Differential effects of TNF (TNFSF2) and IFN-γ on intestinal epithelial cell morphogenesis and barrier function in three-dimensional culture. [PDF]
PLoS ONE, 2011 BackgroundThe cytokines TNF (TNFSF2) and IFNγ are important mediators of inflammatory bowel diseases and contribute to enhanced intestinal epithelial permeability by stimulating apoptosis and/or disrupting tight junctions.
Kati Juuti-Uusitalo +7 more
doaj +1 more source
Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. [PDF]
PLoS Genetics, 2017 Claudins constitute the major component of tight junctions and regulate paracellular permeability of epithelia. Claudin-10 occurs in two major isoforms that form paracellular channels with ion selectivity.
Joakim Klar +14 more
doaj +1 more source
An on-chip model of protein paracellular and transcellular permeability in the microcirculation [PDF]
Biomaterials, 2019 Recent therapeutic success of large-molecule biologics has led to intense interest in assays to measure with precision their transport across the vascular endothelium and into the target tissue. Most current in vitro endothelial models show unrealistically large permeability coefficients due to a non-physiological paracellular transport.
Offeddu, Giovanni +7 more
openaire +4 more sources
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression [PDF]
, 2009 The gastrointestinal tract represents the first barrier against food contaminants as well as the first target for these toxicants. Deoxynivalenol (DON) is a mycotoxin that commonly contaminates cereals and causes various toxicological effects.
Bracarense, Ana-Paula +8 more
core +2 more sources
Effect of permeability enhancers on paracellular permeability of acyclovir
Journal of Pharmacy and Pharmacology, 2016 AbstractObjectivesAccording to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir ...
Ates, Muge +2 more
openaire +3 more sources
Role of claudins in renal calcium handling
Nefrología (English Edition), 2015 Paracellular channels occurring in tight junctions play a major role in transepithelial ionic flows. This pathway includes a high number of proteins, such as claudins.
Armando Luis Negri
doaj +1 more source
Claudins in the Renal Collecting Duct [PDF]
, 2019 The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis.
Leiz, Janna, Schmitt-Ott, Kai M.
core +1 more source
Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration. [PDF]
PLoS ONE, 2008 Local edema, a cardinal sign of inflammation associates closely with neutrophil emigration. Neutrophil emigration has been described to occur primarily through endothelial junctions (paracellular) and more rarely directly through endothelial cells ...
Mia Phillipson +4 more
doaj +1 more source
Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity [PDF]
, 2017 An increased permeability of the intestinal barrier is proposed as a major event in the pathophysiology of conditions characterized by chronic gut inflammation.
Anderson, Maureen +8 more
core +1 more source
Scientific Reports, 2023 The large intestine plays a pivotal role in water and electrolyte balance. Paracellular transport may play a role in ion transport mechanisms in the cecum and large intestine; however, these molecular mechanisms and their physiological roles have not ...
Wendy Hempstock +3 more
doaj +1 more source