Role of Stress on Driving the Intestinal Paracellular Permeability [PDF]
Current Issues in Molecular Biology, 2023 The gut epithelium is a polarized monolayer that exhibits apical and basolateral membrane surfaces. Monolayer cell components are joined side by side via protein complexes known as tight junction proteins (TJPs), expressed at the most apical extreme of ...
Maria Elisa Drago-Serrano +2 more
exaly +6 more sources
Effect of Lactobacilli on Paracellular Permeability in the Gut [PDF]
Nutrients, 2011 Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the ...
Ahrne, Siv +1 more
exaly +5 more sources
Colonic paracellular permeability and circulating zonulin-related proteins [PDF]
Scandinavian Journal of Gastroenterology, 2021 Irritable bowel syndrome (IBS) is a gut-brain disorder associated with increased gut permeability. Zonulin has been suggested to regulate the gut barrier and claimed to be pre-haptoglobin 2 (pre-HP2) and circulating zonulin is often used as a proxy for gastrointestinal permeability.
Johan Dabrosin Söderholm +2 more
exaly +4 more sources
Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis [PDF]
eLife, 2019 The blood-brain barrier (BBB) is formed by the endothelial cells lining cerebral microvessels, but how blood-borne signaling molecules influence permeability is incompletely understood. We here examined how the apolipoprotein M (apoM)-bound sphingosine 1–
Mette Mathiesen Janiurek +4 more
doaj +5 more sources
High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway [PDF]
Cells, 2021 Tight junctions (TJs) play an important role in water, ion, and solute transport through the paracellular pathway of epithelial cells; however, their role in diabetes-induced salivary gland dysfunction remains unknown. Here, we found that the TJ proteins
Yan Huang +9 more
doaj +2 more sources
Paracellular permeability and tight junction regulation in gut health and disease. [PDF]
Nat Rev Gastroenterol Hepatol, 2023 Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight junctions via two distinct size-selective and charge-selective paracellular pathways: the pore pathway and the leak pathway. These can be distinguished by their selectivities and differential regulation by immune cells.
Horowitz A +3 more
europepmc +3 more sources
Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis [PDF]
VirusesSARS-CoV-2 primarily infects the lungs via the ACE2 receptor but also other organs including the kidneys, the gastrointestinal tract, the heart, and the skin.
Taylor E. Martinez +3 more
doaj +2 more sources
Sound conditioning strategy promoting paracellular permeability of the blood‐labyrinth‐barrier benefits inner ear drug delivery [PDF]
Bioengineering & Translational MedicineThe therapeutic effects of pharmaceuticals depend on their drug concentrations in the cochlea. Efficient drug delivery from the systemic circulation into the inner ear is limited by the blood‐labyrinth‐barrier (BLB).
Xueling Wang +5 more
doaj +2 more sources
Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions [PDF]
FASEB BioAdvancesIntestinal paracellular permeability was analyzed ex vivo by incubation of tissue segments at 0°C with the fluorescent dyes FM1‐43FX (FM) or TRITC‐dextran 3 kDa lysine‐fixable (TD3L) and confocal microscopy in (i) healthy mice and (ii) mice submitted to ...
Mathilde Miquel +10 more
doaj +2 more sources
Mapping the Blood Vessels with Paracellular Permeability in the Retinas of Diabetic Rats
Investigative Opthalmology & Visual Science, 2003 Diabetic retinopathy increases the permeability of the blood-retinal barrier, but the specific vessels that become permeable have not been identified. Both transcellular and paracellular pathways of vascular solute flux have been proposed. This study was conducted to test the hypothesis that paracellular flux contributes to increased retinal vascular ...
David Antonetti, Alistair Barber
exaly +3 more sources