Bak, Ball, Bouchaud, Bouchaud, Brockbank, Cates, Claudin, Claudin, Cundall, Dantu, Edwards, Edwards, Edwards, Edwards, Farr, Gudehus, Hooke, J.-P. Bouchaud, J.P. Wittmer, Kolymbas, Laun, Liu, M.E. Gates, Melrose, Nagel, P. Claudin, Radjai, Smid, Thornton, Thornton, Wittmer, Wittmer, Wood   +33 more
core   +2 more sources

A model for ripple instabilities in granular media

, 1998
We extend the model of surface granular flow proposed in \cite{bcre} to account for the effect of an external `wind', which acts as to dislodge particles from the static bed, such that a stationary state of flowing grains is reached. We discuss in detail
Bouchaud, Jean-Philippe, Claudin, Philippe, Terzidis, Orestis   +2 more
core   +1 more source

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source

Robust propagation direction of stresses in a minimal granular packing

, 2001
By employing the adaptive network simulation method, we demonstrate that the ensemble-averaged stress caused by a local force for packings of frictionless rigid beads is concentrated along rays whose slope is consistent with unity: forces propagate along
Head, D. A., Tkachenko, A. V., Witten, T. A.   +2 more
core   +1 more source

Cracking Piles of Brittle Grains

, 1998
A model which accounts for cracking avalanches in piles of grains subject to external load is introduced and numerically simulated. The stress is stochastically transferred from higher layers to lower ones.
C. C. Mounfield, C. Poirier, C.-H. Liu, D. Bideau, F. Radjai, František Slanina, G. A. Held, H. A. Makse, H. M. Jaeger, H.-M. Bröker, J. P. Wittmer, J. Šmíd, J.-P. Bouchaud, M. Marsili, M. Paczuski, P. Claudin, P. Claudin, P. Claudin, P. Evesque, P. Grassberger, Per Bak, S. F. Edwards, S. F. Edwards, S. N. Coppersmith, S. N. Coppersmith, S. Ouaguenouni, S. R. Nagel, S. Redner, S. Zapperi, T. Le Pennec, Z. Olami   +30 more
core   +1 more source

Interrogações sobre a Revolução de Outubro

Lua Nova: Revista de Cultura e Política, 1990
Fernando Claudín
doaj   +1 more source

Assessment of equine intestinal epithelial junctional complexes and barrier permeability using a monolayer culture system

Frontiers in Veterinary Science
Gastrointestinal disease is a leading cause of death in mature horses. A lack of in vitro modeling has impeded the development of novel therapeutics. The objectives of this study were to develop and further characterize a small intestinal monolayer cell ...
Amy Stieler Stewart, Jamie J. Kopper, Caroline McKinney-Aguirre, Brittany Veerasamy, Dipak Kumar Sahoo, John M. Freund, Liara M. Gonzalez   +6 more
doaj   +1 more source