Results 41 to 50 of about 14,180 (293)
Occludin is required for apoptosis when claudin–claudin interactions are disrupted [PDF]
Cell Death & Disease, 2012 Disruption of tight junctions is often seen during pathogen infection, inflammation, and tumor progression. Mislocalization of the tight junction proteins occludin and claudin in mammary epithelial monolayers leads to apoptosis through the extrinsic pathway.
Beeman, N, Webb, P G, Baumgartner, H K
openaire +2 more sources
Emerging Roles of Claudins in Human Cancer
, 2013 Claudins are major integral membrane proteins of tight junctions. Altered expression of several claudin proteins, in particular claudin-1, -3, -4 and -7, has been linked to the development of various cancers.
Mi Kwon
core +1 more source
Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2019 Claudin (CLDN) proteins, a tetra-transmembrane family containing over 20 members, have been identified as key structural and functional components of intercellular seals, tight junctions (TJs). CLDNs are involved in the barrier and fence functions of TJs. Loosening the TJ barrier is one strategy for increasing drug absorption and delivery to the brain.
Yosuke, Hashimoto +7 more
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Frontiers in Physiology, 2017 The pig represents a preferred model for the analysis of intestinal immunology. However, the barrier of the follicle-associated epithelium (FAE) covering porcine Peyer's patches (PP) has not yet been characterized in detail.
Judith Radloff +3 more
doaj +1 more source
Frontiers in Physiology, 2020 Claudin-5 determines the sealing properties of blood-brain barrier tight junctions and its function is impaired in neurodegenerative and neuroinflammatory disorders.
Nora Brunner +5 more
doaj +1 more source
Claudin-16 and claudin-19 function in the thick ascending limb [PDF]
Current Opinion in Nephrology and Hypertension, 2010 Claudin-16 and claudin-19 play a major role in the regulation of magnesium reabsorption in the thick ascending limb (TAL). This review describes recent findings of the physiological function of claudin-16 and claudin-19 underlying normal transport function for magnesium reabsorption in the TAL.Mutations in the genes encoding the tight junction proteins
Jianghui, Hou, Daniel A, Goodenough
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Physiological Reports, 2022 The plant alkaloid berberine has been shown to have many beneficial effects on human health. This has led to its use as a treatment for various cancer types, obesity, and diabetes.
Valeria Cornelius +3 more
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Frontiers in Cellular and Infection Microbiology, 2022 Aeromonas sobria is a Gram-negative pathogen that causes food-borne illness. In immunocompromised patients and the elderly, A. sobria opportunistically leads to severe extraintestinal diseases including sepsis, peritonitis, and meningitis. If A.
Mitsunobu Ueda +5 more
doaj +1 more source
Claudins and Regulation of the Paracellular Transport System
, 2006 Epithelia create barriers and regulate solute and water transport through transcellular and paracellular pathways. The paracellular pathways of different tissues vary remarkably in size selectivity, ionic charge selectivity and transepithelial electrical
Rasmussen, Julia E.
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Advanced Healthcare Materials, EarlyView.This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino +12 more
wiley +1 more source