Results 41 to 50 of about 14,885 (290)
Antibody-mediated targeting of Claudins in cancer
Frontiers in OncologyTight junctions (TJs) are large intercellular adhesion complexes that maintain cell polarity in normal epithelia and endothelia. Claudins are critical components of TJs, forming homo- and heteromeric interaction between adjacent cells, which have emerged
Benjamin Vonniessen +8 more
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Barriers built on claudins [PDF]
Journal of Cell Science, 2004 The fundamental functions of epithelia and endothelia in multicellular organisms are to separate compositionally distinct compartments and regulate the exchange of small solutes and other substances between them. Tight junctions (TJs) between adjacent cells constitute the barrier to the passage of ions and molecules through the paracellular pathway and
Kursad, Turksen, Tammy-Claire, Troy
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Antioxidants, 2022 The present study was a part of a larger research project that aimed to investigate the effects of Met-Met supplementation on fish growth and intestinal health. This study mainly focused on the relationship between dietary Met-Met and intestinal physical
Pei Wu +8 more
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Frontiers in Physiology, 2017 The pig represents a preferred model for the analysis of intestinal immunology. However, the barrier of the follicle-associated epithelium (FAE) covering porcine Peyer's patches (PP) has not yet been characterized in detail.
Judith Radloff +3 more
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Frontiers in Physiology, 2020 Claudin-5 determines the sealing properties of blood-brain barrier tight junctions and its function is impaired in neurodegenerative and neuroinflammatory disorders.
Nora Brunner +5 more
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Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Claudin (CLDN) proteins, a tetra-transmembrane family containing over 20 members, have been identified as key structural and functional components of intercellular seals, tight junctions (TJs). CLDNs are involved in the barrier and fence functions of TJs. Loosening the TJ barrier is one strategy for increasing drug absorption and delivery to the brain.
Yosuke, Hashimoto +7 more
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Emerging Roles of Claudins in Human Cancer
, 2013 Claudins are major integral membrane proteins of tight junctions. Altered expression of several claudin proteins, in particular claudin-1, -3, -4 and -7, has been linked to the development of various cancers.
Mi Kwon
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Claudins and mineral metabolism [PDF]
Current Opinion in Nephrology and Hypertension, 2016 The tight junction conductance made of the claudin-based paracellular channel is important in the regulation of calcium and magnesium reabsorption in the kidney. This review describes recent findings of the structure, the function, and the physiologic regulation of claudin-14, claudin-16, and claudin-19 channels that through protein interactions confer
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Occludin is required for apoptosis when claudin–claudin interactions are disrupted [PDF]
Cell Death & Disease, 2012 Disruption of tight junctions is often seen during pathogen infection, inflammation, and tumor progression. Mislocalization of the tight junction proteins occludin and claudin in mammary epithelial monolayers leads to apoptosis through the extrinsic pathway.
Beeman, N, Webb, P G, Baumgartner, H K
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miR-195-5p Regulates Tight Junctions Expression via Claudin-2 Downregulation in Ulcerative Colitis
Biomedicines, 2022 Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation associated with an increased intestinal permeability. Several studies have shown that microRNAs (miRNAs) are involved in the IBD pathogenesis.
Viviana Scalavino +6 more
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