Role of Stress on Driving the Intestinal Paracellular Permeability [PDF]
Current Issues in Molecular Biology, 2023 The gut epithelium is a polarized monolayer that exhibits apical and basolateral membrane surfaces. Monolayer cell components are joined side by side via protein complexes known as tight junction proteins (TJPs), expressed at the most apical extreme of ...
Daniel Efrain Molotla-Torres +3 more
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Paracellular permeability and tight junction regulation in gut health and disease [PDF]
Nature Reviews Gastroenterology and Hepatology, 2023 Epithelial tight junctions define the paracellular permeability of the intestinal barrier. Molecules can cross the tight junctions via two distinct size-selective and charge-selective paracellular pathways: the pore pathway and the leak pathway. These can be distinguished by their selectivities and differential regulation by immune cells.
Arie Horowitz +2 more
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High Glucose Reduces the Paracellular Permeability of the Submandibular Gland Epithelium via the MiR-22-3p/Sp1/Claudin Pathway [PDF]
Cells, 2021 Tight junctions (TJs) play an important role in water, ion, and solute transport through the paracellular pathway of epithelial cells; however, their role in diabetes-induced salivary gland dysfunction remains unknown. Here, we found that the TJ proteins
Yan Huang +9 more
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Apolipoprotein M-bound sphingosine-1-phosphate regulates blood–brain barrier paracellular permeability and transcytosis [PDF]
eLife, 2019 The blood-brain barrier (BBB) is formed by the endothelial cells lining cerebral microvessels, but how blood-borne signaling molecules influence permeability is incompletely understood. We here examined how the apolipoprotein M (apoM)-bound sphingosine 1–
Mette Mathiesen Janiurek +4 more
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Modulation of Paracellular Permeability in SARS-CoV-2 Blood-to-Brain Transcytosis [PDF]
VirusesSARS-CoV-2 primarily infects the lungs via the ACE2 receptor but also other organs including the kidneys, the gastrointestinal tract, the heart, and the skin.
Taylor E. Martinez +3 more
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Sound conditioning strategy promoting paracellular permeability of the blood‐labyrinth‐barrier benefits inner ear drug delivery [PDF]
Bioengineering & Translational MedicineThe therapeutic effects of pharmaceuticals depend on their drug concentrations in the cochlea. Efficient drug delivery from the systemic circulation into the inner ear is limited by the blood‐labyrinth‐barrier (BLB).
Xueling Wang +5 more
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Mapping Intestinal Paracellular Perm Eability in Mice: Regional and Cellular Variability Under Physiological and Stimulated Conditions [PDF]
FASEB BioAdvancesIntestinal paracellular permeability was analyzed ex vivo by incubation of tissue segments at 0°C with the fluorescent dyes FM1‐43FX (FM) or TRITC‐dextran 3 kDa lysine‐fixable (TD3L) and confocal microscopy in (i) healthy mice and (ii) mice submitted to ...
Mathilde Miquel +10 more
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GLP-2 Acutely Prevents Endotoxin-Related Increased Intestinal Paracellular Permeability in Rats [PDF]
Digestive Diseases and Sciences, 2020 Yasutada Akiba +2 more
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Acta Pharmaceutica Sinica B, 2021 Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat, a 349 Da peptide, but not hexarelin (887 Da). The primary aim of this paper was to investigate if paracellular permeability enhancers affected the ...
David Dahlgren +4 more
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Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis [PDF]
Fluids and Barriers of the CNSBackground The blood-brain barrier (BBB) paracellular permeability must be evaluated in various contexts in vitro and in vivo, including pharmacological evaluation of drug candidates, investigations of pathological changes in disease and model ...
Cindy Bay +7 more
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