Results 121 to 130 of about 79,602 (359)

Hollow Cu2O Nanozymes Enhance Probiotic Therapy for Colitis via Redox Homeostasis and TXNIP/NLRP3 Inflammasome Inhibition

Advanced Science, EarlyView.
Hollow cuprous oxide (H‐Cu2O) nanozymes feature enlarged catalytic surfaces for superior reactive oxygen species (ROS) scavenging. By efficiently neutralizing mucosal ROS, H‐Cu2O directly suppresses the TXNIP/NLRP3 inflammasome axis and restores intestinal epithelial barrier integrity.
Guangzhao Wang, Jialing Cao, Pengfei Li, Yujie Wang, Shiqi Lu, Kangliang Sheng, Shan Gao, Yongzhong Wang   +7 more
wiley   +1 more source

TIAM-1/GEF can shape somatosensory dendrites independently of its GEF activity by regulating F-actin localization

eLife, 2019
Dendritic arbors are crucial for nervous system assembly, but the intracellular mechanisms that govern their assembly remain incompletely understood.
Leo TH Tang, Carlos A Diaz-Balzac, Maisha Rahman, Nelson J Ramirez-Suarez, Yehuda Salzberg, Maria I Lázaro-Peña, Hannes E Bülow   +6 more
doaj   +1 more source

IL-22 upregulates epithelial claudin-2 to drive diarrhea and enteric pathogen clearance

Cell Host and Microbe, 2017
SUMMARY Diarrhea is a host response to enteric pathogens, but its impact on pathogenesis remains poorly defined. By infecting mice with the attaching and effacing bacteria Citrobacter rodentium, we defined the mechanisms and contributions of diarrhea and
Pei-Yun Tsai, Bing-Kun Zhang, Wei-Qi He, Juan-Min Zha, M. Odenwald, Gurminder Singh, Atsushi Tamura, Le Shen, A. Sailer, Sunil Yeruva, Wei-Ting Kuo, Yang-Xin Fu, S. Tsukita, J. Turner   +13 more
semanticscholar   +1 more source

Development of Claudin 2 and Claudin 4 in Embryonic and Hatched Chick Intestine

, 2008
The epithelium of the vertebrate intestine is a dynamic structure, under constant renewal. The intestinal crypts represent a proliferative compartment that is monoclonal and is maintained by multiple stem cells.
Wingate, Marvin Jason
core  

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

Dual Action of the PN159/KLAL/MAP Peptide: Increase of Drug Penetration across Caco-2 Intestinal Barrier Model by Modulation of Tight Junctions and Plasma Membrane Permeability

Pharmaceutics, 2019
The absorption of drugs is limited by the epithelial barriers of the gastrointestinal tract. One of the strategies to improve drug delivery is the modulation of barrier function by the targeted opening of epithelial tight junctions. In our previous study
Alexandra Bocsik, Ilona Gróf, Lóránd Kiss, Ferenc Ötvös, Ottó Zsíros, Lejla Daruka, Lívia Fülöp, Monika Vastag, Ágnes Kittel, Norbert Imre, Tamás A. Martinek, Csaba Pál, Piroska Szabó-Révész, Mária A. Deli   +13 more
doaj   +1 more source

Claudin-12 Knockout Mice Demonstrate Reduced Proximal Tubule Calcium Permeability

International Journal of Molecular Sciences, 2020
The renal proximal tubule (PT) is responsible for the reabsorption of approximately 65% of filtered calcium, primarily via a paracellular pathway. However, which protein(s) contribute this paracellular calcium pore is not known.
Allein Plain, Wanling Pan, D. O'Neill, Megan Ure, Megan R Beggs, Maikel A. Farhan, H. Dimke, Emmanuelle Cordat, R. T. Alexander   +8 more
semanticscholar   +1 more source

Claudin-1 as a promoter of EMT in hepatocellular carcinoma

, 2013
Claudins are integral structural and functional components of apical cell adhesions (tight junctions). Loss of such adhesions has been associated with malignant transformation, a process most often accompanied by a concomitant loss of claudin expression.
J Stebbing (7628669), Georgios Giamas (4466365), A Filipovic (16220555)   +2 more
core  

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Tight junctional protein family, Claudins in cancer and cancer metastasis

Frontiers in Oncology
Claudin (CLDN) family proteins are key components of tight junctions in epithelial and endothelial cells, crucial for controlling paracellular permeability and cell-cell adhesion.
Wenxiao Ji, Xinguo Zhuang, Xinguo Zhuang, Wen G. Jiang, Tracey A. Martin   +4 more
doaj   +1 more source