Effect of permeability enhancers on paracellular permeability of acyclovir
Journal of Pharmacy and Pharmacology, 2016 AbstractObjectivesAccording to Biopharmaceutics Classification System (BCS), acyclovir is a class III (high solubility, low permeability) compound, and it is transported through paracellular route by passive diffusion. The aim of this study was to investigate the effect of various pharmaceutical excipients on the intestinal permeability of acyclovir ...
Ates, Muge +2 more
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Acta Pharmaceutica Sinica B, 2021 Transcellular permeation enhancers are known to increase the intestinal permeability of enalaprilat, a 349 Da peptide, but not hexarelin (887 Da). The primary aim of this paper was to investigate if paracellular permeability enhancers affected the ...
David Dahlgren +4 more
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Nitric oxide enhances paracellular permeability of opossum kidney cells [PDF]
Kidney International, 1999 Nitric oxide (NO) has been shown to be a paracrine/autocrine regulator of proximal tubular transport. In this study, we investigated the effect of NO on the paracellular permeability of opossum kidney (OK) cells, a proximal tubule cell line that possesses a leaky paracellular pathway resembling that of the in vivo proximal tubule.Paracellular ...
Liang, Mingyu, Knox, Franklyn G.
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Altered paracellular cation permeability due to a rare CLDN10B variant causes anhidrosis and kidney damage. [PDF]
PLoS Genetics, 2017 Claudins constitute the major component of tight junctions and regulate paracellular permeability of epithelia. Claudin-10 occurs in two major isoforms that form paracellular channels with ion selectivity.
Joakim Klar +14 more
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Endothelial domes encapsulate adherent neutrophils and minimize increases in vascular permeability in paracellular and transcellular emigration. [PDF]
PLoS ONE, 2008 Local edema, a cardinal sign of inflammation associates closely with neutrophil emigration. Neutrophil emigration has been described to occur primarily through endothelial junctions (paracellular) and more rarely directly through endothelial cells ...
Mia Phillipson +4 more
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The Effect of Hyperosmosis on Paracellular Permeability in Caco-2 Cell Monolayers
Bioscience, Biotechnology and Biochemistry, 2009 The intestinal epithelium is a significant barrier to oral absorption of hydrophilic compounds, and their passage through the intercellular space is restricted by the tight junctions. In this study we found that hyperosmosis is a significant factor altering paracellular transport in Caco-2 cell monolayers.
INOKUCHI, Hitoshi +3 more
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Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice [PDF]
Frontiers in Immunology, 2021 Véronique Douard +2 more
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Baicalin-Induced Autophagy Preserved LPS-Stimulated Intestinal Cells from Inflammation and Alterations of Paracellular Permeability [PDF]
International Journal of Molecular Sciences, 2021 Daniela Caccamo +2 more
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Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis [PDF]
Fluids and Barriers of the CNSBackground The blood-brain barrier (BBB) paracellular permeability must be evaluated in various contexts in vitro and in vivo, including pharmacological evaluation of drug candidates, investigations of pathological changes in disease and model ...
Cindy Bay +7 more
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Pharmaceutics, 2022 The purpose of this study was to evaluate mechanisms behind the intestinal permeability of minoxidil, with special emphasis on paracellular transport, and elucidate the suitability of minoxidil to be a reference drug for Biopharmaceutics Classification ...
Milica Markovic +6 more
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